{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:56:12Z","timestamp":1791557772690,"version":"4.3.4"},"reference-count":192,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Alzheimer\u2019s disease is the primary cause of dementia and imposes a significant socioeconomic burden globally. Physical exercise, as an effective strategy for improving general health, has been largely reported for its effectiveness in slowing neurodegeneration and increasing brain functional plasticity, particularly in aging brains. However, the underlying mechanisms of exercise in cognitive aging remain largely unclear. Adiponectin, a cell-secreted protein hormone, has recently been found to regulate synaptic plasticity and mediate the antidepressant effects of physical exercise. Studies on the neuroprotective effects of adiponectin have revealed potential innovative treatments for Alzheimer\u2019s disease. Here, we reviewed the functions of adiponectin and its receptor in the brains of human and animal models of cognitive impairment. We summarized the role of adiponectin in Alzheimer\u2019s disease, focusing on its impact on energy metabolism, insulin resistance, and inflammation. We also discuss how exercise increases adiponectin secretion and its potential benefits for learning and memory. Finally, we highlight the latest research on chemical compounds that mimic exercise-enhanced secretion of adiponectin and its receptor in Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-00943","type":"journal-article","created":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T02:00:10Z","timestamp":1738288810000},"page":"96-106","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["Adiponectin as a potential mediator of the pro-cognitive effects of physical exercise on Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"21","author":[{"given":"Hui-Hui","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, China"},{"name":"Department of Rehabilitation Medicine, Shaoxing People\u2019s Hospital, Shaoxing, Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Ning","family":"Ou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, China"},{"name":"Department of Rehabilitation, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province, China"},{"name":"The Second Institute of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Sui","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia Macedo","family":"Rosa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Affonso","family":"Formolo","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-6741","authenticated-orcid":false,"given":"Suk-Yu","family":"Yau","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3003-8598","authenticated-orcid":false,"given":"Hector Wing Hong","family":"Tsang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, China"},{"name":"Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"},{"name":"Mental Health Research Center, The Hong Kong Polytechnic University, Hong Kong Special Administrative Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.3390\/ijms21072620","article-title":"Adiponectin and its mimics on skeletal muscle: insulin sensitizers, fat burners, exercise mimickers, muscling pills \u2026 or everything together?","volume":"21","author":"Abou-Samra","year":"2020","journal-title":"Int J Mol Sci"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"7480579","DOI":"10.1155\/2022\/7480579","article-title":"Adiponectin and nitric oxide deficiency-induced 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