{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:56:55Z","timestamp":1791475015145,"version":"4.3.4"},"reference-count":65,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202510000-00027\/figure1\/v\/2026-04-25T153616Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer\u2019s disease. Adult hippocampal neurogenesis is reduced in patients with Alzheimer\u2019s disease. Exercise stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer\u2019s disease. However, the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer\u2019s disease are poorly understood. Recently, regulator of G protein signaling 6 (RGS6) was identified as the mediator of voluntary running\u2013induced adult hippocampal neurogenesis in mice. Here, we generated novel RGS6\n                    <jats:sup>fl\/fl<\/jats:sup>\n                    ; APP\n                    <jats:sub>SWE<\/jats:sub>\n                    mice and used retroviral approaches to examine the impact of RGS6 deletion from dentate gyrus neuronal progenitor cells on voluntary running\u2013induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer\u2019s disease mouse model. We found that voluntary running in APP\n                    <jats:sub>SWE<\/jats:sub>\n                    mice restored their hippocampal cognitive impairments to that of control mice. This cognitive rescue was abolished by RGS6 deletion in dentate gyrus neuronal progenitor cells, which also abolished running-mediated increases in adult hippocampal neurogenesis. Adult hippocampal neurogenesis was reduced in sedentary APP\n                    <jats:sub>SWE<\/jats:sub>\n                    mice\n                    <jats:italic toggle=\"yes\">versus<\/jats:italic>\n                    control mice, with basal adult hippocampal neurogenesis reduced by RGS6 deletion in dentate gyrus neural precursor cells. RGS6 was expressed in neurons within the dentate gyrus of patients with Alzheimer\u2019s disease with significant loss of these RGS6-expressing neurons. Thus, RGS6 mediated voluntary running\u2013induced rescue of impaired cognition and adult hippocampal neurogenesis in APP\n                    <jats:sub>SWE<\/jats:sub>\n                    mice, identifying RGS6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer\u2019s disease.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-23-01993","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T07:08:31Z","timestamp":1725865711000},"page":"2969-2981","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis, learning, and memory in a mouse model of Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"20","author":[{"given":"Mackenzie M.","family":"Spicer","sequence":"first","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Interdisciplinary Graduate Program in Molecular Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison N.","family":"DeVore","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisol","family":"Lauffer","sequence":"additional","affiliation":[{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Neural Circuits and Behavior Core, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilufer S.","family":"Atasoy","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Atasoy","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-4836","authenticated-orcid":false,"given":"Rory A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, IA, USA"},{"name":"Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"R1-20260425","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0379-21.2021","article-title":"Protein profiling of RGS6, a pleiotropic gene implicated in numerous neuropsychiatric disorders, reveals multi-isoformic expression and a novel brain-specific isoform","volume":"9","author":"Ahlers-Dannen","year":"2022","journal-title":"eNeuro"},{"key":"R2-20260425","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s10038-024-01220-1","article-title":"A splice acceptor variant in RGS6 associated with intellectual disability, microcephaly, and cataracts disproportionately promotes expression of a subset of RGS6 isoforms","volume":"69","author":"Ahlers-Dannen","year":"2024","journal-title":"J Hum Genet"},{"key":"R3-20260425","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/ar.1091450409","article-title":"Autoradiographic 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