{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:37:56Z","timestamp":1789871876418,"version":"4.0.1"},"reference-count":115,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T00:00:00Z","timestamp":1727136000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:p>Alzheimer\u2019s disease is a common neurodegenerative disorder defined by decreased reasoning abilities, memory loss, and cognitive deterioration. The presence of the blood\u2013brain barrier presents a major obstacle to the development of effective drug therapies for Alzheimer\u2019s disease. The use of ultrasound as a novel physical modulation approach has garnered widespread attention in recent years. As a safe and feasible therapeutic and drug-delivery method, ultrasound has shown promise in improving cognitive deficits. This article provides a summary of the application of ultrasound technology for treating Alzheimer\u2019s disease over the past 5 years, including standalone ultrasound treatment, ultrasound combined with microbubbles or drug therapy, and magnetic resonance imaging\u2013guided focused ultrasound therapy. Emphasis is placed on the benefits of introducing these treatment methods and their potential mechanisms. We found that several ultrasound methods can open the blood\u2013brain barrier and effectively alleviate amyloid-\u03b2 plaque deposition. We believe that ultrasound is an effective therapy for Alzheimer\u2019s disease, and this review provides a theoretical basis for future ultrasound treatment methods.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-00539","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T04:04:16Z","timestamp":1727150656000},"page":"2823-2837","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Progress of research in the application of ultrasound technology for the treatment of Alzheimer\u2019s disease"],"prefix":"10.4103","volume":"20","author":[{"given":"Qiuquan","family":"Cai","sequence":"first","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianghui","family":"Meng","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meina","family":"Quan","sequence":"additional","affiliation":[{"name":"Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"},{"name":"Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory, Tianjin University, Tianjin, China"},{"name":"Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Ren","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"},{"name":"Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory, Tianjin University, Tianjin, China"},{"name":"Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5439-7136","authenticated-orcid":false,"given":"Jiajia","family":"Yang","sequence":"additional","affiliation":[{"name":"Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China"},{"name":"Brain-Computer Interaction and Human-Machine Fusion Haihe Laboratory, Tianjin University, Tianjin, China"},{"name":"Tianjin Key Laboratory of Brain Science and Neural Engineering, Tianjin University, Tianjin, 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