{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:35:54Z","timestamp":1787841354630,"version":"build-2784847793"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,7]]},"abstract":"\n Introduction:<\/jats:title>\n Vitamin D has been shown to play a vital role in bone mineral homeostasis by stimulating the intestinal absorption of calcium and phosphate. The critical role of Vitamin D in bone metabolism triggered the need to evaluate the effect of Vitamin D deficiency and hence replacement of the same on osseointegration of dental implants. This prospective study evaluated the crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A prospective clinical study was conducted on 32 patients based on the inclusion and exclusion criteria. Patients were divided into two groups on the basis of Vitamin D level < 30 ng\/ml (Group I: patients receiving Vitamin D3 supplements, i.e., cholecalciferol 1 g sachet 60,000 IU\/month) or <30 ng\/ml (Group II: not receiving Vitamin D3 supplements). The crestal bone level measurements were made with the help of Digimizer Image Analysis, MedCalc software.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n All implants showed clinically acceptable crestal bone level at interval of 1 week (baseline), 3 months, and 6 months. There was a statistically nonsignificant difference seen for the values between the groups (\n P<\/jats:italic>\n > 0.05) for all other values at various time intervals. However, there was a statistically significant\/highly significant difference seen for the values between the groups (\n P<\/jats:italic>\n < 0.01, 0.05) for 3 months distal with higher values for Group I as compared to Group II.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n From the study, it can be concluded that cholecalciferol has systemic effects on accelerating bone formation around titanium implant.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/njms.njms_49_20","type":"journal-article","created":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T08:40:48Z","timestamp":1608194448000},"page":"199-206","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Comparative evaluation of crestal bone level in patients having low level of Vitamin D treated with dental implant with or without Vitamin D3 supplements"],"prefix":"10.4103","volume":"11","author":[{"given":"Pooja","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Ghalaut","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Dahiya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reena","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshu","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Wakure","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Post Graduate Institute of Medical Sciences, Pt. B.D Sharma University of Health Sciences, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2020,12,16]]},"reference":[{"key":"R1-20250920","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1111\/clr.12439","article-title":"Fixed restorations supported by Morse-taper connection implants: A retrospective clinical study with 10-20 years of follow-up","volume":"26","author":"Mangano","year":"2015","journal-title":"Clin Oral Implants Res"},{"key":"R2-20250920","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/cid.12334","article-title":"Long-term survival of straumann dental implants with TPS surfaces: A retrospective study with a follow-up of 12 to 23 years","volume":"18","author":"Becker","year":"2016","journal-title":"Clin Implant Dent Relat Res"},{"key":"R3-20250920","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/jopr.12152","article-title":"Survival and complication rates of fixed restorations supported by locking-taper implants: A prospective study with 1 to 10 years of follow-up","volume":"23","author":"Mangano","year":"2014","journal-title":"J Prosthodont"},{"key":"R4-20250920","doi-asserted-by":"crossref","first-page":"35","DOI":"10.21608\/adjalexu.2015.58732","article-title":"The effect of cholecalciferol on titanium implant osseointegration","volume":"40","author":"Gaber","year":"2015","journal-title":"J Dent Alexandria"},{"key":"R5-20250920","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1359\/jbmr.060302","article-title":"A positive dose-response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: A double-blinded randomized placebo-controlled 1-year intervention","volume":"21","author":"Viljakainen","year":"2006","journal-title":"J Bone Miner Res"},{"key":"R6-20250920","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1056\/NEJM199709043371003","article-title":"Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older","volume":"337","author":"Dawson-Hughes","year":"1997","journal-title":"N Engl J Med"},{"key":"R7-20250920","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1111\/j.1600-0501.2008.01532.x","article-title":"Analysis of association of clinical aspects and vitamin D receptor gene polymorphism with dental implant loss","volume":"19","author":"Alvim-Pereira","year":"2008","journal-title":"Clin Oral Implants Res"},{"key":"R8-20250920","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"R9-20250920","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/2525-5711.20170014","article-title":"Influence of vitamin D in bone healing","volume":"2","author":"Freitas","year":"2017","journal-title":"J Oral Diag"},{"key":"R10-20250920","first-page":"1533","article-title":"Update on recent progress in vitamin D research. 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A retrospective clinical study on 1740 implants placed in 885 patients?","volume":"12","author":"Mangano","year":"2018","journal-title":"J Dent Res Dent Clin Dent Prospects"},{"key":"R31-20250920","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/j.1532-849X.2009.00446.x","article-title":"Vitamin D and bone physiology: Demonstration of vitamin D deficiency in an implant osseointegration rat model","volume":"18","author":"Kelly","year":"2009","journal-title":"J Prosthodont"}],"container-title":["National Journal of Maxillofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.NJMS_49_20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:51:14Z","timestamp":1787838674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/njms.NJMS_49_20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.4103\/njms.njms_49_20","relation":{},"ISSN":["0975-5950","2229-3418"],"issn-type":[{"value":"0975-5950","type":"print"},{"value":"2229-3418","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"2020-04-09","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}