{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:35Z","timestamp":1786653455204,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background:<\/jats:title>\n Breast cancer remains the most prevalent malignancy among women worldwide, contributing significantly to global cancer-related morbidity and mortality. It is responsible for nearly 15% of all female cancer fatalities. It has a higher prevalence in developed nations.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n The present study aimed to assess the predictive utility of Atherogenic index of plasma (AIP) in carcinoma breast cases in correlation with oxidative stress, immuno-biomarkers and body mass index (BMI).<\/jats:p>\n <\/jats:sec>\n \n Subjects and Methods:<\/jats:title>\n \n Prospective interventional study. The Prospective Interventional Study was conducted in the Department of Biochemistry, Jawaharlal Nehru Medical College and the Histopathology and Radiology division of the Department of Pathology, JNMC, in collaboration with the Department of Surgery, JNMC and Acharya Vinoba Bhave Rural Hospital, Wardha, for the duration of 3 years. Total 81 samples were recruited for the study. The patient\u2019s history was taken, and a proper medical examination was carried out. The SPSS program for Windows, version 26.0 (SPSS, Chicago, Illinois, USA), was employed to conduct the statistical analysis. Categorical variables were analysed using either the Chi-square test or Fisher\u2019s exact test, while continuous variables were compared using the unpaired\n t<\/jats:italic>\n -testing method.\n P<\/jats:italic>\n \u22640.05 was deemed to be statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A significant positive correlations between AIP and various parameters, including BMI (\n r<\/jats:italic>\n = 0.591,\n P<\/jats:italic>\n < 0.001), superoxide dismutase (\n r<\/jats:italic>\n = 0.407,\n P<\/jats:italic>\n < 0.001), high-sensitivity C-reactive protein (\n r<\/jats:italic>\n = 0.507,\n P<\/jats:italic>\n < 0.001), Interleukin-10 (IL-10) (\n r<\/jats:italic>\n = 0.706,\n P<\/jats:italic>\n < 0.001) and IL-18 (\n r<\/jats:italic>\n = 0.652,\n P<\/jats:italic>\n < 0.001). Furthermore, a strong positive correlation with lipid profile was observed.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n AIP could serve as a useful surrogate marker to assess not only lipid imbalance but also broader systemic changes that accompany breast cancer.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/npmj.npmj_279_25","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:01:26Z","timestamp":1777611686000},"page":"353-357","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Predictive Utility of Atherogenic Index of Plasma in Carcinoma Breast Cases in Correlation with Oxidative Stress, Immuno-biomarkers and Body Mass Index"],"prefix":"10.4103","volume":"33","author":[{"given":"Abhishek","family":"Pant","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Anjankar","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Jawahar Lal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"R1-20260501","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J Clin"},{"key":"R2-20260501","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.7150\/ijbs.21635","article-title":"Risk factors and preventions of breast cancer","volume":"13","author":"Sun","year":"2017","journal-title":"Int J Biol Sci"},{"key":"R3-20260501","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1210\/clinem\/dgac241","article-title":"Obesity and breast cancer risk: The oncogenic implications of metabolic dysregulation","volume":"107","author":"Naaman","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-20260501","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.jacl.2010.02.005","article-title":"Atherogenic index of plasma (log10 triglyceride\/high-density lipoprotein-cholesterol) predicts high blood pressure, diabetes, and vascular events","volume":"4","author":"Onat","year":"2010","journal-title":"J Clin Lipidol"},{"key":"R5-20260501","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.3390\/cancers15235565","article-title":"The role of apolipoproteins in the commonest cancers: A review","volume":"15","author":"Darwish","year":"2023","journal-title":"Cancers (Basel)"},{"key":"R6-20260501","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3390\/antiox10050642","article-title":"Oxidative stress in cancer cell metabolism","volume":"10","author":"Arfin","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"R7-20260501","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12933-021-01393-5","article-title":"Atherogenic index of plasma is associated with major adverse cardiovascular events in patients with type 2 diabetes mellitus","volume":"20","author":"Fu","year":"2021","journal-title":"Cardiovasc Diabetol"},{"key":"R8-20260501","first-page":"e39990","article-title":"Clinicopathological profile of breast cancer at a tertiary cancer center in Jharkhand, India: A descriptive cohort study","volume":"15","author":"Upadhyay","year":"2023","journal-title":"Cureus"},{"key":"R9-20260501","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.4103\/jcrt.JCRT_868_16","article-title":"Epidemiological characteristics of breast cancer patients attending a tertiary health-care institute in the national capital territory of India","volume":"15","author":"Sofi","year":"2019","journal-title":"J Cancer Res Ther"},{"key":"R10-20260501","first-page":"e13242","article-title":"Factors associated with treatment delay in breast cancer: A prospective study","volume":"13","author":"Rahool","year":"2021","journal-title":"Cureus"},{"key":"R11-20260501","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/annonc\/mdr589","article-title":"Dietary fiber and breast cancer risk: A systematic review and meta-analysis of prospective studies","volume":"23","author":"Aune","year":"2012","journal-title":"Ann Oncol"},{"key":"R12-20260501","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1001\/jama.2017.7112","article-title":"Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers","volume":"317","author":"Kuchenbaecker","year":"2017","journal-title":"JAMA"},{"key":"R13-20260501","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/jnci\/djt095","article-title":"Cancer risks for BRCA1 and BRCA2 mutation carriers: Results from prospective analysis of EMBRACE","volume":"105","author":"Mavaddat","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"R14-20260501","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0140-6736(14)60892-8","article-title":"Body-mass index and risk of 22 specific cancers: A population-based cohort study of 5\u00b724 million UK adults","volume":"384","author":"Bhaskaran","year":"2014","journal-title":"Lancet"},{"key":"R15-20260501","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0140-6736(08)60269-X","article-title":"Body-mass index and incidence of cancer: A systematic review and meta-analysis of prospective observational studies","volume":"371","author":"Renehan","year":"2008","journal-title":"Lancet"},{"key":"R16-20260501","doi-asserted-by":"crossref","first-page":"10631","DOI":"10.1038\/s41598-022-13740-x","article-title":"Association of lipid profile biomarkers with breast cancer by molecular subtype: Analysis of the MEND study","volume":"12","author":"Gupta","year":"2022","journal-title":"Sci Rep"},{"key":"R17-20260501","doi-asserted-by":"crossref","first-page":"3000605211061033","DOI":"10.1177\/03000605211061033","article-title":"Association between serum lipids and breast cancer risk in premenopausal women: Systematic review and meta-analysis","volume":"49","author":"Wu","year":"2021","journal-title":"J Int Med Res"},{"key":"R18-20260501","first-page":"510","article-title":"Epidemiologic correlates of breast cancer laterality (Sweden)","volume":"5","author":"Ekbom","year":"1994","journal-title":"Cancer Causes Control"},{"key":"R19-20260501","first-page":"53","article-title":"Clinicopathological profile of breast cancer in North India: A study from a tertiary hospital with review of literature","volume":"2","author":"Agarwal","year":"2015","journal-title":"IJSAR"},{"key":"R20-20260501","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1080\/01411590310001637066","article-title":"Antioxidant enzymes and lipid peroxidation in different stages of breast cancer","volume":"38","author":"Khanzode","year":"2004","journal-title":"Free Radic Res"},{"key":"R21-20260501","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12933-024-02198-y","article-title":"The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis","volume":"23","author":"Rabiee","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"R22-20260501","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12944-023-01853-9","article-title":"Association between atherogenic index of plasma and prehypertension or hypertension among normoglycemia subjects in a Japan population: A cross-sectional study","volume":"22","author":"Tan","year":"2023","journal-title":"Lipids Health Dis"},{"key":"R23-20260501","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0009-9120(01)00263-6","article-title":"The plasma parameter log (TG\/HDL-C) as an atherogenic index: Correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER (HDL))","volume":"34","author":"Dobi\u00e1sov\u00e1","year":"2001","journal-title":"Clin Biochem"}],"container-title":["Nigerian Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_279_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:46Z","timestamp":1786649866000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_279_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/npmj.npmj_279_25","relation":{},"ISSN":["1117-1936","2468-6875"],"issn-type":[{"value":"1117-1936","type":"print"},{"value":"2468-6875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-06-13","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}