{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T15:34:15Z","timestamp":1793979255500,"version":"4.8.0"},"reference-count":112,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202504000-00027\/figure1\/v\/2026-05-07T083851Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Cardiac arrest can lead to severe neurological impairment as a result of inflammation, mitochondrial dysfunction, and post-cardiopulmonary resuscitation neurological damage. Hypoxic preconditioning has been shown to improve migration and survival of bone marrow\u2013derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest, but the specific mechanisms by which hypoxia-preconditioned bone marrow\u2013derived mesenchymal stem cells protect against brain injury after cardiac arrest are unknown. To this end, we established an\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    co-culture model of bone marrow\u2013derived mesenchymal stem cells and oxygen\u2013glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis, possibly through inhibition of the MAPK and nuclear factor \u03baB pathways. Subsequently, we transplanted hypoxia-preconditioned bone marrow\u2013derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by asphyxia. The results showed that hypoxia-preconditioned bone marrow\u2013derived mesenchymal stem cells significantly reduced cardiac arrest\u2013induced neuronal pyroptosis, oxidative stress, and mitochondrial damage, whereas knockdown of the liver isoform of phosphofructokinase in bone marrow\u2013derived mesenchymal stem cells inhibited these effects. To conclude, hypoxia-preconditioned bone marrow\u2013derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest, and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01922","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T02:04:17Z","timestamp":1717725857000},"page":"1103-1123","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Hypoxia-preconditioned bone marrow\u2013derived mesenchymal stem cells protect neurons from cardiac arrest\u2013induced 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Provincial Key Laboratory of Emergency Medicine, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Department of Emergency, Fujian Provincial Hospital, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Emergency Medicine, Fuzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Shengli Clinical Medical College of Fujian Medical University, Fujian Medical University, Fuzhou, Fujian Province, China"},{"name":"Department of Emergency, Fujian Provincial Hospital, Fuzhou, Fujian Province, China"},{"name":"Fujian Provincial Key Laboratory of Emergency Medicine, Fuzhou, Fujian Province, 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