{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:37:28Z","timestamp":1786653448265,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Polycystic ovarian syndrome (PCOS) has bidirectional effects on the skeleton due to hormonal dysfunction and insulin resistance (IR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>We examined bone mineral density (BMD) and its relationship with IR using the homeostasis model of assessment (HOMA) in patients with PCOS and matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      In this case\u2013control observational study, we included 74 patients newly diagnosed with PCOS and a similar number of age-and weight-matched healthy women as controls. Haematological, biochemical and hormonal parameters were measured in a fasting blood sample during the follicular phase, and the BMD\n                      <jats:italic toggle=\"yes\">Z<\/jats:italic>\n                      score was calculated using dual energy X-ray absorptiometry. The results were analysed using relevant statistical methods, and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was considered significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The study participants (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 148) had a mean age of 23.6 \u00b1 3.7 years and a body mass index (BMI) of 25.2 \u00b1 3.2 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      . Among the PCOS patients, 25 (34%) had a normal BMI and 49 (66%) were obese. The BMD at the femoral neck (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.4313) and lumbar spine (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.1410) was comparable between the PCOS and control groups. Correlation analysis showed a positive correlation of BMD with testosterone and 17-hydroxy progesterone (17OHP) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). None of the BMD parameters correlated with HOMA in either group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>BMD at the lumbar spine and femoral neck was similar between patients with PCOS and controls. Further studies with a larger sample size, longer follow-up periods and fracture data are needed to confirm our findings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_579_25","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T05:00:59Z","timestamp":1777611659000},"page":"306-310","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association between Bone Mineral Density and Insulin Resistance in Polycystic Ovarian Syndrome \u2013 A Case\u2013control Observational Study"],"prefix":"10.4103","volume":"33","author":[{"given":"Anushri","family":"Sridharan","sequence":"first","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun","family":"Guddeti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayyad","family":"Aleem","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sai Ramya","family":"Vasamsetti","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sravanthi","family":"Mashetty","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lalitha A. V.","family":"Alekya","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, ESIC Medical College and Hospital, Hyderabad, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. V. S. 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