{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:16:50Z","timestamp":1783016210124,"version":"3.54.6"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Acute calculous cholecystitis (ACC) is a common surgical emergency. The optimal timing for laparoscopic cholecystectomy (LC) remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study compared outcomes between early LC (ELC) and interval LC (ILC) for ACC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A prospective randomised controlled trial was conducted with 100 patients equally allocated to ELC (within 72 h) or ILC (6\u20138 weeks post-conservative management). Primary outcomes included operative time, conversion rate and total hospital stay. Secondary outcomes assessed intraoperative events and post-operative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Mean operative time was significantly longer in the ELC group (95.47 min vs. 73.69 min,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.001). Total hospital stay was shorter with ELC (6.50 days vs. 10.80 days,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009). Conversion rates were higher in the ILC group (18% vs. 8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.245). Bile duct injuries occurred exclusively in the ELC group (8% vs. 0%). Significant intraoperative bleeding (80% vs. 56%) and total postoperative complications (30% vs. 8%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.006) were more frequent with ELC.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>ELC reduces hospital stay but is associated with longer operative times and higher complication rates. ILC may offer a safer operative field but extends overall treatment duration. Timing should be individualised based on patient factors, surgical expertise and institutional resources, with stringent adherence to safety principles.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/npmj.npmj_67_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:00:37Z","timestamp":1782968437000},"page":"443-450","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A Randomised Controlled Trial Comparing Early versus Interval Laparoscopic Cholecystectomy for Acute Calculous Cholecystitis: A Study of Feasibility and Outcomes"],"prefix":"10.4103","volume":"33","author":[{"given":"Anil","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of General Surgery, Uttar Pradesh University of Medical Sciences, Etawah, Uttar Pradesh, 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