{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:35Z","timestamp":1786653455207,"version":"build-2736575974"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"\n Background:<\/jats:title>\n Cirrhosis of the liver is a chronic condition characterised by scar tissue replacing healthy liver tissue, leading to impaired liver function and endocrine disturbances. Hyperprolactinemia in cirrhosis results from reduced dopamine inhibition due to elevated circulating oestrogens.<\/jats:p>\n <\/jats:sec>\n \n Aims:<\/jats:title>\n This study assessed the relationship between serum prolactin levels and the Child\u2013Pugh scoring system in predicting complications in liver cirrhosis.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A cross-sectional study was conducted on 70 cirrhotic patients over 12 months at a tertiary care center. Inclusion criteria included patients aged \u226518 years with diagnosed cirrhosis. Serum prolactin levels were measured using radioimmunoassay. Disease severity was evaluated using the Child\u2013Pugh scoring system. Statistical analysis was performed to assess correlations between prolactin levels, Child\u2013Pugh scores and clinical complications.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Serum prolactin levels showed a strong positive correlation with the Child\u2013Pugh score (\n r<\/jats:italic>\n = 0.641,\n P<\/jats:italic>\n < 0.001). Elevated prolactin levels were associated with complications such as ascites, portal hypertension, hepatic encephalopathy and oesophageal varices (\n P<\/jats:italic>\n < 0.001). Patients with higher prolactin levels demonstrated significantly increased 6-month mortality (\n P<\/jats:italic>\n < 0.0001). Receiver operating characteristic curve analysis (area under the curve = 0.98) highlighted prolactin\u2019s predictive value for mortality.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Serum prolactin is a reliable biomarker for assessing cirrhosis severity and predicting complications. It complements the Child\u2013Pugh scoring system and may guide early interventions in high-risk patients.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/npmj.npmj_469_25","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:01:48Z","timestamp":1777611708000},"page":"322-327","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Serum Prolactin Level with Child\u2013Pugh Scoring System in Predicting the Complications of Cirrhosis of Liver: A Cross-sectional Study"],"prefix":"10.4103","volume":"33","author":[{"given":"Allu Ravi","family":"Kishor","sequence":"first","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manne Lakshmi Narasimha","family":"Sandeep","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthi","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardhanan Subramonia","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siva Prakash","family":"Sethupathi","sequence":"additional","affiliation":[{"name":"Department of General Medicine, SRM Medical College Hospital and Research Centre, Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,5,1]]},"reference":[{"key":"R1-20260501","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.jceh.2022.04.021","article-title":"Overview of complications in cirrhosis","volume":"12","author":"Premkumar","year":"2022","journal-title":"J Clin Exp Hepatol"},{"key":"R6-20260501","first-page":"1","article-title":"acute kidney injury during cirrhosis: A prospective study in Dakar","volume":"7","author":"AliouneBadara","year":"2024","journal-title":"Gastroint Hepatol Dig Dis"},{"key":"R7-20260501","first-page":"13","article-title":"Spontaneous bacterial peritonitis in patients with cirrhosis: Incidence, outcomes, and treatment strategies","volume":"11","author":"Marciano","year":"2019","journal-title":"Hepat Med"},{"key":"R8-20260501","doi-asserted-by":"crossref","first-page":"58","DOI":"10.36347\/sasjm.2022.v08i02.002","article-title":"Child-pugh score of decompensated chronic liver disease patient as a predictor of short-term prognosis","volume":"8","author":"Baker","year":"2022","journal-title":"SAS J Med"},{"key":"R9-20260501","first-page":"C30","article-title":"Correlation of serum prolactin level to child Pugh scoring system in cirrhosis of liver","volume":"11","author":"Balakrishnan","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"R10-20260501","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/apt.16489","article-title":"Review article: Time to revisit Child-Pugh score as the basis for predicting drug clearance in hepatic impairment","volume":"54","author":"El-Khateeb","year":"2021","journal-title":"Aliment Pharmacol Ther"},{"key":"R11-20260501","doi-asserted-by":"crossref","first-page":"e12888","DOI":"10.1111\/jne.12888","article-title":"Metabolic functions of prolactin: Physiological and pathological aspects","volume":"32","author":"Lopez-Vicchi","year":"2020","journal-title":"J Neuroendocrinol"}],"container-title":["Nigerian Postgraduate Medical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_469_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:49Z","timestamp":1786649869000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/npmj.npmj_469_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/npmj.npmj_469_25","relation":{},"ISSN":["1117-1936","2468-6875"],"issn-type":[{"value":"1117-1936","type":"print"},{"value":"2468-6875","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"2025-09-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-12","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}