{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:42:29Z","timestamp":1786725749600,"version":"build-2736575974"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202506000-00025\/figure1\/v\/2026-05-07T073243Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post\u2013traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A (\n                    <jats:italic toggle=\"yes\">Dip2a<\/jats:italic>\n                    ) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid\u2013associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that\n                    <jats:italic toggle=\"yes\">Dip2a<\/jats:italic>\n                    deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally,\n                    <jats:italic toggle=\"yes\">Dip2a<\/jats:italic>\n                    was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of\n                    <jats:italic toggle=\"yes\">Dip2a<\/jats:italic>\n                    in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01871","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T12:00:27Z","timestamp":1715342427000},"page":"1735-1748","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Dip2a regulates stress susceptibility in the basolateral amygdala"],"prefix":"10.4103","volume":"20","author":[{"given":"Jing","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Epigenetics, Ministry of Education; Institute of Genetics and Cytology, Northeast Normal University, Changchun, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"He","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Epigenetics, Ministry of Education; Institute of Genetics and Cytology, 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