{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:51:32Z","timestamp":1789044692683,"version":"build-2803163510"},"reference-count":68,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T00:00:00Z","timestamp":1719360000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202510000-00028\/figure1\/v\/2026-04-25T153616Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>Alzheimer\u2019s disease not only affects the brain, but also induces metabolic dysfunction in peripheral organs and alters the gut microbiota. The aim of this study was to investigate systemic changes that occur in Alzheimer\u2019s disease, in particular the association between changes in peripheral organ metabolism, changes in gut microbial composition, and Alzheimer\u2019s disease development. To do this, we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1 (APP\/PS1) transgenic and control mice at 3, 6, 9, and 12 months of age. Twelve-month-old APP\/PS1 mice exhibited cognitive impairment, Alzheimer\u2019s disease\u2013related brain changes, distinctive metabolic disturbances in peripheral organs and fecal samples (as detected by untargeted metabolomics sequencing), and substantial changes in gut microbial composition compared with younger APP\/PS1 mice. Notably, a strong correlation emerged between the gut microbiota and kidney metabolism in APP\/PS1 mice. These findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer\u2019s disease development, indicating potential new directions for therapeutic strategies.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01979","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T02:04:58Z","timestamp":1732845898000},"page":"2982-2997","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"20","author":[{"given":"Hongli","family":"Li","sequence":"first","affiliation":[{"name":"Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan Province, China"},{"name":"National Clinical Research Center for 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