{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:27:59Z","timestamp":1787761679454,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Lymphomas are a group of malignant diseases affecting the lymphoreticular system. Lymphoma is the second most common neoplasm of the head and neck after squamous cell carcinoma, but the incidence of lymphomas in the oral cavity and orbit is rare. Non-Hodgkin\u2019s lymphoma (NHL) is less predictable than Hodgkin\u2019s but has a greater predilection to extranodal tissues. Non-Hodgkin\u2019s incidence in extranodal sites accounts for about 20% to 30%, but in the oral cavity, its around 0.1% to 5%. The rarity of incidence in the oral cavity and atypical radiographic features diagnosing a lymphoma is quite a challenge for clinicians. Here we describe a case of 31-year-old male patient with high-grade non-Hodgkin\u2019s lymphoma involving oral cavity with metastasis to orbit, skeletal structures, testes, liver, pancreas and nasopharynx, which is quite rare.<\/jats:p>","DOI":"10.4103\/njms.njms_497_21","type":"journal-article","created":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T06:34:30Z","timestamp":1681799670000},"page":"147-151","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["A rare case of high-grade non-Hodgkin\u2019s lymphoma with oral and multiple extranodal manifestations"],"prefix":"10.4103","volume":"14","author":[{"given":"Mohammed","family":"Faisal","sequence":"first","affiliation":[{"name":"Maxillofacial Surgeon, Mother Care Hospital, Mannarkad, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raha","family":"Mariyam","sequence":"additional","affiliation":[{"name":"Dental Surgeon, Calicut, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyothish","family":"Krishna","sequence":"additional","affiliation":[{"name":"Valluvanad Hospital Ottapalam, Palakkad, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binshad","family":"Basheer","sequence":"additional","affiliation":[{"name":"Department of Oral Maxillofacial Surgery, KMCT Dental College, Mukkam, Calicut, Kerala, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,4,14]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tripleo.2004.03.028","article-title":"Localized B-cell non-Hodgkin's lymphoma of oral cavity and maxillofacial region:A clinical study","volume":"99","author":"Kolokotronis","year":"2005","journal-title":"Oral Surg Oral Med Oral Path Oral Radiol Endod"},{"key":"R2-20240908","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ooe.2004.10.002","article-title":"Primary non Hodgkins lymphoma of the oral cavity","volume":"41","author":"Kobler","year":"2005","journal-title":"Oral Oncol Extra"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.tripleo.2007.02.019","article-title":"Oral non Hodgkin's lymphoma:Review of the literature and world health organization classification with reference to 40 cases","volume":"105","author":"Kemp","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R4-20240908","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0033-8389(22)01257-X","article-title":"Lymphoma of the head and neck","volume":"28","author":"DePena","year":"1990","journal-title":"Radiol Clin North Am"},{"key":"R5-20240908","first-page":"1299","article-title":"Non-Hodgkin's lymphoma (NHL) of the oral cavity","volume":"18","author":"Pecorari","year":"1998","journal-title":"Anticancer Res"},{"key":"R6-20240908","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0030-4220(83)90281-5","article-title":"Oral presentations in non-Hodgkin's lymphoma:A review of thirty-one cases. 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Data analysis","volume":"56","author":"Eisenbud","year":"1983","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"R7-20240908","doi-asserted-by":"crossref","first-page":"28","DOI":"10.18231\/j.ijmi.2021.007","article-title":"Non-Hodgkin's lymphoma with orbital, oral and systemic manifestations:A case report and review of literature","volume":"7","author":"Muthyam","year":"2021","journal-title":"IP Int J Maxillofacial Imaging"},{"key":"R8-20240908","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1067\/moe.2001.116062","article-title":"Characteristics of oral and paraoral malignant lymphoma:A population-based review of 361 cases","volume":"92","author":"Epstein","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"R9-20240908","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1053\/j.semnuclmed.2005.02.002","article-title":"Staging and classification of lymphoma","volume":"35","author":"Lu","year":"2005","journal-title":"Semin Nucl Med"},{"key":"R10-20240908","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1834-7819.2010.01212.x","article-title":"T-cell lymphoma of the oral cavity:A case report","volume":"55","author":"Villa","year":"2010","journal-title":"Aust Dent J"},{"key":"R11-20240908","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging classification","volume":"31","author":"Carbone","year":"1971","journal-title":"Cancer Res"},{"key":"R12-20240908","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijc.22719","article-title":"The non-Hodgkin lymphomas:A review of the epidemiologic literature","volume":"120","author":"Alexander","year":"2007","journal-title":"Int J Cancer"},{"key":"R13-20240908","first-page":"461","article-title":"The roles of human viruses in the pathogenesis of lymphoma","volume":"25","author":"Lyons","year":"1998","journal-title":"Semin Oncol"},{"key":"R14-20240908","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1445-5994.2007.01402.x","article-title":"Clinical perspectives in lymphoma","volume":"37","author":"Young","year":"2007","journal-title":"Intern Med J"},{"key":"R15-20240908","first-page":"21","article-title":"The diagnosis of AIDS and AIDS related complex in the dental office:Findings in 171 homosexual males","volume":"12","author":"Lozada-Nur","year":"1984","journal-title":"CDA J"},{"key":"R16-20240908","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1097\/00005537-200109000-00013","article-title":"Hodgkin's and non-Hodgkin's lymphoma of the head and neck","volume":"111","author":"Urquhart","year":"2001","journal-title":"Laryngoscope"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_497_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:02:14Z","timestamp":1787760134000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.njms_497_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/njms.njms_497_21","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"2021-11-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}