{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T14:43:56Z","timestamp":1793198636189,"version":"4.5.0"},"reference-count":58,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202511000-00034\/figure1\/v\/2026-04-24T022020Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Previous studies have shown that the compound (\n                    <jats:italic toggle=\"yes\">E<\/jats:italic>\n                    )-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one (D30), a pyromeconic acid derivative, possesses antioxidant and anti-inflammatory properties, inhibits amyloid-\u03b2 aggregation, and alleviates scopolamine-induced cognitive impairment, similar to the phase III clinical drug resveratrol. In this study, we established a mouse model of Alzheimer\u2019s disease via intracerebroventricular injection of fibrillar amyloid-\u03b2 to investigate the effect of D30 on fibrillar amyloid-\u03b2\u2013induced neuropathology. Our results showed that D30 alleviated fibrillar amyloid-\u03b2\u2013induced cognitive impairment, promoted fibrillar amyloid-\u03b2 clearance from the hippocampus and cortex, suppressed oxidative stress, and inhibited activation of microglia and astrocytes. D30 also reversed the fibrillar amyloid-\u03b2\u2013induced loss of dendritic spines and synaptic protein expression. Notably, we demonstrated that exogenous fibrillar amyloid-\u03b2 introduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain, and this increase was blocked by D30. Considering the role of D30 in clearing amyloid-\u03b2, inhibiting neuroinflammation, protecting synapses, and improving cognition, this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer\u2019s disease.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01890","type":"journal-article","created":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T14:00:51Z","timestamp":1734962451000},"page":"3330-3344","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["The compound (E)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7229-2810","authenticated-orcid":false,"given":"Xueyan","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7914-1054","authenticated-orcid":false,"given":"Wei","family":"Wu","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Laboratory Animal Center, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Chai","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanru","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxing","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-9217","authenticated-orcid":false,"given":"Chenlu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neurosurgery Research Institute, The First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Department of Hyperbaric Oxygen, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5851-3261","authenticated-orcid":false,"given":"Zu-Cheng","family":"Ye","sequence":"additional","affiliation":[{"name":"Fujian Provincial Key Laboratory of Brain Aging and Neurodegenerative Diseases, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0377-8913","authenticated-orcid":false,"given":"Daijun","family":"Zha","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"R1-20260424","doi-asserted-by":"crossref","first-page":"9583","DOI":"10.3390\/ijms22179583","article-title":"Deciphering the potential neuroprotective effects of luteolin against A\u03b2(1)-(42)-induced Alzheimer\u2019s disease","volume":"22","author":"Ahmad","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R2-20260424","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s40035-023-00338-0","article-title":"Targeting galectin-3 to counteract spike-phase uncoupling of fast-spiking interneurons to gamma oscillations in Alzheimer\u2019s disease","volume":"12","author":"Arroyo-Garc\u00eda","year":"2023","journal-title":"Transl Neurodegener"},{"key":"R3-20260424","doi-asserted-by":"crossref","first-page":"768","DOI":"10.3390\/antiox9080768","article-title":"Cotinine and 6-hydroxy-l-nicotine reverses memory deficits and reduces oxidative stress in A\u03b2(25-35)-induced rat model of Alzheimer\u2019s disease","volume":"9","author":"Boiangiu","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"R4-20260424","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00401-019-02013-z","article-title":"Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer\u2019s disease","volume":"138","author":"Boza-Serrano","year":"2019","journal-title":"Acta Neuropathol"},{"key":"R5-20260424","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.4103\/1673-5374.389630","article-title":"Resident immune responses to spinal cord injury: role of astrocytes and microglia","volume":"19","author":"Brockie","year":"2024","journal-title":"Neural Regen Res"},{"key":"R6-20260424","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13024-023-00648-x","article-title":"Oleoylethanolamide facilitates PPAR\u03b1 and TFEB signaling and attenuates A\u03b2 pathology in a mouse model of Alzheimer\u2019s disease","volume":"18","author":"Comerota","year":"2023","journal-title":"Mol Neurodegener"},{"key":"R7-20260424","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-023-06502-w","article-title":"Specialized astrocytes mediate glutamatergic gliotransmission in the CNS","volume":"622","author":"de Ceglia","year":"2023","journal-title":"Nature"},{"key":"R8-20260424","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1016\/j.cell.2022.09.030","article-title":"SYK coordinates neuroprotective microglial responses in neurodegenerative disease","volume":"185","author":"Ennerfelt","year":"2022","journal-title":"Cell"},{"key":"R9-20260424","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat Neurosci"},{"key":"R10-20260424","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12974-020-01980-5","article-title":"Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer\u2019s disease models","volume":"18","author":"Fassler","year":"2021","journal-title":"J Neuroinflammation"},{"key":"R11-20260424","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s12974-022-02580-1","article-title":"Pathogenesis, therapeutic strategies and biomarker development based on \u201comics\u201d analysis related to microglia in Alzheimer\u2019s disease","volume":"19","author":"Gao","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R12-20260424","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41392-023-01588-0","article-title":"Microglia in neurodegenerative diseases: mechanism and potential therapeutic targets","volume":"8","author":"Gao","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"R13-20260424","doi-asserted-by":"crossref","first-page":"106227","DOI":"10.1016\/j.phrs.2022.106227","article-title":"Daphnetin ameliorates A\u03b2 pathogenesis via STAT3\/GFAP signaling in an APP\/PS1 double-transgenic mouse model of Alzheimer\u2019s disease","volume":"180","author":"Gao","year":"2022","journal-title":"Pharmacol Res"},{"key":"R14-20260424","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.2174\/1570159X20666220201094547","article-title":"Galectin-3 in microglia-mediated neuroinflammation: implications for central nervous system diseases","volume":"20","author":"Ge","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"R15-20260424","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.immuni.2021.12.001","article-title":"Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function","volume":"55","author":"He","year":"2022","journal-title":"Immunity"},{"key":"R16-20260424","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-022-02507-w","article-title":"Effect of rottlerin on astrocyte phenotype polarization after trimethyltin insult in the dentate gyrus of mice","volume":"19","author":"Hwang","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R17-20260424","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/s41467-021-27702-w","article-title":"Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and A\u00df pathology","volume":"13","author":"Jiwaji","year":"2022","journal-title":"Nat Commun"},{"key":"R18-20260424","doi-asserted-by":"crossref","first-page":"543","DOI":"10.4103\/1673-5374.320970","article-title":"Pathological mechanisms and therapeutic strategies for Alzheimer\u2019s disease","volume":"17","author":"Ju","year":"2022","journal-title":"Neural Regen Res"},{"key":"R19-20260424","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s12035-021-02611-7","article-title":"Implications of phosphoinositide 3-kinase-Akt (PI3K-Akt) pathway in the pathogenesis of Alzheimer\u2019s disease","volume":"59","author":"Kumar","year":"2022","journal-title":"Mol Neurobiol"},{"key":"R20-20260424","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1038\/s41586-020-03060-3","article-title":"Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis","volume":"590","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"R21-20260424","doi-asserted-by":"crossref","first-page":"867","DOI":"10.4103\/1673-5374.322463","article-title":"Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases","volume":"17","author":"Li","year":"2022","journal-title":"Neural Regen Res"},{"key":"R22-20260424","doi-asserted-by":"crossref","first-page":"114044","DOI":"10.1016\/j.ejmech.2021.114044","article-title":"Design, synthesis, and biological evaluation of carbamate derivatives of N-salicyloyl tryptamine as multifunctional agents for the treatment of Alzheimer\u2019s disease","volume":"229","author":"Liu","year":"2022","journal-title":"Eur J Med Chem"},{"key":"R23-20260424","doi-asserted-by":"crossref","first-page":"115120","DOI":"10.1016\/j.ejmech.2023.115120","article-title":"Novel neuroprotective pyromeconic acid derivatives with concurrent anti-A\u03b2 deposition, anti-inflammatory, and anti-oxidation properties for treatment of Alzheimer\u2019s disease","volume":"248","author":"Liu","year":"2023","journal-title":"Eur J Med Chem"},{"key":"R24-20260424","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"R25-20260424","doi-asserted-by":"crossref","first-page":"648636","DOI":"10.3389\/fphar.2021.648636","article-title":"PI3K\/AKT signal pathway: a target of natural products in the prevention and treatment of Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"12","author":"Long","year":"2021","journal-title":"Front Pharmacol"},{"key":"R26-20260424","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.4103\/1673-5374.391181","article-title":"Emerging role of galectin 3 in neuroinflammation and neurodegeneration","volume":"19","author":"Lozinski","year":"2024","journal-title":"Neural Regen Res"},{"key":"R28-20260424","first-page":"D845","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"R29-20260424","doi-asserted-by":"crossref","first-page":"111438","DOI":"10.1016\/j.mad.2021.111438","article-title":"TREM2, microglia, and Alzheimer\u2019s disease","volume":"195","author":"Qin","year":"2021","journal-title":"Mech Ageing Dev"},{"key":"R30-20260424","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"R31-20260424","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature19323","article-title":"The antibody aducanumab reduces A\u03b2 plaques in Alzheimer\u2019s disease","volume":"537","author":"Sevigny","year":"2016","journal-title":"Nature"},{"key":"R32-20260424","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"key":"R33-20260424","doi-asserted-by":"crossref","first-page":"3473","DOI":"10.1038\/s41467-019-11441-0","article-title":"Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington\u2019s disease","volume":"10","author":"Siew","year":"2019","journal-title":"Nat Commun"},{"key":"R34-20260424","doi-asserted-by":"crossref","first-page":"5815","DOI":"10.1007\/s12035-016-0129-3","article-title":"Neuroprotection through rapamycin-induced activation of autophagy and PI3K\/Akt1\/mTOR\/CREB signaling against amyloid-\u03b2-induced oxidative stress, synaptic\/neurotransmission dysfunction, and neurodegeneration in adult rats","volume":"54","author":"Singh","year":"2017","journal-title":"Mol Neurobiol"},{"key":"R35-20260424","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-021-02372-6","article-title":"Diverse human astrocyte and microglial transcriptional responses to Alzheimer\u2019s pathology","volume":"143","author":"Smith","year":"2022","journal-title":"Acta Neuropathol"},{"key":"R36-20260424","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.3390\/cells10113047","article-title":"Novel galectin-3 roles in neurogenesis, inflammation and neurological diseases","volume":"10","author":"Soares","year":"2021","journal-title":"Cells"},{"key":"R37-20260424","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12974-023-02752-7","article-title":"Astrocytes display ultrastructural alterations and heterogeneity in the hippocampus of aged APP-PS1 mice and human post-mortem brain samples","volume":"20","author":"St-Pierre","year":"2023","journal-title":"J Neuroinflammation"},{"key":"R38-20260424","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13578-021-00592-7","article-title":"Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer\u2019s disease","volume":"11","author":"Tan","year":"2021","journal-title":"Cell Biosci"},{"key":"R39-20260424","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/s41418-019-0348-z","article-title":"Galectin-3 promotes A\u03b2 oligomerization and A\u03b2 toxicity in a mouse model of Alzheimer\u2019s disease","volume":"27","author":"Tao","year":"2020","journal-title":"Cell Death Differ"},{"key":"R40-20260424","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1093\/nar\/gky092","article-title":"UniProt: the universal protein knowledgebase","volume":"46","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"R41-20260424","doi-asserted-by":"crossref","first-page":"101622","DOI":"10.1016\/j.arr.2022.101622","article-title":"Glial cells in Alzheimer\u2019s disease: from neuropathological changes to therapeutic implications","volume":"78","author":"Uddin","year":"2022","journal-title":"Ageing Res Rev"},{"key":"R42-20260424","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.4103\/1673-5374.389645","article-title":"p38-MAPK and CDK5, signaling pathways in neuroinflammation: a potential therapeutic intervention in Alzheimer\u2019s disease?","volume":"19","author":"Viorel","year":"2024","journal-title":"Neural Regen Res"},{"key":"R43-20260424","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4103\/2045-9912.385939","article-title":"The effects of nitric oxide in Alzheimer\u2019s disease","volume":"14","author":"Wang","year":"2024","journal-title":"Med Gas Res"},{"key":"R44-20260424","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12974-023-02753-6","article-title":"Exercise suppresses neuroinflammation for alleviating Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"R45-20260424","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-023-02747-4","article-title":"IL-1\u03b2 and TNF-\u03b1 play an important role in modulating the risk of periodontitis and Alzheimer\u2019s disease","volume":"20","author":"Wang","year":"2023","journal-title":"J Neuroinflammation"},{"key":"R46-20260424","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.bbi.2023.07.011","article-title":"Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer\u2019s disease model by restoring BDNF signaling","volume":"113","author":"Wang","year":"2023","journal-title":"Brain Behav Immun"},{"key":"R47-20260424","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS-STING pathway contributes to Alzheimer\u2019s pathogenesis in 5\u00d7FAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat Aging"},{"key":"R48-20260424","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1523\/JNEUROSCI.2312-22.2023","article-title":"Elevated galectin-3 is associated with aging, multiple sclerosis, and oxidized phosphatidylcholine-induced neurodegeneration","volume":"43","author":"Xue","year":"2023","journal-title":"J Neurosci"},{"key":"R49-20260424","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1021\/acs.jnatprod.2c00810","article-title":"Hyperhubeins A-I, bioactive sesquiterpenes with diverse skeletons from hypericum hubeiense","volume":"86","author":"Yan","year":"2023","journal-title":"J Nat Prod"},{"key":"R50-20260424","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13020-022-00634-3","article-title":"Salidroside attenuates neuronal ferroptosis by activating the Nrf2\/HO1 signaling pathway in A\u03b2(1-42)-induced Alzheimer\u2019s disease mice and glutamate-injured HT22 cells","volume":"17","author":"Yang","year":"2022","journal-title":"Chin Med"},{"key":"R51-20260424","doi-asserted-by":"crossref","first-page":"153571","DOI":"10.1016\/j.phymed.2021.153571","article-title":"The piperine derivative HJ105 inhibits A\u03b2(1-42)-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis","volume":"87","author":"Yang","year":"2021","journal-title":"Phytomedicine"},{"key":"R52-20260424","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1002\/glia.22886","article-title":"Dual pathways mediate \u03b2-amyloid stimulated glutathione release from astrocytes","volume":"63","author":"Ye","year":"2015","journal-title":"Glia"},{"key":"R53-20260424","doi-asserted-by":"crossref","first-page":"106099","DOI":"10.1016\/j.phrs.2022.106099","article-title":"Targeting Akt\/CREB\/BDNF signaling pathway by ginsenosides in neurodegenerative diseases: A mechanistic approach","volume":"177","author":"Zarneshan","year":"2022","journal-title":"Pharmacol Res"},{"key":"R54-20260424","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.4103\/1673-5374.389745","article-title":"Interplay between microglia and environmental risk factors in Alzheimer\u2019s disease","volume":"19","author":"Zhang","year":"2024","journal-title":"Neural Regen Res"},{"key":"R55-20260424","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.4103\/1673-5374.373680","article-title":"The role of natural flavonoids on neuroinflammation as a therapeutic target for Alzheimer\u2019s disease: a narrative review","volume":"18","author":"Zhang","year":"2023","journal-title":"Neural Regen Res"},{"key":"R56-20260424","doi-asserted-by":"crossref","first-page":"119961","DOI":"10.1016\/j.carbpol.2022.119961","article-title":"Advances in polysaccharides of natural source of the anti-Alzheimer\u2019s disease effect and mechanism","volume":"296","author":"Zhang","year":"2022","journal-title":"Carbohydr Polym"},{"key":"R57-20260424","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41593-023-01352-1","article-title":"\u03b2(2)-Microglobulin coaggregates with A\u03b2 and contributes to amyloid pathology and cognitive deficits in Alzheimer\u2019s disease model mice","volume":"26","author":"Zhao","year":"2023","journal-title":"Nat Neurosci"},{"key":"R58-20260424","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1016\/j.immuni.2023.06.016","article-title":"TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration","volume":"56","author":"Zhong","year":"2023","journal-title":"Immunity"},{"key":"R59-20260424","doi-asserted-by":"crossref","first-page":"6233","DOI":"10.1038\/s41467-022-33932-3","article-title":"Microglial debris is cleared by astrocytes via C4b-facilitated phagocytosis and degraded via RUBICON-dependent noncanonical autophagy in mice","volume":"13","author":"Zhou","year":"2022","journal-title":"Nat Commun"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-23-01890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:42:36Z","timestamp":1787067756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-23-01890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,10]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-23-01890","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,10]]},"assertion":[{"value":"2023-11-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}