{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:35:58Z","timestamp":1786649758240,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pulse pressure index (PPI) and high-sensitivity C-reactive protein (hs-CRP) are potential markers for vascular compliance and inflammation, respectively, and may predict diastolic dysfunction in hypertensive individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to evaluate the association of PPI and hs-CRP with diastolic dysfunction in newly diagnosed essential hypertensive patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This prospective observational study included 82 patients aged &gt;40 years with newly diagnosed hypertension. Baseline PPI and hs-CRP levels were measured, and two-dimensional echocardiography was performed to assess and grade DD. Patients received standard antihypertensive therapy, and follow-ups were conducted at 3 and 6 months to reassess parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      At baseline, 74.4% of patients had diastolic dysfunction, predominantly Grade 1 and 2. hs-CRP showed a strong positive association with diastolic dysfunction (\u03b2 = 0.885,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.025), while PPI had a moderate correlation (\u03b2 = 0.475,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.035). Antihypertensive therapy significantly improved diastolic function over 6 months (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.032), though PPI did not show a significant change (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.435).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>hs-CRP is a strong indicator of inflammation-driven diastolic dysfunction, while PPI serves as a surrogate for vascular stiffness. Early identification using these markers can enhance clinical assessment and guide timely intervention in hypertensive patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_403_25","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:00:31Z","timestamp":1772434831000},"page":"207-212","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Correlation of Pulse Pressure Index and High-sensitivity C-reactive Protein as Predictors of Diastolic Dysfunction in Essential Hypertension \u2013 A Prospective Observational Study at a Tertiary Care Centre in Chengalpattu"],"prefix":"10.4103","volume":"33","author":[{"given":"Taruguvandla Sandhya","family":"Rani","sequence":"first","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi Teja","family":"Nalabothula","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subramaniyan","family":"Kumarasamy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardhana Subramonia","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmukha Sai","family":"Bolisetty","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre Kattankulathur, Chengalpattu, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1161\/01.CIR.101.3.329","article-title":"Essential hypertension. 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