{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T17:22:20Z","timestamp":1783012940287,"version":"3.54.6"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Binswanger\u2019s disease, a rare form of subcortical vascular dementia, presents with a progressive decline in cognitive and motor functions due to chronic small vessel ischemic changes in the brain. Its clinical presentation often overlaps with other neurological conditions, particularly Wernicke\u2019s encephalopathy, leading to potential diagnostic delays. We report the case of a 45-year-old male who presented with altered mental status, gait abnormalities, memory impairment and ocular pain. Given his significant history of alcohol consumption, an imperial diagnosis of Wernicke\u2019s encephalopathy was made, and treatment was commenced with thiamine supplementation. However, the persistence of behavioural changes, right-sided pyramidal signs, extrapyramidal features and cognitive deficits prompted further evaluation. The clinical findings, combined with the patient\u2019s history of hypertension, diabetes and prior stroke, led to the diagnosis of Binswanger\u2019s disease. This case highlights the importance of considering vascular dementia in differential diagnoses of subacute encephalopathy and emphasises early recognition to initiate appropriate management.<\/jats:p>","DOI":"10.4103\/npmj.npmj_272_25","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:00:10Z","timestamp":1782968410000},"page":"539-542","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Binswanger\u2019s Disease: A Diagnostic Challenge in a Middle-aged Male"],"prefix":"10.4103","volume":"33","author":[{"given":"Mohd Faizan","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyanka","family":"Negandhi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sourya","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"reference":[{"key":"R1-20260702","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1586\/14737175.2014.956726","article-title":"Binswanger's disease: Diagnosis and management","volume":"14","author":"Huisa","year":"2014","journal-title":"Expert Rev Neurother"},{"key":"R2-20260702","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ncl.2007.04.003","article-title":"Subcortical Ischemic Vascular Dementia (SIVD)","volume":"25","author":"Chui","year":"2007","journal-title":"Neurol Clin"},{"key":"R3-20260702","doi-asserted-by":"crossref","first-page":"e001140","DOI":"10.1161\/JAHA.114.001140","article-title":"What are white matter hyperintensities made of?","volume":"4","author":"Wardlaw","year":"2015","journal-title":"J Am Heart Assoc Cardiovasc Cerebrovasc 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