{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T15:39:14Z","timestamp":1787585954681,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>The purpose of the current article was to evaluate the recently published researches on the use of lycopene and curcumin in oral leukoplakia (OL) and oral submucous fibrosis (OSF). A comprehensive review of the current researches enveloping PubMed, Ovid, and Cochrane was made using the keywords [(Lycopene) OR (Curcumin) AND (Leukoplakia OR OL OR OSF OR OSMF OR OSF OR Submucous Fibrosis)]. We included only randomized control trials and in the English language. The search covers the data from 1994 to August 2020. Six studies (2 of OL and 4 of OSF) finally qualified are included in the study for the qualitative analysis of the result. Out of these six studies, four were found having high risk, one with unclear risk and one with low risk. Only one study came out as finally suitable for the quantitative analysis of the result. A total of 90 participants were included in this review, with a mean age of 32 with a range of 17\u201360 years. Out of 90 participants, 70 were male and 20 were female. It is evident from the result of this study that the use of oral curcumin and lycopene has significant improvement in the mouth opening, burning sensation, and cheek flexibility in comparison to the placebo. The use of oral curcumin and lycopene appears to be effective and safe in the treatment of OL and OSF but to read the result of use of oral curcumin and lycopene in OL caution should be taken because of bias.<\/jats:p>","DOI":"10.4103\/njms.njms_324_21","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T02:35:41Z","timestamp":1639449341000},"page":"316-323","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["An overview of effect of lycopene and curcumin in oral leukoplakia and oral submucous fibrosis"],"prefix":"10.4103","volume":"12","author":[{"given":"TANVEER","family":"AHMAD","sequence":"first","affiliation":[{"name":"Department of Human Antomy, Faculty of Dentistry, Jamia Millia Islamia; Department of Biosciences, Jamia Millia Islamia, New Delhi, India"},{"name":"Department of Biosciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"IMRAN","family":"KHAN","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Jamia Millia Islamia, New Delhi, India"},{"name":"Oral and Maxillofacial Surgery, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M MOSHAHID","family":"RIZVI","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MOHD","family":"SAALIM","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Shri Bhausaheb Hire Government Medical College, Dhule, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NIKHAT","family":"MANZOOR","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Jamia Millia Islamia, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ASIA","family":"SULTANA","sequence":"additional","affiliation":[{"name":"Department of Ilaj Bit Tadbeer AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2021,12,13]]},"reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0560.1983.tb01490.x","article-title":"Oral leukoplakia and other white lesions of oralmucosa","volume":"10","author":"Banoczy","year":"1983","journal-title":"Cutaneous Pathol"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1111\/j.1600-0528.1985.tb00468.x","article-title":"Malignant transformation rate in oral submucous fibrosis over a 17-year period","volume":"13","author":"Murti","year":"1985","journal-title":"Community Dent Oral Epidemiol"},{"key":"R3-20250925","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1601-0825.2006.01349.x","article-title":"Molecular genetics of premalignant oral lesions","volume":"13","author":"Mithani","year":"2007","journal-title":"Oral Dis"},{"key":"R4-20250925","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S1368-8375(00)00140-8","article-title":"Impact of localized treatment in reducing risk of progression of low-grade oral dysplasia: Molecular evidence of incomplete resection","volume":"37","author":"Zhang","year":"2001","journal-title":"Oral Oncol"},{"key":"R5-20250925","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1368-8375(00)00070-1","article-title":"Trivandrum Oral Cancer Screening Study Group. 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