{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T23:17:12Z","timestamp":1793229432052,"version":"4.5.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.4103\/nrr.nrr-d-24-00133","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T03:00:59Z","timestamp":1716433259000},"page":"815-816","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Monogenic gene therapy for glaucoma and optic nerve injury"],"prefix":"10.4103","volume":"20","author":[{"given":"Chikako","family":"Harada","sequence":"first","affiliation":[{"name":"Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Guo","sequence":"additional","affiliation":[{"name":"Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6167-0997","authenticated-orcid":false,"given":"Takayuki","family":"Harada","sequence":"additional","affiliation":[{"name":"Visual Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"R1-20260505","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1038\/s41586-023-06935-3","article-title":"A molecular switch for neuroprotective astrocyte reactivity","volume":"626","author":"Cameron","year":"2024","journal-title":"Nature"},{"key":"R2-20260505","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/bjophthalmol-2018-312724","article-title":"Recent advances in genetically modified animal models of glaucoma and their roles in drug repositioning","volume":"103","author":"Harada","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"R3-20260505","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1172\/JCI30178","article-title":"The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma","volume":"117","author":"Harada","year":"2007","journal-title":"J Clin Invest"},{"key":"R4-20260505","doi-asserted-by":"crossref","first-page":"eabd2590","DOI":"10.1126\/sciadv.abd2590","article-title":"Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery","volume":"7","author":"Khatib","year":"2021","journal-title":"Sci Adv"},{"key":"R5-20260505","doi-asserted-by":"crossref","first-page":"137124","DOI":"10.1016\/j.neulet.2023.137124","article-title":"Effects of constitutively active K-Ras on axon regeneration after optic nerve injury","volume":"799","author":"Kiyota","year":"2023","journal-title":"Neurosci Lett"},{"key":"R6-20260505","doi-asserted-by":"crossref","first-page":"875662","DOI":"10.3389\/fphar.2022.875662","article-title":"Brain-derived neurotrophic factor-mediated neuroprotection in glaucoma: A review of current state of the art","volume":"13","author":"Lambuk","year":"2022","journal-title":"Front Pharmacol"},{"key":"R7-20260505","doi-asserted-by":"crossref","first-page":"7586","DOI":"10.1073\/pnas.0914514107","article-title":"Dock3 induces axonal outgrowth by stimulating membrane recruitment of the WAVE complex","volume":"107","author":"Namekata","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R8-20260505","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41420-023-01460-8","article-title":"Neuroprotection and axon regeneration by novel low-molecular-weight compounds through the modification of DOCK3 conformation","volume":"9","author":"Namekata","year":"2023","journal-title":"Cell Death Discov"},{"key":"R9-20260505","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.ymthe.2022.11.018","article-title":"Vision protection and robust axon regeneration in glaucoma models by membrane-associated Trk receptors","volume":"31","author":"Nishijima","year":"2023","journal-title":"Mol Ther"},{"key":"R10-20260505","doi-asserted-by":"crossref","first-page":"eabq1081","DOI":"10.1126\/sciadv.abq1081","article-title":"Astrocytic dysfunction induced by ABCA1 deficiency causes optic neuropathy","volume":"8","author":"Shinozaki","year":"2022","journal-title":"Sci Adv"},{"key":"R11-20260505","doi-asserted-by":"crossref","first-page":"1310226","DOI":"10.3389\/fopht.2023.1310226","article-title":"Glial cells as a promising therapeutic target of glaucoma: beyond the IOP","volume":"3","author":"Shinozaki","year":"2024","journal-title":"Front Ophthalmol"},{"key":"R12-20260505","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nature10594","article-title":"Sustained axon regeneration induced by co-deletion of PTEN and SOCS3","volume":"480","author":"Sun","year":"2011","journal-title":"Nature"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00133","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:35:39Z","timestamp":1787769339000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-00133","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]},"assertion":[{"value":"2024-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-09","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}