{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:01Z","timestamp":1787775661087,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>Poikilodermatous skin changes represent a diagnostic challenge due to their non-specific clinical features and broad differential diagnoses. This report presents the case of a 29-year-old female with symmetrical, variably pigmented macules and patches over sun-exposed areas, including the neck and upper limbs. Histopathological examination revealed epidermal atrophy, pigment incontinence, basal layer pigmentation, dermal telangiectasia and a mild lymphocytic infiltrate \u2013 findings consistent with poikilodermatous change. No features suggestive of interface dermatitis, atypical lymphoid cells or basal vacuolar alteration were observed, effectively ruling out conditions such as cutaneous T-cell lymphoma, connective tissue disease and lichen planus pigmentosus. In the absence of systemic symptoms or alarming histological features, a diagnosis of benign acquired poikiloderma, likely actinic in origin, was favoured. This case underscores the critical role of histopathological correlation in accurately diagnosing poikilodermatous lesions and guiding appropriate clinical management.<\/jats:p>","DOI":"10.4103\/npmj.npmj_413_25","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:00:35Z","timestamp":1772434835000},"page":"276-279","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Poikilodermatous Change of Skin: Diagnostic Insights from Clinical and Histopathological Examination"],"prefix":"10.4103","volume":"33","author":[{"given":"Abhishek Ghose","family":"Biswas","sequence":"first","affiliation":[{"name":"Department of Pathology, Datta Meghe Institute of Higher Education and Research, Jawaharlal Nehru Medical College, Wardha, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"R1-20260420","doi-asserted-by":"crossref","first-page":"27","DOI":"10.18535\/jmscr\/v9i8.07","article-title":"Poikilodermatous mycosis fungoides","volume":"9","author":"Gupta","year":"2021","journal-title":"J Med Sci Clin Res"},{"key":"R2-20260420","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/ddg.14360","article-title":"Poikilodermatous lichen planus pigmentosus: A clinico-histopathological study","volume":"19","author":"Alakad","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"R3-20260420","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000098580","article-title":"Poikiloderma of civatte: A histopathological and ultrastructural study","volume":"214","author":"Katoulis","year":"2007","journal-title":"Dermatology"},{"key":"R4-20260420","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/j.1346-8138.1998.tb02492.x","article-title":"Poikiloderma-like cutaneous amyloidosis in an ethnic Chinese girl","volume":"25","author":"Ho","year":"1998","journal-title":"J Dermatol"},{"key":"R5-20260420","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5005\/jp-journals-10061-0006","article-title":"Dermoscopy of poikilodermatous mycosis fungoides in pigmented skin","volume":"1","author":"Bharti","year":"2017","journal-title":"International Journal of Dermoscopy"},{"key":"R6-20260420","first-page":"37","article-title":"Poikilodermatous mycosis fungoides: Clinical and histopathological analysis of a case and literature review","volume":"24","author":"Pankratov","year":"2015","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"R7-20260420","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1111\/ijd.15498","article-title":"Inherited skin disorders presenting with poikiloderma","volume":"60","author":"Rayinda","year":"2021","journal-title":"Int J Dermatol"}],"container-title":["Nigerian Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_413_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:48Z","timestamp":1787773068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_413_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/npmj.npmj_413_25","relation":{},"ISSN":["1117-1936","2468-6875"],"issn-type":[{"value":"1117-1936","type":"print"},{"value":"2468-6875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-08-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}