{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:28Z","timestamp":1792167748567,"version":"4.4.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202508000-00030\/figure1\/v\/2026-04-27T065324Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Retinitis pigmentosa is a group of inherited diseases that lead to retinal degeneration and photoreceptor cell death. However, there is no effective treatment for retinitis pigmentosa caused by\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    mutation. Adeno-associated virus (AAV)-mediated gene therapy is a promising strategy for treating retinitis pigmentosa. The aim of this study was to explore the molecular mechanisms by which AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    rescues retinal function. To do this, we injected retinal degeneration 10 (rd10) mice subretinally with AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    and assessed the therapeutic effects on retinal function and structure using dark- and light-adapted electroretinogram, optical coherence tomography, and immunofluorescence. Data-independent acquisition-mass spectrometry-based proteomic analysis was conducted to investigate protein expression levels and pathway enrichment, and the results from this analysis were verified by real-time polymerase chain reaction and western blotting. AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    injection significantly upregulated PDE6\u03b2 expression, preserved electroretinogram responses, and preserved outer nuclear layer thickness in rd10 mice. Differentially expressed proteins between wild-type and rd10 mice were closely related to visual perception, and treating rd10 mice with AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    restored differentially expressed protein expression to levels similar to those seen in wild-type mice. Kyoto Encyclopedia of Genes and Genome analysis showed that the differentially expressed proteins whose expression was most significantly altered by AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    injection were enriched in phototransduction pathways. Furthermore, the phototransduction-related proteins Pde6\u03b1, Rom1, Rho, Aldh1a1, and Rbp1 exhibited opposite expression patterns in rd10 mice with or without AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    treatment. Finally, Bax\/Bcl-2, p-ERK\/ERK, and p-c-Fos\/c-Fos expression levels decreased in rd10 mice following AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    treatment. Our data suggest that AAV2-\n                    <jats:italic toggle=\"yes\">PDE6B<\/jats:italic>\n                    -mediated gene therapy promotes phototransduction and inhibits apoptosis by inhibiting the ERK signaling pathway and upregulating Bcl-2\/Bax expression in retinitis pigmentosa.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01301","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T08:00:32Z","timestamp":1713945632000},"page":"2408-2419","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":11,"title":["AAV2-PDE6B restores retinal structure and function in the retinal degeneration 10 mouse model of retinitis pigmentosa by promoting phototransduction and inhibiting apoptosis"],"prefix":"10.4103","volume":"20","author":[{"given":"Ruiqi","family":"Qiu","sequence":"first","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzhu","family":"Yang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuxiu","family":"Jin","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"},{"name":"Branch of National Clinical Research Center for Ocular Disease, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyang","family":"Liu","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Han","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5497-0905","authenticated-orcid":false,"given":"Bo","family":"Lei","sequence":"additional","affiliation":[{"name":"Henan Eye Hospital, Henan Provincial People\u2019s Hospital, People\u2019s Hospital of Zhengzhou University, Zhengzhou, Henan Province, China"},{"name":"Eye Institute, Henan Academy of Innovations in Medical Science, Zhengzhou, Henan Province, China"},{"name":"Branch of National Clinical Research Center for Ocular Disease, Henan Provincial People\u2019s Hospital, Zhengzhou, Henan Province, China"},{"name":"Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"R1-20260427","doi-asserted-by":"crossref","first-page":"5713","DOI":"10.1167\/iovs.10-6269","article-title":"AAV-mediated gene replacement, either alone or in combination with physical and pharmacological agents, results in partial and transient protection from photoreceptor degeneration associated with betaPDE deficiency","volume":"52","author":"Allocca","year":"2011","journal-title":"Invest 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