{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:36:01Z","timestamp":1786649761662,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Suxamethonium, a rapid-acting muscle relaxant, has been conventionally preferred during rapid sequence induction (RSI). The priming principle, which uses non-depolarising muscle relaxants, is an alternative in situations where it is contraindicated. Unfortunately, its efficacy has not been sufficiently documented in Nigerian patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>The study aimed to use atracurium and pacuronium to evaluate the efficacy of the priming principle.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In this randomised controlled trial, ninety adults undergoing elective surgery under general anaesthesia were randomly allocated into three equal groups. Group A (Atracurium), Group P (Pancuronium) and Group C (control) received 0.05 mg\/kg atracurium, 0.01 mg\/kg pancuronium and 1 ml saline, respectively, as the priming agent. Three minutes after, anaesthesia was induced with 2 mg\/kg propofol and then the intubating dose of pancuronium administered. The onset time of neuromuscular block, intubating condition and occurrence of muscle weakness during the priming interval were noted. Data were analysed using the Statistical Package for the Social Sciences version 25, and a\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean onset time in Groups A, P and C was 215.7 \u00b1 59.9 s, 237.1 \u00b1 76.5 s and 265.8 \u00b1 72.0 s, respectively,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.024.\n                      <jats:italic toggle=\"yes\">Post hoc<\/jats:italic>\n                      analysis showed that the onset time was only significant between Groups A and C (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02). The intubating condition was comparable in all groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.25). The incidence of muscle weakness during the priming interval was 6.67% in the priming groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In adults, priming with atracurium but not pancuronium shortens the onset time of pancuronium. However, during RSI, where a fast onset is crucial, the shortened onset time with priming is not clinically relevant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_306_25","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:00:18Z","timestamp":1767337218000},"page":"52-57","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Priming with Atracurium or Pancuronium on the Onset Time of Pancuronium in Patients Undergoing General Anesthesia for Elective Surgery: A Randomised Controlled Trial"],"prefix":"10.4103","volume":"33","author":[{"given":"Thankgod Chukwunnonso","family":"Okonkwo","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, University College Hospital, Ibadan, Nigeria"},{"name":"Duchess International Hospital, Ikeja, Lagos, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinuola Abiodun","family":"Adigun","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, University College Hospital, Ibadan, Nigeria"},{"name":"Department of Anaesthesia and Intensive Care, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olusola Kayode","family":"Idowu","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, University College Hospital, Ibadan, Nigeria"},{"name":"Department of Anaesthesia and Intensive Care, College of Medicine, University of Ibadan, Ibadan, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1213\/ANE.0b013e3181d5ae47","article-title":"Rapid sequence induction and 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