{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:17:28Z","timestamp":1787771848690,"version":"build-2784847793"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To evaluate the use of the Foetal Medicine Foundation (FMF) algorithm in routine practice for early pre-eclampsia (PE) screening in Libreville.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      We conducted a cohort study on pregnant women within their 11\u201313 + 6 weeks of gestation (WG). We had measured mean blood pressure (MBP), placental growth factor (PlGF), soluble Fms-like tyrosine kinase 1, Uterine Artery Pulsatility Index (UtA-PI) and resistance index (UtA-RI). Statistical analyses were considered significant for\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There were 30 participants. At the first quarter (T1), 36.7% of them were at high risk of PE according to the FMF algorithm and were consequently prescribed aspirin (100 mg\/d). By the end of the observation period, we have found a 13% incidence of PE. MBP was higher in the higher risk PE group than in the lower risk group as early as the T1 (90 \u00b1 6 vs. 81 \u00b1 6 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0007, threshold is &gt;86 mmHg\/area under the curve (AUC) = 0.86;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0012). It was the same for PlGF (58 \u00b1 24 vs. 88 \u00b1 38 pg\/ml;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03; threshold is &lt;71.98 pg\/ml\/AUC = 0.73;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.03). At the second quarter (20\u201327 WG), biochemical markers did not change between the two groups. UtA-RI, UtA-PI and notch were unconclusive individually, but they are still very important for FMF algorithm application.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Early detection of PE using the FMF algorithm is possible in routine practice in Gabon. MBP and PlGF levels at T1 seem to be very significant. However, the present study must continue to obtain the larger cohorts that would achieve more conclusive statistical analyses.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_232_23","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T02:02:08Z","timestamp":1707271328000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Added Value of Mean Blood Pressure and Placental Growth Factor in the Early Detection of Pre-eclampsia among Gabonese Women"],"prefix":"10.4103","volume":"31","author":[{"given":"Elisabeth","family":"Lendoye","sequence":"first","affiliation":[{"name":"Mother Pole, Laboratories Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"},{"name":"Department of Basic and Mixed Sciences, Chemistry-Biochemistry Service, Faculty of Medicine, University of Health Sciences, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulysse Pascal","family":"Minkobame","sequence":"additional","affiliation":[{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Opheelia","family":"Makoyo Komba","sequence":"additional","affiliation":[{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamphile","family":"Assoumou Obiang","sequence":"additional","affiliation":[{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luce","family":"Nkene Eya'a","sequence":"additional","affiliation":[{"name":"Mother Pole, Laboratories Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"},{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Bisvigou","sequence":"additional","affiliation":[{"name":"Department of Community and Social Health, Epidemiology of Chronic Diseases and Environmental Health Research Unit, Faculty of Medicine, University of Health Sciences, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Moukambi","sequence":"additional","affiliation":[{"name":"Mother Pole, Laboratories Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Ndeboko","sequence":"additional","affiliation":[{"name":"Mother Pole, Laboratories Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques Albert Bang","family":"Ntamack","sequence":"additional","affiliation":[{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgard Brice","family":"Ngoungou","sequence":"additional","affiliation":[{"name":"Department of Community and Social Health, Epidemiology of Chronic Diseases and Environmental Health Research Unit, Faculty of Medicine, University of Health Sciences, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl Fleury Djoba","family":"Siawaya","sequence":"additional","affiliation":[{"name":"Mother Pole, Laboratories Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix Ovono","family":"Abessolo","sequence":"additional","affiliation":[{"name":"Department of Basic and Mixed Sciences, Chemistry-Biochemistry Service, Faculty of Medicine, University of Health Sciences, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Fran\u00e7ois","family":"Mey\u00e9","sequence":"additional","affiliation":[{"name":"Mother Pole, Gynecology-Obstetric Service, Mother and Child University Hospital-Jeanne Ebori Foundation, Libreville, Gabon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,2,7]]},"reference":[{"key":"R2-20240908","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.preghy.2014.04.007","article-title":"Early and late-onset pre-eclampsia","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"issue":"Suppl 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