{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T12:27:55Z","timestamp":1786969675473,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:00:00Z","timestamp":1786924800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pre-eclampsia is a pregnancy disorder linked with increased maternal and perinatal complications. An imbalance between free radical-induced lipid peroxidation and the antioxidant system may contribute to its pathogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to compare serum ceruloplasmin levels in women with pre-eclampsia and their normotensive counterparts and to assess its predictive value for disease severity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Subjects and Methods:<\/jats:title>\n                    <jats:p>\n                      A prospective case\u2013control study was conducted involving 100 pregnant women diagnosed with pre-eclampsia, matched for age and parity against 100 healthy controls. Patients with pre-eclampsia were classified into mild (55) and severe (45) pre-eclampsia groups. Data on demographics, obstetric characteristics and outcomes were collected. Ceruloplasmin protein concentration was measured using a competitive enzyme-linked immunosorbent assay kit. Data analysis was performed using Stata Version 17. The reference range of serum ceruloplasmin for determining the risk of pre-eclampsia was from the 2.5\n                      <jats:sup>th<\/jats:sup>\n                      to the 97.5\n                      <jats:sup>th<\/jats:sup>\n                      percentile of the controls. The statistical significance level was set at\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The median interquartile range (IQR) serum ceruloplasmin levels were 21 mg\/dL (IQR 17.5\u201323.8) in normotensive women, 35.5 mg\/dl (IQR, 33.8\u201338.3) in mild pre-eclampsia, and 46.5 mg\/dL (IQR, 42.5\u201349) in severe pre-eclampsia, with significant differences (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). The cut-off point for serum ceruloplasmin using Youden\u2019s index was 29 mg\/dL. Ceruloplasmin exhibited 90.8% sensitivity, 95.6% specificity and positive and negative predictive values and accuracy of 96.1%, 89.6% and 92.3%, respectively, in pre-eclampsia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serum ceruloplasmin was elevated in pre-eclampsia, and the levels correlate with the severity of pre-eclampsia. The sensitivity and specificity observed in this study suggest that ceruloplasmin may be a potential marker for discriminating between normotensive pregnant women and those with pre-eclampsia. Elevated levels may be an indicator of severe disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_175_25","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T04:00:26Z","timestamp":1786939226000},"page":"665-671","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Serum Ceruloplasmin in Pre-eclampsia: A Case\u2013Control Study in a Tertiary Health Centre in Southwest Nigeria"],"prefix":"10.4103","volume":"33","author":[{"given":"Joy Onyinyechi","family":"Chionuma","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, Lagos State University, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusegun Cosmos","family":"Adebara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nosimot Omolola","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Idi-Araba, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oladimeji Abiodun","family":"Makinde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Lagos State University Teaching Hospital, Ikeja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabiru Afolarin","family":"Rabiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, College of Medicine, Lagos State University, Lagos State University Teaching Hospital, Ikeja, 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