{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:37:38Z","timestamp":1786649858275,"version":"build-2736575974"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202601000-00037\/figure1\/v\/2026-04-22T161640Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Neuroserpin, a secreted protein that belongs to the serpin superfamily of serine protease inhibitors, is highly expressed in the central nervous system and plays multiple roles in brain development and pathology. As a natural inhibitor of recombinant tissue plasminogen activator, neuroserpin inhibits the increased activity of tissue plasminogen activator in ischemic conditions and extends the therapeutic windows of tissue plasminogen activator for brain ischemia. However, the neuroprotective mechanism of neuroserpin against ischemic stroke remains unclear. In this study, we used a mouse model of middle cerebral artery occlusion and oxygen-glucose deprivation\/reperfusion-injured cortical neurons as\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    ischemia-reperfusion models, respectively. The models were used to investigate the neuroprotective effects of neuroserpin. Our findings revealed that endoplasmic reticulum stress was promptly triggered following ischemia, initially manifesting as the acute activation of endoplasmic reticulum stress transmembrane sensors and the suppression of protein synthesis, which was followed by a later apoptotic response. Notably, ischemic stroke markedly downregulated the expression of neuroserpin in cortical neurons. Exogenous neuroserpin reversed the activation of multiple endoplasmic reticulum stress signaling molecules, the reduction in protein synthesis, and the upregulation of apoptotic transcription factors. This led to a reduction in neuronal death induced by oxygen\/glucose deprivation and reperfusion, as well as decreased cerebral infarction and neurological dysfunction in mice with middle cerebral artery occlusion. However, the neuroprotective effects of neuroserpin were markedly inhibited by endoplasmic reticulum stress activators thapsigargin and tunicamycin. Our findings demonstrate that neuroserpin exerts neuroprotective effects on ischemic stroke by suppressing endoplasmic reticulum stress.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-00044","type":"journal-article","created":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T13:19:16Z","timestamp":1743427156000},"page":"333-345","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["Neuroserpin alleviates cerebral ischemia-reperfusion injury by suppressing ischemia-induced endoplasmic reticulum stress"],"prefix":"10.4103","volume":"21","author":[{"given":"Yumei","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghua","family":"Zhang","sequence":"additional","affiliation":[{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoyun","family":"Shi","sequence":"additional","affiliation":[{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyun","family":"Zhong","sequence":"additional","affiliation":[{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Huang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Peng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen Key Laboratory for Neuronal Structural Biology, Biomedical Research Institute; Institute of Geriatric Medicine, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Istv\u00e1n","family":"Adorj\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumi","family":"Fukuzaki","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of California, San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Kawashita","sequence":"additional","affiliation":[{"name":"Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8518-5627","authenticated-orcid":false,"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-5473-2631","authenticated-orcid":false,"given":"Xiaoshen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"School of Nursing, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6852-6004","authenticated-orcid":false,"given":"Zolt\u00e1n","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8695-3432","authenticated-orcid":false,"given":"Lei","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research; Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/joa.12931","article-title":"Neuroserpin expression during human brain development and in adult brain revealed by immunohistochemistry and single cell RNA sequencing","volume":"235","author":"Adorjan","year":"2019","journal-title":"J Anat"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/febs.14608","article-title":"Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"e149","DOI":"10.1038\/cddis.2011.31","article-title":"Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12","volume":"2","author":"Badiola","year":"2011","journal-title":"Cell Death Dis"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"46852","DOI":"10.1074\/jbc.M207740200","article-title":"Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro","volume":"277","author":"Barker-Carlson","year":"2002","journal-title":"J Biol Chem"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1126\/science.1101902","article-title":"A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress","volume":"307","author":"Boyce","year":"2005","journal-title":"Science"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"e22570","DOI":"10.1002\/jbt.22570","article-title":"Neuroserpin extends the time window of tPA thrombolysis in a rat model of middle cerebral artery occlusion","volume":"34","author":"Cai","year":"2020","journal-title":"J Biochem Mol Toxicol"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(19)31053-0","article-title":"Extending thrombolysis to 4\u00b75\u20139 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data","volume":"394","author":"Campbell","year":"2019","journal-title":"Lancet"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"603","DOI":"10.4103\/1673-5374.350204","article-title":"\u03b22\u2013Microglobulin exacerbates neuroinflammation, brain damage, and cognitive impairment after stroke in rats","volume":"18","author":"Chen","year":"2023","journal-title":"Neural Regen Res"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12031-016-0807-7","article-title":"Neuroserpin attenuates H(2)O(2)-induced oxidative stress in hippocampal neurons via AKT and BCL-2 signaling pathways","volume":"61","author":"Cheng","year":"2017","journal-title":"J Mol Neurosci"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1006\/mcne.2001.1028","article-title":"Neuroserpin, a neuroprotective factor in focal ischemic stroke","volume":"18","author":"Cinelli","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2174\/1570159X18666201008113052","article-title":"The neuroprotective role of neuroserpin in ischemic and hemorrhagic stroke","volume":"19","author":"Ding","year":"2021","journal-title":"Curr Neuropharmacol"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"R14-20260422","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/aps.2013.34","article-title":"The endoplasmic reticulum stress inhibitor salubrinal inhibits the activation of autophagy and neuroprotection induced by brain ischemic preconditioning","volume":"34","author":"Gao","year":"2013","journal-title":"Acta Pharmacol Sin"},{"key":"R15-20260422","doi-asserted-by":"crossref","first-page":"e63118","DOI":"10.1371\/journal.pone.0063118","article-title":"Deficiency in serine protease inhibitor neuroserpin exacerbates ischemic brain injury by increased postischemic inflammation","volume":"8","author":"Gelderblom","year":"2013","journal-title":"PLoS One"},{"key":"R16-20260422","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuron.2015.05.041","article-title":"Novel stroke therapeutics: unraveling stroke pathophysiology and its impact on clinical treatments","volume":"87","author":"George","year":"2015","journal-title":"Neuron"},{"key":"R17-20260422","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/s00018-022-04185-6","article-title":"Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell-cell interactions in the pathophysiology of neurological disease","volume":"79","author":"Godinez","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"e3080","DOI":"10.1038\/cddis.2017.465","article-title":"RTN1-C mediates cerebral ischemia\/reperfusion injury via ER stress and mitochondria-associated apoptosis pathways","volume":"8","author":"Gong","year":"2017","journal-title":"Cell Death Dis"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.bbrc.2012.08.068","article-title":"Endoplasmic reticulum (ER) stress inhibitor salubrinal protects against ceramide-induced SH-SY5Y cell death","volume":"427","author":"Gong","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"R20-20260422","doi-asserted-by":"crossref","first-page":"e0130440","DOI":"10.1371\/journal.pone.0130440","article-title":"Retina is protected by neuroserpin from ischemic\/reperfusion-induced injury independent of tissue-type plasminogen activator","volume":"10","author":"Gu","year":"2015","journal-title":"PLoS One"},{"key":"R21-20260422","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/s41380-019-0472-7","article-title":"Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function","volume":"26","author":"Guo","year":"2021","journal-title":"Mol Psychiatry"},{"key":"R22-20260422","doi-asserted-by":"crossref","first-page":"632662","DOI":"10.3389\/fphar.2021.632662","article-title":"Deficiency in Neuroserpin Exacerbates CoCl(2) Induced hypoxic injury in the zebrafish model by increased oxidative stress","volume":"12","author":"Han","year":"2021","journal-title":"Front Pharmacol"},{"key":"R23-20260422","doi-asserted-by":"crossref","first-page":"704334","DOI":"10.3389\/fncel.2021.704334","article-title":"Mechanism of endoplasmic reticulum stress in cerebral ischemia","volume":"15","author":"Han","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"R24-20260422","doi-asserted-by":"crossref","first-page":"7356266","DOI":"10.1155\/2021\/7356266","article-title":"Deficiency of ROS-activated TRPM2 channel protects neurons from cerebral ischemia-reperfusion injury through upregulating autophagy","volume":"2021","author":"Hu","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"R25-20260422","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"R26-20260422","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s00702-014-1208-0","article-title":"Salubrinal, ER stress inhibitor, attenuates kainic acid-induced hippocampal cell death","volume":"121","author":"Kim","year":"2014","journal-title":"J Neural Transm (Vienna)"},{"key":"R27-20260422","doi-asserted-by":"crossref","first-page":"8984","DOI":"10.1523\/JNEUROSCI.17-23-08984.1997","article-title":"Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse","volume":"17","author":"Krueger","year":"1997","journal-title":"J Neurosci"},{"key":"R28-20260422","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.mcn.2005.09.005","article-title":"The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo","volume":"30","author":"Lebeurrier","year":"2005","journal-title":"Mol Cell Neurosci"},{"key":"R29-20260422","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1172\/JCI11003","article-title":"Brain tissue responses to ischemia","volume":"106","author":"Lee","year":"2000","journal-title":"J Clin Invest"},{"key":"R30-20260422","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.semcdb.2016.09.007","article-title":"Physiological and pathological functions of neuroserpin: Regulation of cellular responses through multiple mechanisms","volume":"62","author":"Lee","year":"2017","journal-title":"Semin Cell Dev Biol"},{"key":"R31-20260422","doi-asserted-by":"crossref","first-page":"611","DOI":"10.4103\/1673-5374.380870","article-title":"Ferroptosis and endoplasmic reticulum stress in ischemic stroke","volume":"19","author":"Li","year":"2024","journal-title":"Neural Regen Res"},{"key":"R32-20260422","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fphar.2018.00290","article-title":"A bivalent securinine compound SN3-L6 induces neuronal differentiation via translational upregulation of neurogenic transcription factors","volume":"9","author":"Liao","year":"2018","journal-title":"Front Pharmacol"},{"key":"R33-20260422","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.3390\/molecules28052370","article-title":"The protective effect of (-)-tetrahydroalstonine against OGD\/R-induced neuronal injury via autophagy regulation","volume":"28","author":"Liao","year":"2023","journal-title":"Molecules"},{"key":"R34-20260422","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.4103\/1673-5374.369114","article-title":"Exosomes from bone marrow mesenchymal stem cells are a potential treatment for ischemic stroke","volume":"18","author":"Liu","year":"2023","journal-title":"Neural Regen Res"},{"key":"R35-20260422","article-title":"Potential role of endoplasmic reticulum stress in modulating protein homeostasis in oligodendrocytes to improve white matter injury in preterm infants","author":"Liu","year":"2024","journal-title":"Mol Neurobiol"},{"key":"R36-20260422","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"R37-20260422","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"R38-20260422","doi-asserted-by":"crossref","first-page":"760","DOI":"10.4103\/1673-5374.353480","article-title":"Melatonin, tunneling nanotubes, mesenchymal cells, and tissue regeneration","volume":"18","author":"Luchetti","year":"2023","journal-title":"Neural Regen Res"},{"key":"R39-20260422","doi-asserted-by":"crossref","first-page":"114524","DOI":"10.1016\/j.expneurol.2023.114524","article-title":"Phenothiazines reduced autophagy in ischemic stroke through endoplasmic reticulum (ER) stress-associated PERK-eIF2\u03b1 pathway","volume":"369","author":"Lv","year":"2023","journal-title":"Exp Neurol"},{"key":"R40-20260422","first-page":"146","article-title":"Tissue plasminogen activator-independent roles of neuroserpin in the central nervous system","volume":"7","author":"Ma","year":"2012","journal-title":"Neural Regen Res"},{"key":"R41-20260422","doi-asserted-by":"crossref","first-page":"e54543","DOI":"10.15252\/embr.202154543","article-title":"eEF2 in the prefrontal cortex promotes excitatory synaptic transmission and social novelty behavior","volume":"23","author":"Ma","year":"2022","journal-title":"EMBO Rep"},{"key":"R42-20260422","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0165-6147(90)90254-6","article-title":"Excitatory amino acid receptors, second messengers and regulation of intracellular Ca2+ in mammalian neurons","volume":"11","author":"Mayer","year":"1990","journal-title":"Trends Pharmacol Sci"},{"key":"R43-20260422","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncel.2017.00078","article-title":"Neonatal hypoxia ischaemia: mechanisms, models, and therapeutic challenges","volume":"11","author":"Millar","year":"2017","journal-title":"Front Cell Neurosci"},{"key":"R44-20260422","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12640-009-9110-5","article-title":"Endoplasmic reticulum stress plays critical role in brain damage after cerebral ischemia\/reperfusion in rats","volume":"17","author":"Nakka","year":"2010","journal-title":"Neurotox Res"},{"key":"R45-20260422","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1056\/NEJM199512143332401","article-title":"Tissue plasminogen activator for acute ischemic stroke","volume":"333","year":"1995","journal-title":"N Engl J Med"},{"key":"R46-20260422","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s11655-021-3454-y","article-title":"Total saponins of panax notoginseng activate Akt\/mTOR pathway and exhibit neuroprotection in vitro and in vivo against ischemic damage","volume":"28","author":"Pan","year":"2022","journal-title":"Chin J Integr Med"},{"key":"R47-20260422","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"R48-20260422","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1186\/s12974-022-02599-4","article-title":"Injection of amyloid-\u03b2 to lateral ventricle induces gut microbiota dysbiosis in association with inhibition of cholinergic anti-inflammatory pathways in Alzheimer\u2019s disease","volume":"19","author":"Qian","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R49-20260422","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.neuint.2010.12.006","article-title":"Neuroprotective effect of neuroserpin in rat primary cortical cultures after oxygen and glucose deprivation and tPA","volume":"58","author":"Rodr\u00edguez-Gonz\u00e1lez","year":"2011","journal-title":"Neurochem Int"},{"key":"R50-20260422","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/1479-5876-9-58","article-title":"Association between neuroserpin and molecular markers of brain damage in patients with acute ischemic stroke","volume":"9","author":"Rodr\u00edguez-Gonz\u00e1lez","year":"2011","journal-title":"J Transl Med"},{"key":"R51-20260422","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1160\/TH10-09-0621","article-title":"The natural tissue plasminogen activator inhibitor neuroserpin and acute ischaemic stroke outcome","volume":"105","author":"Rodr\u00edguez-Gonz\u00e1lez","year":"2011","journal-title":"Thromb Haemost"},{"key":"R52-20260422","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1474-4422(12)70238-7","article-title":"Endoplasmic reticulum dysfunction in neurological disease","volume":"12","author":"Roussel","year":"2013","journal-title":"Lancet Neurol"},{"key":"R53-20260422","doi-asserted-by":"crossref","first-page":"769","DOI":"10.4103\/1673-5374.353483","article-title":"Roles of constitutively secreted extracellular chaperones in neuronal cell repair and regeneration","volume":"18","author":"Satapathy","year":"2023","journal-title":"Neural Regen Res"},{"key":"R54-20260422","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"R55-20260422","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neulet.2016.10.038","article-title":"Effects of 4-phenyl butyric acid on high glucose-induced alterations in dorsal root ganglion neurons","volume":"635","author":"Sharma","year":"2016","journal-title":"Neurosci Lett"},{"key":"R56-20260422","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/jphp.13096","article-title":"A natural diarylheptanoid protects cortical neurons against oxygen-glucose deprivation-induced autophagy and apoptosis","volume":"71","author":"Shi","year":"2019","journal-title":"J Pharm Pharmacol"},{"key":"R57-20260422","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1523\/JNEUROSCI.4289-06.2007","article-title":"Endoplasmic reticulum stress inhibition protects against excitotoxic neuronal injury in the rat brain","volume":"27","author":"Sokka","year":"2007","journal-title":"J Neurosci"},{"key":"R58-20260422","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2011.07.004","article-title":"Sodium phenylbutyrate ameliorates focal cerebral ischemic\/reperfusion injury associated with comorbid type 2 diabetes by reducing endoplasmic reticulum stress and DNA fragmentation","volume":"225","author":"Srinivasan","year":"2011","journal-title":"Behav Brain Res"},{"key":"R59-20260422","doi-asserted-by":"crossref","first-page":"642","DOI":"10.4103\/1673-5374.380904","article-title":"Treatment with \u03b2-sitosterol ameliorates the effects of cerebral ischemia\/reperfusion injury by suppressing cholesterol overload, endoplasmic reticulum stress, and apoptosis","volume":"19","author":"Tang","year":"2024","journal-title":"Neural Regen Res"},{"key":"R60-20260422","doi-asserted-by":"crossref","first-page":"637","DOI":"10.3389\/fnins.2019.00637","article-title":"Proteostasis during cerebral ischemia","volume":"13","author":"Thiebaut","year":"2019","journal-title":"Front Neurosci"},{"key":"R61-20260422","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"R62-20260422","doi-asserted-by":"crossref","first-page":"864426","DOI":"10.3389\/fncel.2022.864426","article-title":"Endoplasmic reticulum stress and the unfolded protein response in cerebral ischemia\/reperfusion injury","volume":"16","author":"Wang","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"R63-20260422","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.2353\/ajpath.2010.100466","article-title":"Neuroserpin protects neurons from ischemia-induced plasmin-mediated cell death independently of tissue-type plasminogen activator inhibition","volume":"177","author":"Wu","year":"2010","journal-title":"Am J Pathol"},{"key":"R64-20260422","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Camb)"},{"key":"R65-20260422","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1080\/01616412.2017.1357780","article-title":"Effects of neuroserpin on clinical outcomes and inflammatory markers in Chinese patients with acute ischemic stroke","volume":"39","author":"Wu","year":"2017","journal-title":"Neurol Res"},{"key":"R66-20260422","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.3390\/ijms19082291","article-title":"Induction of liver steatosis in BAP31-deficient mice burdened with tunicamycin-induced endoplasmic reticulum stress","volume":"19","author":"Wu","year":"2018","journal-title":"Int J Mol Sci"},{"key":"R67-20260422","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuint.2014.02.001","article-title":"Endoplasmic reticulum stress in cerebral ischemia","volume":"68","author":"Xin","year":"2014","journal-title":"Neurochem Int"},{"key":"R68-20260422","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1159\/000443089","article-title":"Neuroserpin protects rat neurons and microglia-mediated inflammatory response against oxygen-glucose deprivation- and reoxygenation treatments in an in vitro study","volume":"38","author":"Yang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"R69-20260422","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1182\/blood.V96.2.569.014k35_569_576","article-title":"Neuroserpin reduces cerebral infarct volume and protects neurons from ischemia-induced apoptosis","volume":"96","author":"Yepes","year":"2000","journal-title":"Blood"},{"key":"R70-20260422","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/01.CIR.0000023942.10849.41","article-title":"Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke","volume":"106","author":"Zhang","year":"2002","journal-title":"Circulation"},{"key":"R71-20260422","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/s41419-021-03541-x","article-title":"MiR-127-3p targeting CISD1 regulates autophagy in hypoxic-ischemic cortex","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis"},{"key":"R72-20260422","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1080\/13880209.2022.2032207","article-title":"Wasp venom from Vespa magnifica acts as a neuroprotective agent to alleviate neuronal damage after stroke in rats","volume":"60","author":"Zhao","year":"2022","journal-title":"Pharm Biol"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:59:12Z","timestamp":1786647552000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":72,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-00044","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"2024-01-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}