{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:32:07Z","timestamp":1787841127532,"version":"build-2784847793"},"reference-count":220,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T00:00:00Z","timestamp":1733529600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Effective treatment methods for stroke, a common cerebrovascular disease with a high mortality rate, are still being sought. Exosome therapy, a form of acellular therapy, has demonstrated promising efficacy in various diseases in animal models; however, there is currently insufficient evidence to guide the clinical application of exosome in patients with stroke. This article reviews the progress of exosome applications in stroke treatment. It aims to elucidate the significant potential value of exosomes in stroke therapy and provide a reference for their clinical translation. At present, many studies on exosome-based therapies for stroke are actively underway. Regarding preclinical research, exosomes, as bioactive substances with diverse sources, currently favor stem cells as their origin. Due to their high plasticity, exosomes can be effectively modified through various physical, chemical, and genetic engineering methods to enhance their efficacy. In animal models of stroke, exosome therapy can reduce neuroinflammatory responses, alleviate oxidative stress damage, and inhibit programmed cell death. Additionally, exosomes can promote angiogenesis, repair and regenerate damaged white matter fiber bundles, and facilitate the migration and differentiation of neural stem cells, aiding the repair process. We also summarize new directions for the application of exosomes, specifically the exosome intervention through the ventricular\u2013meningeal lymphatic system. The review findings suggest that the treatment paradigm for stroke is poised for transformation.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-00665","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:04:22Z","timestamp":1734001462000},"page":"6-22","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Exosomes in stroke management: A promising paradigm shift in stroke therapy"],"prefix":"10.4103","volume":"21","author":[{"given":"Bo","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, The First Hospital Affiliated to Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinzhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, The First Hospital Affiliated to Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1861-6383","authenticated-orcid":false,"given":"Wenyan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital Affiliated to Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8404-4937","authenticated-orcid":false,"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Hospital Affiliated to Army Medical University, Chongqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,7]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.3390\/cells10092319","article-title":"Induced pluripotent stem cells (iPSCs)-roles in regenerative therapies, disease modelling and drug screening","volume":"10","author":"Aboul-Soudm","year":"2021","journal-title":"Cells"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3171\/2023.2.JNS222807","article-title":"Stroke management and outcomes in low-income and lower-middle-income countries: a meta-analysis of 8535 patients","volume":"139","author":"Aguirre","year":"2023","journal-title":"J Neurosurg"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/sctm.20-0301","article-title":"Brain-derived neurotropic factor mediates neuroprotection of mesenchymal stem cell-derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats","volume":"10","author":"Ahn","year":"2021","journal-title":"Stem Cells Transl Med"},{"key":"R4-20260422","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0395-17.2018","article-title":"Post-stroke intranasal (+)-naloxone delivery reduces microglial activation and improves behavioral recovery from ischemic injury","author":"Anttila","year":"2018","journal-title":"eNeuro"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.tcb.2023.06.006","article-title":"The ins-and-outs of exosome biogenesis, secretion, and internalization","volume":"34","author":"Arya","year":"2024","journal-title":"Trends Cell Biol"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"117","DOI":"10.12793\/tcp.2017.25.3.117","article-title":"Intracerebroventricular drug administration","volume":"25","author":"Atkinson","year":"2017","journal-title":"Transl Clin Pharmacol"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/157488811797904362","article-title":"Adult neural stem cells: response to stroke injury and potential for therapeutic applications","volume":"6","author":"Barkho","year":"2011","journal-title":"Curr Stem Cell Res Ther"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1080\/15548627.2023.2165313","article-title":"microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy","volume":"19","author":"Beccari","year":"2023","journal-title":"Autophagy"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41583-019-0132-6","article-title":"Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease","volume":"20","author":"Butterfield","year":"2019","journal-title":"Nat Rev Neurosci"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12979-023-00330-2","article-title":"mitochondrial DNA and inflammatory proteins are higher in extracellular vesicles from frail individuals","volume":"20","author":"Byappanahalli","year":"2023","journal-title":"Immun Ageing"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13195-022-01133-1","article-title":"Proteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer\u2019s disease","volume":"14","author":"Cai","year":"2022","journal-title":"Alzheimers Res Ther"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Candelario-Jalil","year":"2022","journal-title":"Stroke"},{"key":"R13-20260422","first-page":"1499","article-title":"Engineered exosome-mediated near-infrared-II region V (2)C quantum dot delivery for nucleus-target low-temperature photothermal therapy","volume":"13","author":"Cao","year":"2019","journal-title":"ACS Nano"},{"key":"R14-20260422","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1016\/j.neuron.2021.08.011","article-title":"Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2","volume":"109","author":"Chamberlain","year":"2021","journal-title":"Neuron"},{"key":"R15-20260422","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41419-020-2473-5","article-title":"Exosomes derived from mesenchymal stem cells repair a Parkinson\u2019s disease model by inducing autophagy","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis"},{"key":"R16-20260422","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.omtn.2020.09.027","article-title":"Exosome-shuttled circSHOC2 from IPASs regulates neuronal autophagy and ameliorates ischemic brain injury via the miR-7670-3p\/SIRT1 axis","volume":"22","author":"Chen","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"R17-20260422","first-page":"8285065","article-title":"Inhibition of mitochondrial ROS by mitoQ alleviates white matter injury and improves outcomes after intracerebral haemorrhage in mice","volume":"2020","author":"Chen","year":"2020","journal-title":"Oxidmed Cell Longev"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"18274","DOI":"10.18632\/aging.103692","article-title":"mSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in rat","volume":"12","author":"Chen","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"114151","DOI":"10.1016\/j.expneurol.2022.114151","article-title":"Extracellular vesicles derived from bone marrow mesenchymal stem cells alleviate neurological deficit and endothelial cell dysfunction after subarachnoid hemorrhage via the KLF3-AS1\/miR-83-5p\/TCF7L2 axis","volume":"356","author":"Cheng","year":"2022","journal-title":"Exp Neurol"},{"key":"R20-20260422","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nature13909","article-title":"Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS","volume":"515","author":"Chouchani","year":"2014","journal-title":"Nature"},{"key":"R21-20260422","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1113\/JP285170","article-title":"The separation and identification of circulating small extracellular vesicles from endurance-trained, strength-trained and recreationally activemen","volume":"601","author":"Darragh","year":"2023","journal-title":"J Physiol"},{"key":"R22-20260422","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1080\/17425247.2023.2279115","article-title":"Delivery of mitochondria-containing extracellular vesicles to the BBB for ischemic stroke therapy","volume":"20","author":"Dave","year":"2023","journal-title":"Expert Opin Drug Deliv"},{"key":"R23-20260422","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/cvr\/cvac031","article-title":"methods for the identification and characterization of extracellular vesicles in cardiovascular studies: from exosomes to microvesicles","volume":"119","author":"Davidson","year":"2023","journal-title":"Cardiovasc Res"},{"key":"R24-20260422","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13195-023-01303-9","article-title":"Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer\u2019s disease","volume":"15","author":"Delgado-Peraza","year":"2023","journal-title":"Alzheimers Res Ther"},{"key":"R25-20260422","doi-asserted-by":"crossref","first-page":"1123365","DOI":"10.3389\/fncel.2023.1123365","article-title":"Role of gC1qR as amodulator of endothelial cell permeability and contributor to post-stroke inflammation and edema formation","volume":"17","author":"Delgardo","year":"2023","journal-title":"Front Cell Neurosci"},{"key":"R26-20260422","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/s41419-022-05454-9","article-title":"Astrocyte-derived exosomal nicotinamide phosphoribosyltransferase (Nampt) ameliorates ischemic stroke injury by targeting AmPK\/mTOR signaling to induce autophagy","volume":"13","author":"Deng","year":"2022","journal-title":"Cell Death Dis"},{"key":"R27-20260422","doi-asserted-by":"crossref","first-page":"4351","DOI":"10.7150\/thno.52436","article-title":"Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-\u03b2-induced neurotoxicity","volume":"11","author":"Deng","year":"2021","journal-title":"Theranostics"},{"key":"R28-20260422","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1007\/s40618-021-01583-8","article-title":"Extracellular vesicles derived from bone marrow mesenchymal stem cells alleviate neuroinflammation after diabetic intracerebral hemorrhage via themiR-183-5p\/PDCD4\/NLRP3 pathway","volume":"44","author":"Ding","year":"2021","journal-title":"J Endocrinol Invest"},{"key":"R29-20260422","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3390\/cells8070727","article-title":"Overview of extracellular vesicles, their origin, composition, purpose, andmethods for exosome isolation and analysis","volume":"8","author":"Doyle","year":"2019","journal-title":"Cells"},{"key":"R30-20260422","doi-asserted-by":"crossref","first-page":"877","DOI":"10.18632\/aging.202194","article-title":"Coicis semen protects against focal cerebral ischemia-reperfusion injury by inhibiting oxidative stress and promoting angiogenesis via the TGF\u03b2\/ALK1\/Smad1\/5 signaling pathway","volume":"13","author":"Du","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"R31-20260422","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.2147\/DDDT.S255828","article-title":"Exosomes derived from microRNA-146a-5p-enriched bone marrow mesenchymal stem cells alleviate intracerebral hemorrhage by inhibiting neuronal apoptosis and microglialm1 polarization","volume":"14","author":"Duan","year":"2020","journal-title":"Drug Des Devel Ther"},{"key":"R32-20260422","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.3390\/cells9102253","article-title":"Mesenchymal stem cells as a bio-organ for treatment of female infertility","volume":"9","author":"Esfandyari","year":"2020","journal-title":"Cells"},{"key":"R33-20260422","doi-asserted-by":"crossref","first-page":"7624","DOI":"10.1007\/s12010-023-04428-7","article-title":"Leukemia-derived exosomes can induce responses related to tumorigenesis on non-tumoral astrocytes","volume":"195","author":"Esmati","year":"2023","journal-title":"Appl Biochem Biotechnol"},{"key":"R34-20260422","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12967-022-03493-6","article-title":"Role of exosomes in the pathogenesis, diagnosis, and treatment of central nervous system diseases","volume":"20","author":"Fan","year":"2022","journal-title":"J Transl Med"},{"key":"R35-20260422","doi-asserted-by":"crossref","first-page":"105080","DOI":"10.1016\/j.neuint.2021.105080","article-title":"A1\/A2 astrocytes in central nervous system injuries and diseases: angels or devils?","volume":"148","author":"Fan","year":"2021","journal-title":"Neurochem Int"},{"key":"R36-20260422","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s40824-022-00311-4","article-title":"Modified exosomal SIRP\u03b1 variants alleviate white matter injury after intracerebral hemorrhage via microglia\/macrophages","volume":"26","author":"Gao","year":"2022","journal-title":"Biomater Res"},{"key":"R37-20260422","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41419-020-2530-0","article-title":"Extracellular vesicle-mediated transfer of miR-21-5p from mesenchymal stromal cells to neurons alleviates early brain injury to improve cognitive function via the PTEN\/Akt pathway after subarachnoid hemorrhage","volume":"11","author":"Gao","year":"2020","journal-title":"Cell Death Dis"},{"key":"R38-20260422","doi-asserted-by":"crossref","first-page":"117517","DOI":"10.1016\/j.jns.2021.117517","article-title":"Cerebrospinal fluid in COVID-19 neurological complications: neuroaxonal damage, anti-SARS-Cov2 antibodies but no evidence of cytokine storm","volume":"427","author":"Garciam","year":"2021","journal-title":"J Neurol Sci"},{"key":"R39-20260422","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","article-title":"Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"20","year":"2021","journal-title":"Lancet Neurol"},{"key":"R40-20260422","first-page":"16","article-title":"Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: risk-benefit profile and next steps for themarket access","volume":"29","author":"Giovannelli","year":"2023","journal-title":"Bioactmater"},{"key":"R41-20260422","doi-asserted-by":"crossref","first-page":"407","DOI":"10.2147\/JIR.S140188","article-title":"Mechanisms of NF-\u03baB p65 and strategies for therapeutic manipulation","volume":"11","author":"Giridharan","year":"2018","journal-title":"J Inflamm Res"},{"key":"R42-20260422","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s12975-022-01121-5","article-title":"A novel hybrid of telmisartan and borneol ameliorates neuroinflammation and white matter injury in ischemic stroke through ATF3\/CH25H axis","volume":"15","author":"Guan","year":"2024","journal-title":"Transl Stroke Res"},{"key":"R43-20260422","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12951-021-00879-4","article-title":"Surface-modified engineered exosomes attenuated cerebral ischemia\/reperfusion injury by targeting the delivery of quercetin towards impaired neurons","volume":"19","author":"Guo","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"R44-20260422","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3390\/brainsci13040639","article-title":"Intranasal delivery of gene-edited microglial exosomes improves neurological outcomes after intracerebral hemorrhage by regulating neuroinflammation","volume":"13","author":"Guo","year":"2023","journal-title":"Brain Sci"},{"key":"R45-20260422","doi-asserted-by":"crossref","first-page":"815347","DOI":"10.3389\/fnagi.2022.815347","article-title":"Microglia polarization from m1 to m2 in neurodegenerative diseases","volume":"14","author":"Guo","year":"2022","journal-title":"Front Aging Neurosci"},{"key":"R46-20260422","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.2147\/IJN.S291956","article-title":"A comprehensive review on factors influences biogenesis, functions, therapeutic and clinical implications of exosomes","volume":"16","author":"Gurunathan","year":"2021","journal-title":"Int J Nanomedicine"},{"key":"R47-20260422","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1212\/CON.0000000000000416","article-title":"Stroke epidemiology and risk factor management","volume":"23","author":"Guzik","year":"2017","journal-title":"Continuum (Minneapminn)"},{"key":"R48-20260422","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.3390\/cells10081959","article-title":"Mesenchymal stem cell-derived exosomes: applications in regenerative medicine","volume":"10","author":"Hadem","year":"2021","journal-title":"Cells"},{"key":"R49-20260422","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.apsb.2020.11.023","article-title":"Evolution of blood-brain barrier in brain diseases and related systemic nanoscale brain-targeting drug delivery strategies","volume":"11","author":"Han","year":"2021","journal-title":"Acta Pharm Sin B"},{"key":"R50-20260422","doi-asserted-by":"crossref","first-page":"111048","DOI":"10.1016\/j.biopha.2020.111048","article-title":"Mesenchymal stem cell-derived extracellular vesicles promote microglial m2 polarization after subarachnoid hemorrhage in rats and involve the AmPK\/NF-\u03baB signaling pathway","volume":"133","author":"Han","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"R51-20260422","first-page":"290","article-title":"Multipotent mesenchymal stromal cell-derived exosomes improve functional recovery after experimental intracerebral hemorrhage in the rat","volume":"131","author":"Han","year":"2018","journal-title":"J Neurosurg"},{"key":"R52-20260422","doi-asserted-by":"crossref","first-page":"e036990","DOI":"10.1136\/bmjopen-2020-036990","article-title":"Association between plasma exosome neurogranin and brain structure in patients with Alzheimer\u2019s disease: a protocol study","volume":"10","author":"He","year":"2020","journal-title":"BMJ Open"},{"key":"R53-20260422","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/sji.12124","article-title":"The 2013 nobel prize in physiology or medicine","volume":"78","author":"Hellvard","year":"2013","journal-title":"Scand J Immunol"},{"key":"R54-20260422","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.ymthe.2021.09.023","article-title":"Improved post-stroke spontaneous recovery by astrocytic extracellular vesicles","volume":"30","author":"Heras-Romero","year":"2022","journal-title":"Mol Ther"},{"key":"R55-20260422","first-page":"719","article-title":"Stroke: sequelae and rehabilitation","volume":"3","author":"Hewer","year":"1990","journal-title":"Curr Opin Neurol Neurosurg"},{"key":"R56-20260422","doi-asserted-by":"crossref","first-page":"1111617","DOI":"10.3389\/fphar.2023.1111617","article-title":"Development and application of a novel cervical lymph collection method to assess lymphatic transport in rats","volume":"14","author":"Hoang","year":"2023","journal-title":"Front Pharmacol"},{"key":"R57-20260422","doi-asserted-by":"crossref","first-page":"110698","DOI":"10.1016\/j.intimp.2023.110698","article-title":"17-DmAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K\/Akt pathway after intracerebral hemorrhage in rats","volume":"123","author":"Hu","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"R58-20260422","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3390\/biom12070883","article-title":"Exosomes derived from bone marrow mesenchymal stem cells promote angiogenesis in ischemic stroke mice via upregulation of miR-21-5p","volume":"12","author":"Hu","year":"2022","journal-title":"Biomolecules"},{"key":"R59-20260422","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13287-022-03037-1","article-title":"Exosomal miR-17-5p from adipose-derived mesenchymal stem cells inhibits abdominal aortic aneurysm by suppressing TXNIP-NLRP3 inflammasome","volume":"13","author":"Hu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"R60-20260422","doi-asserted-by":"crossref","first-page":"560","DOI":"10.4103\/1673-5374.346551","article-title":"Exosomal miR-23b from bone marrow mesenchymal stem cells alleviates oxidative stress and pyroptosis after intracerebral hemorrhage","volume":"18","author":"Hu","year":"2023","journal-title":"Neural Regen Res"},{"key":"R61-20260422","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actbio.2022.11.057","article-title":"Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing","volume":"157","author":"Hu","year":"2023","journal-title":"Acta Biomater"},{"key":"R62-20260422","doi-asserted-by":"crossref","first-page":"3704","DOI":"10.2174\/138161212802002715","article-title":"Delivery of neurotherapeutics across the blood brain barrier in stroke","volume":"18","author":"Hu","year":"2012","journal-title":"Curr Pharm Des"},{"key":"R63-20260422","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"L\u00f6tvall","year":"2014","journal-title":"J Extracell Vesicles"},{"key":"R64-20260422","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/j.cmet.2021.08.006","article-title":"Exosomes asmediators of intercellular crosstalk inmetabolism","volume":"33","author":"Isaac","year":"2021","journal-title":"Cell Metab"},{"key":"R65-20260422","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12974-019-1516-2","article-title":"Neuroinflammation: friend and foe for ischemic stroke","volume":"16","author":"Jayaraj","year":"2019","journal-title":"J Neuroinflammation"},{"key":"R66-20260422","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biomaterials.2018.06.029","article-title":"NRP-1 targeted and cargo-loaded exosomes facilitate simultaneous imaging and therapy of glioma in vitro and in vivo","volume":"178","author":"Jia","year":"2018","journal-title":"Biomaterials"},{"key":"R67-20260422","doi-asserted-by":"crossref","first-page":"e12332","DOI":"10.1002\/jev2.12332","article-title":"First-in-human clinical trial of allogeneic, platelet-derived extracellular vesicles as a potential therapeutic for delayed wound healing","volume":"12","author":"Johnson","year":"2023","journal-title":"J Extracell Vesicles"},{"key":"R68-20260422","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1182\/blood.V74.5.1844.1844","article-title":"Reticulocyte maturation and exosome release: transferrin receptor containing exosomes shows multiple plasma membrane functions","volume":"74","author":"Johnstone","year":"1989","journal-title":"Blood"},{"key":"R69-20260422","first-page":"367","article-title":"The biology, function, and biomedical applications of exosomes","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"R70-20260422","doi-asserted-by":"crossref","first-page":"280","DOI":"10.2174\/1871520623666230908101204","article-title":"Analysis of inhibition potential of nimbin and its analogs against NF-\u03baB subunits p50 and p65: amolecular docking and molecular dynamics study","volume":"24","author":"Khan","year":"2024","journal-title":"Anticancer Agentsmed Chem"},{"key":"R71-20260422","first-page":"24","article-title":"Themachinery of exosomes: biogenesis, release, and uptake","author":"Krylova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"R72-20260422","doi-asserted-by":"crossref","first-page":"e2103222","DOI":"10.1002\/advs.202103222","article-title":"Exosome processing and characterization approaches for research and technology development","volume":"9","author":"Lai","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"R73-20260422","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12974-020-01745-0","article-title":"Systemic exosomal miR-193b-3p delivery attenuates neuroinflammation in early brain injury after subarachnoid hemorrhage in mice","volume":"17","author":"Lai","year":"2020","journal-title":"J Neuroinflammation"},{"key":"R74-20260422","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.3390\/ijms25126507","article-title":"Emerging roles of exosomes in stroke therapy","volume":"25","author":"Larson","year":"2024","journal-title":"Int J Mol Sci"},{"key":"R75-20260422","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.omtn.2023.03.006","article-title":"Circulating extracellular vesicles promote recovery in a preclinical model of intracerebral hemorrhage","volume":"32","author":"Laso-Garc\u00eda","year":"2023","journal-title":"Mol Ther Nucleic Acids"},{"key":"R76-20260422","doi-asserted-by":"crossref","first-page":"e13283","DOI":"10.1111\/acel.13283","article-title":"Mitochondrial DNA in extracellular vesicles declines with age","volume":"20","author":"Lazo","year":"2021","journal-title":"Aging Cell"},{"key":"R77-20260422","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.3390\/ijms23158367","article-title":"Utility of exosomes in ischemic and hemorrhagic stroke diagnosis and treatment","volume":"23","author":"Lee","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R78-20260422","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/iovs.64.12.11","article-title":"Plasma-derived small extracellular vesicles from VKH patients suppress t cell proliferation via microRNA-410-3p modulation of CXCL5 axis","volume":"64","author":"Li","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R79-20260422","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jconrel.2022.11.053","article-title":"Dendritic cell derived exosomes loaded neoantigens for personalized cancer immunotherapies","volume":"353","author":"Li","year":"2023","journal-title":"J Control Release"},{"key":"R80-20260422","doi-asserted-by":"crossref","first-page":"10811","DOI":"10.1021\/acsnano.2c02898","article-title":"Stimulation by exosomes from hypoxia preconditioned human umbilical vein endothelial cells facilitates mesenchymal stem cells angiogenic function for spinal cord repair","volume":"16","author":"Li","year":"2022","journal-title":"ACS Nano"},{"key":"R81-20260422","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.trsl.2019.12.006","article-title":"Lithium treatmentmitigates white matter injury after intracerebral hemorrhage through brain-derived neurotrophic factor signaling in mice","volume":"217","author":"Li","year":"2020","journal-title":"Transl Res"},{"key":"R82-20260422","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/acsnano.2c10824","article-title":"Inducible pluripotent stem cell-derived small extracellular vesicles rejuvenate senescent blood-brain barrier to protect against ischemic stroke in aged mice","volume":"17","author":"Li","year":"2023","journal-title":"ACS Nano"},{"key":"R83-20260422","doi-asserted-by":"crossref","first-page":"116029","DOI":"10.1016\/j.jep.2022.116029","article-title":"Inhibition of SLC7A11-GPX4 signal pathway is involved in aconitine-induced ferroptosis in vivo and in vitro","volume":"303","author":"Li","year":"2023","journal-title":"J Ethnopharmacol"},{"key":"R84-20260422","doi-asserted-by":"crossref","first-page":"115092","DOI":"10.1016\/j.biopha.2023.115092","article-title":"Neural stem cell-derived extracellular vesicles: the light of central nervous system diseases","volume":"165","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"R85-20260422","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12951-023-01828-z","article-title":"Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke","volume":"21","author":"Li","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"R86-20260422","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.7150\/thno.68895","article-title":"M2 microglia-derived extracellular vesicles promote white matter repair and functional recovery viamiR-23a-5p after cerebral ischemia in mice","volume":"12","author":"Li","year":"2022","journal-title":"Theranostics"},{"key":"R87-20260422","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.7150\/thno.48761","article-title":"M2 microglial small extracellular vesicles reduce glial scar formation via themiR-124\/STAT3 pathway after ischemic stroke in mice","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"R88-20260422","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"R89-20260422","doi-asserted-by":"crossref","first-page":"e2303660","DOI":"10.1002\/adma.202303660","article-title":"Engineering and characterization of an artificial drug-carrying vesicles nanoplatform for enhanced specifically targeted therapy of glioblastoma","volume":"35","author":"Liu","year":"2023","journal-title":"Adv Mater"},{"key":"R90-20260422","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-022-02393-2","article-title":"Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology","volume":"19","author":"Liu","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R91-20260422","doi-asserted-by":"crossref","first-page":"113700","DOI":"10.1016\/j.expneurol.2021.113700","article-title":"Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia m1\/m2 phenotypes","volume":"341","author":"Liu","year":"2021","journal-title":"Exp Neurol"},{"key":"R92-20260422","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1161\/STROKEAHA.123.041783","article-title":"BAG3 overexpression attenuates ischemic stroke injury by activating autophagy and inhibiting apoptosis","volume":"54","author":"Liu","year":"2023","journal-title":"Stroke"},{"key":"R93-20260422","doi-asserted-by":"crossref","first-page":"120578","DOI":"10.1016\/j.carbpol.2023.120578","article-title":"Hyaluronan-based hydrogel integrating exosomes for traumatic brain injury repair by promoting angiogenesis and neurogenesis","volume":"306","author":"Liu","year":"2023","journal-title":"Carbohydr Polym"},{"key":"R94-20260422","doi-asserted-by":"crossref","first-page":"e3062","DOI":"10.1002\/brb3.3062","article-title":"rTMS treatment for abrogating intracerebral hemorrhage-induced brain parenchymalmetabolite clearance dysfunction inmalemice by regulating intracranial lymphatic drainage","volume":"13","author":"Liu","year":"2023","journal-title":"Brain Behav"},{"key":"R95-20260422","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainresbull.2021.07.014","article-title":"MiR-26b-5p-modified hUB-mSCs derived exosomes attenuate early brain injury during subarachnoid hemorrhage viamAT2A-mediated the p38mAPK\/STAT3 signaling pathway","volume":"175","author":"Liu","year":"2021","journal-title":"Brain Res Bull"},{"key":"R96-20260422","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/s41420-023-01440-y","article-title":"Targeting pyroptosis as a preventive and therapeutic approach for stroke","volume":"9","author":"Long","year":"2023","journal-title":"Cell Death Discov"},{"key":"R97-20260422","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","article-title":"Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials","volume":"14","author":"Lotfy","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"R98-20260422","doi-asserted-by":"crossref","first-page":"115847","DOI":"10.1016\/j.biopha.2023.115847","article-title":"Flavonoids and ischemic stroke-induced neuroinflammation: focus on the glial cells","volume":"170","author":"Lu","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"R99-20260422","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1186\/s12964-022-00872-w","article-title":"M2 macrophage-secreted exosomes promotemetastasis and increase vascular permeability in hepatocellular carcinoma","volume":"21","author":"Lu","year":"2023","journal-title":"Cell Commun Signal"},{"key":"R100-20260422","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/cns.13902","article-title":"Rab27a-dependent exosomes protect against cerebral ischemic injury by reducing endothelial oxidative stress and apoptosis","volume":"28","author":"Ma","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"R101-20260422","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/cbf.3484","article-title":"Effects of neural stem cell-derived extracellular vesicles on neuronal protection and functional recovery in the rat model of middle cerebral artery occlusion","volume":"38","author":"Mahdavipour","year":"2020","journal-title":"Cell Biochem Funct"},{"key":"R102-20260422","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jconrel.2023.01.059","article-title":"Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer\/delivery","volume":"354","author":"Malekpour","year":"2023","journal-title":"J Control Release"},{"key":"R103-20260422","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1007\/s12264-022-00859-0","article-title":"Neuronal deathmechanisms and therapeutic strategy in ischemic stroke","volume":"38","author":"Mao","year":"2022","journal-title":"Neurosci Bull"},{"key":"R104-20260422","doi-asserted-by":"crossref","first-page":"269","DOI":"10.31083\/j.fbl2810269","article-title":"Microglia and stem cells for ischemic stroke treatment-mechanisms, current status, and therapeutic challenges","volume":"28","author":"Markowska","year":"2023","journal-title":"Front Biosci"},{"key":"R105-20260422","first-page":"105","article-title":"Applications of fractal analysis techniques in magnetic resonance imaging and computed tomography for stroke diagnosis and stroke-related brain damage: a narrative review","volume":"1","author":"Maryenko","year":"2024","journal-title":"Adv Technol Neurosci"},{"key":"R106-20260422","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.3390\/ijms23126480","article-title":"Therapeutic strategy of mesenchymal-stem-cell-derived extracellular vesicles as regenerative medicine","volume":"23","author":"Matsuzaka","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R107-20260422","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.jconrel.2022.12.027","article-title":"Hybrid exosomes, exosome-like nanovesicles and engineered exosomes for therapeutic applications","volume":"353","author":"Mondal","year":"2023","journal-title":"J Control Release"},{"key":"R108-20260422","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/jps.24251","article-title":"Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice","volume":"104","author":"Morishita","year":"2015","journal-title":"J Pharm Sci"},{"key":"R109-20260422","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jim.2014.06.007","article-title":"Isolation of biologically-active exosomes from human plasma","volume":"411","author":"Muller","year":"2014","journal-title":"J Immunol Methods"},{"key":"R110-20260422","doi-asserted-by":"crossref","first-page":"112579","DOI":"10.1016\/j.msec.2021.112579","article-title":"Therapeutic applications of exosomes in various diseases: a review","volume":"134","author":"N V Lakshmi Kavya","year":"2022","journal-title":"Biomater Adv"},{"key":"R111-20260422","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/s41578-021-00394-w","article-title":"Drug delivery to the central nervous system","volume":"7","author":"Nance","year":"2022","journal-title":"Nat Rev Mater"},{"key":"R112-20260422","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1111\/jocd.14537","article-title":"Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics","volume":"20","author":"Nestorm","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"R113-20260422","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s10456-020-09742-w","article-title":"Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice","volume":"24","author":"Nguyen","year":"2021","journal-title":"Angiogenesis"},{"key":"R114-20260422","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/s13105-023-00969-x","article-title":"Exercise-derived skeletal myogenic exosomes as mediators of intercellular crosstalk: a major player in health, disease, and exercise","volume":"79","author":"Ni","year":"2023","journal-title":"J Physiol Biochem"},{"key":"R115-20260422","doi-asserted-by":"crossref","first-page":"102363","DOI":"10.1016\/j.redox.2022.102363","article-title":"Ginsenoside Rb1 inhibits astrocyte activation and promotes transfer of astrocytic mitochondria to neurons against ischemic stroke","volume":"54","author":"Ni","year":"2022","journal-title":"Redox Biol"},{"key":"R116-20260422","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/aja.1001410203","article-title":"Secretory processes in follicular cells of the bat thyroid. 3. The occurrence of extracellular vesicles and colloid droplets during arousal from hibernation","volume":"141","author":"Nunez","year":"1974","journal-title":"Am J Anat"},{"key":"R117-20260422","doi-asserted-by":"crossref","DOI":"10.3791\/63540","article-title":"Intraventricular drug delivery and sampling for pharmacokinetics and pharmacodynamics study","author":"Oberrauch","year":"2022","journal-title":"J Vis Exp"},{"key":"R118-20260422","doi-asserted-by":"crossref","first-page":"44433","DOI":"10.1038\/srep44433","article-title":"White matter repair after extracellular vesicles administration in an experimental animal model of subcortical stroke","volume":"7","author":"Otero-Ortega","year":"2017","journal-title":"Sci Rep"},{"key":"R119-20260422","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/0092-8674(83)90040-5","article-title":"Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor","volume":"33","author":"Pan","year":"1983","journal-title":"Cell"},{"key":"R120-20260422","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1007\/s12035-023-03280-4","article-title":"MiR-17-5p mediates the effects of ACE2-enriched endothelial progenitor cell-derived exosomes on ameliorating cerebral ischemic injury in aged mice","volume":"60","author":"Pan","year":"2023","journal-title":"Mol Neurobiol"},{"key":"R121-20260422","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/btm2.10065","article-title":"Impact of cell culture parameters on production and vascularization bioactivity of mesenchymal stem cell-derived extracellular vesicles","volume":"2","author":"Patel","year":"2017","journal-title":"Bioeng Transl Med"},{"key":"R122-20260422","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s13311-021-01076-9","article-title":"Mesenchymal stem cell (MSC)-derived extracellular vesicles protect from neonatal stroke by interacting with microglial cells","volume":"18","author":"Pathipati","year":"2021","journal-title":"Neurotherapeutics"},{"key":"R123-20260422","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/stmcls\/sxac020","article-title":"Human induced pluripotent stem cells: from cell origin, genomic stability, and epigenetic memory to translational medicine","volume":"40","author":"Poetschm","year":"2022","journal-title":"Stem Cells"},{"key":"R124-20260422","doi-asserted-by":"crossref","first-page":"102320","DOI":"10.1016\/j.tice.2024.102320","article-title":"Mesenchymal stem cells and their extracellular vesicles as emerging therapeutic tools in the treatment of ischemic stroke","volume":"87","author":"Pratiwi","year":"2024","journal-title":"Tissue Cell"},{"key":"R125-20260422","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/ijnp\/pyab096","article-title":"Mesenchymal stem cell-derived extracellular vesicles alleviate m1 microglial activation in brain injury of mice with subarachnoid hemorrhage via microRNA-140-5p delivery","volume":"25","author":"Qian","year":"2022","journal-title":"Int J Neuropsychopharmacol"},{"key":"R126-20260422","doi-asserted-by":"crossref","first-page":"119826","DOI":"10.1016\/j.biomaterials.2020.119826","article-title":"Effects of exosome-mediated delivery of myostatin propeptide on functional recovery of mdx mice","volume":"236","author":"Ran","year":"2020","journal-title":"Biomaterials"},{"key":"R127-20260422","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1084\/jem.183.3.1161","article-title":"B lymphocytes secrete antigen-presenting vesicles","volume":"183","author":"Raposo","year":"1996","journal-title":"J Exp Med"},{"key":"R128-20260422","doi-asserted-by":"crossref","first-page":"6670","DOI":"10.1021\/acsnano.9b01004","article-title":"Stem cell-derived exosomes as nanotherapeutics for autoimmune and neurodegenerative disorders","volume":"13","author":"Riazifar","year":"2019","journal-title":"ACS Nano"},{"key":"R129-20260422","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/STROKEAHA.122.041729","article-title":"Therapies targeting stroke recovery","volume":"54","author":"Richards","year":"2023","journal-title":"Stroke"},{"key":"R130-20260422","doi-asserted-by":"crossref","first-page":"20083","DOI":"10.1074\/jbc.M301642200","article-title":"Exosome release is regulated by a calcium-dependent mechanism in K562 cells","volume":"278","author":"Savina","year":"2003","journal-title":"J Biol Chem"},{"key":"R131-20260422","doi-asserted-by":"crossref","first-page":"690","DOI":"10.18063\/ijb.690","article-title":"Bioprinting of exosomes: prospects and challenges for clinical applications","volume":"9","author":"Selvam","year":"2023","journal-title":"Int J Bioprint"},{"key":"R132-20260422","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/pharmaceutics15010036","article-title":"Intranasal delivery of liposomes to glioblastoma by photostimulation of the lymphatic system","volume":"15","author":"Semyachkina-Glushkovskaya","year":"2022","journal-title":"Pharmaceutics"},{"key":"R133-20260422","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1089\/scd.2020.0080","article-title":"Exosomes derived from bone marrow mesenchymal stem cells as treatment for severe COVID-19","volume":"29","author":"Sengupta","year":"2020","journal-title":"Stem Cells Dev"},{"key":"R134-20260422","first-page":"76","article-title":"Advances in stem cell therapy for stroke: mechanisms, challenges, and future directions","volume":"1","author":"Sheikh","year":"2024","journal-title":"Regen Med Rep"},{"key":"R135-20260422","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12031-018-1041-2","article-title":"Role of exosomes derived from miR-133b modified MSCs in an experimental rat model of intracerebral hemorrhage","volume":"64","author":"Shen","year":"2018","journal-title":"J Mol Neurosci"},{"key":"R136-20260422","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1007\/s10571-023-01382-0","article-title":"The pathological mechanism of neuronal autophagy-lysosome dysfunction after ischemic stroke","volume":"43","author":"Shi","year":"2023","journal-title":"Cellmol Neurobiol"},{"key":"R137-20260422","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/10715762.2020.1867314","article-title":"Recent advances in iron homeostasis and regulation - a focus on epigenetic regulation and stroke","volume":"55","author":"Shi","year":"2021","journal-title":"Free Radic Res"},{"key":"R138-20260422","doi-asserted-by":"crossref","first-page":"e12134","DOI":"10.1002\/jev2.12134","article-title":"Preclinical efficacy and clinical safety of clinical-grade nebulized allogenic adipose mesenchymal stromal cells-derived extracellular vesicles","volume":"10","author":"Shim","year":"2021","journal-title":"J Extracell Vesicles"},{"key":"R139-20260422","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molimm.2021.03.017","article-title":"Serum-derived exosomes function as tumor antigens in patients with advanced hepatocellular carcinoma","volume":"134","author":"Shi","year":"2021","journal-title":"Mol Immunol"},{"key":"R140-20260422","doi-asserted-by":"crossref","first-page":"175477","DOI":"10.1016\/j.ejphar.2022.175477","article-title":"Exosomes as biomarkers and therapeutic measures for ischemic stroke","volume":"939","author":"Shi","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"R141-20260422","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1194\/jlr.R084343","article-title":"Exosomal lipid composition and the role of ether lipids and phosphoinositides in exosome biology","volume":"60","author":"Skotland","year":"2019","journal-title":"J Lipid Res"},{"key":"R142-20260422","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41467-019-09720-x","article-title":"KIBRA controls exosome secretion via inhibiting the proteasomal degradation of Rab27a","volume":"10","author":"Song","year":"2019","journal-title":"Nat Commun"},{"key":"R143-20260422","doi-asserted-by":"crossref","first-page":"104558","DOI":"10.1016\/j.ebiom.2023.104558","article-title":"Open pathways for cerebrospinal fluid outflow at the cribriform plate along the olfactory nerves","volume":"91","author":"Spera","year":"2023","journal-title":"EBiomedicine"},{"key":"R144-20260422","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1007\/s12015-023-10541-1","article-title":"Mesenchymal stem cell-derived exosomal miR-150-3p affects intracerebral hemorrhage by regulating TRAF6\/NF-\u03baB axis, gut microbiota and metabolism","volume":"19","author":"Sun","year":"2023","journal-title":"Stem Cell Rev Rep"},{"key":"R145-20260422","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1161\/CIRCRESAHA.119.315886","article-title":"Endothelium-targeted deletion of microRNA-15a\/16-1 promotes poststroke angiogenesis and improves long-term neurological recovery","volume":"126","author":"Sun","year":"2020","journal-title":"Circ Res"},{"key":"R146-20260422","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/s41392-023-01704-0","article-title":"Clinical applications of stem cell-derived exosomes","volume":"9","author":"Tan","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"R147-20260422","doi-asserted-by":"crossref","first-page":"113938","DOI":"10.1016\/j.colsurfb.2024.113938","article-title":"Exosomes: the endogenous nanomaterials packed with potential for diagnosis and treatment of neurologic disorders","volume":"239","author":"Tang","year":"2024","journal-title":"Colloids Surf B Biointerfaces"},{"key":"R148-20260422","doi-asserted-by":"crossref","first-page":"106020","DOI":"10.1016\/j.nbd.2023.106020","article-title":"Pharmacological inhibition of lysosomal two-pore channel 2 (TPC2) confers neuroprotection in stroke via autophagy regulation","volume":"178","author":"Tedeschi","year":"2023","journal-title":"Neurobiol Dis"},{"key":"R149-20260422","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"R150-20260422","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.7150\/thno.56367","article-title":"Targeted delivery of neural progenitor cell-derived extracellular vesicles for anti-inflammation after cerebral ischemia","volume":"11","author":"Tian","year":"2021","journal-title":"Theranostics"},{"key":"R151-20260422","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1161\/STROKEAHA.121.037834","article-title":"Functional investigation of meningeal lymphatic system in experimental intracerebral hemorrhage","volume":"53","author":"Tsai","year":"2022","journal-title":"Stroke"},{"key":"R152-20260422","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/978-3-030-31206-0_4","article-title":"Neural stem cells","volume":"1201","author":"Tuazon","year":"2019","journal-title":"Adv Expmed Biol"},{"key":"R153-20260422","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1021\/acs.biochem.3c00371","article-title":"Lipid nanoparticles deliver mRNA to the brain after an intracerebral injection","volume":"62","author":"Tuma","year":"2023","journal-title":"Biochemistry"},{"key":"R154-20260422","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/med.21817","article-title":"Mechanisms of neuronal cell death in ischemic stroke and their therapeutic implications","volume":"42","author":"Tuo","year":"2022","journal-title":"Med Res Rev"},{"key":"R155-20260422","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.neuron.2019.09.026","article-title":"Quiescence of adult mammalian neural stem cells: a highly regulated rest","volume":"104","author":"Urb\u00e1n","year":"2019","journal-title":"Neuron"},{"key":"R156-20260422","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol"},{"key":"R157-20260422","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Revmol Cell Biol"},{"key":"R158-20260422","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3233\/NPM-200477","article-title":"Commentary - exosomes: realization of the great therapeutic potential of stem cells","volume":"13","author":"Volpe","year":"2020","journal-title":"J Neonatal Perinatalmed"},{"key":"R159-20260422","doi-asserted-by":"crossref","first-page":"e14","DOI":"10.1161\/STROKEAHA.121.035821","article-title":"Postischemic neuroprotection associated with anti-inflammatory effects by mesenchymal stromal cell-derived small extracellular vesicles in aged mice","volume":"53","author":"Wang","year":"2022","journal-title":"Stroke"},{"key":"R160-20260422","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ace39c","article-title":"The role of exosomes in central nervous system tissue regeneration and repair","author":"Wang","year":"2023","journal-title":"Biomed Mater"},{"key":"R161-20260422","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.2174\/011574888X266357230923113642","article-title":"Themir-210 primed endothelial progenitor cell exosomes alleviate acute ischemic brain injury","volume":"19","author":"Wang","year":"2023","journal-title":"Curr Stem Cell Res Ther"},{"key":"R162-20260422","doi-asserted-by":"crossref","first-page":"120784","DOI":"10.1016\/j.biomaterials.2021.120784","article-title":"Inflammatory tumor microenvironment responsive neutrophil exosomes-based drug delivery system for targeted glioma therapy","volume":"273","author":"Wang","year":"2021","journal-title":"Biomaterials"},{"key":"R163-20260422","doi-asserted-by":"crossref","first-page":"114265","DOI":"10.1016\/j.expneurol.2022.114265","article-title":"MicroRNA-140-5p shuttled by microglia-derived extracellular vesicles attenuates subarachnoid hemorrhage-induced microglia activation and inflammatory response via MMD downregulation","volume":"359","author":"Wang","year":"2023","journal-title":"Exp Neurol"},{"key":"R164-20260422","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1007\/s12035-023-03301-2","article-title":"Bone marrow mesenchymal stem cell-derived exosomal KLF4 alleviated ischemic stroke through inhibiting n6-methyladenosine modification level of Drp1 by targeting lncRNA-ZFAS1","volume":"60","author":"Wang","year":"2023","journal-title":"Mol Neurobiol"},{"key":"R165-20260422","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.4103\/1673-5374.391313","article-title":"Emerging strategies for nerve repair and regeneration in ischemic stroke: neural stem cell therapy","volume":"19","author":"Wang","year":"2024","journal-title":"Neural Regen Res"},{"key":"R166-20260422","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1002\/lsm.23628","article-title":"Stem cell-derived exosomes in the treatment of melasma and its percutaneous penetration","volume":"55","author":"Wang","year":"2023","journal-title":"Lasers Surgmed"},{"key":"R167-20260422","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000488365","article-title":"Diagnosis of hyperacute and acute ischaemic stroke: the potential utility of exosomal microRNA-21-5p andmicroRNA-30a-5p","volume":"45","author":"Wang","year":"2018","journal-title":"Cerebrovasc Dis"},{"key":"R168-20260422","doi-asserted-by":"crossref","first-page":"e23346","DOI":"10.1002\/jbt.23346","article-title":"Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6\/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage","volume":"37","author":"Wang","year":"2023","journal-title":"J Biochemmol Toxicol"},{"key":"R169-20260422","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1365-2141.1967.tb08741.x","article-title":"The nature and significance of platelet products in human plasma","volume":"13","author":"Wolf","year":"1967","journal-title":"Br J Haematol"},{"key":"R170-20260422","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.7150\/thno.69533","article-title":"AdmSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages","volume":"12","author":"Xia","year":"2022","journal-title":"Theranostics"},{"key":"R171-20260422","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3389\/fnmol.2019.00098","article-title":"TRPA1 activation-induced myelin degradation plays a key role in motor dysfunction after intracerebral hemorrhage","volume":"12","author":"Xia","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"R172-20260422","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/acsnano.1c00672","article-title":"Embryonic stem cell derived small extracellular vesicles modulate regulatory t cells to protect against ischemic stroke","volume":"15","author":"Xia","year":"2021","journal-title":"ACS Nano"},{"key":"R173-20260422","doi-asserted-by":"crossref","first-page":"110586","DOI":"10.1016\/j.cellsig.2022.110586","article-title":"The autophagy in ischemic stroke: a regulatory role of non-coding-RNAs","volume":"104","author":"Xiaoqing","year":"2023","journal-title":"Cell Signal"},{"key":"R174-20260422","first-page":"3","article-title":"Bone marrow mesenchymal stem cell-derived exosomal lncRNA KLF3-AS1 stabilizes Sirt1 protein to improve cerebral ischemia\/reperfusion injury viamiR-206\/USP22 axis","volume":"29","author":"Xie","year":"2023","journal-title":"Molmed"},{"key":"R175-20260422","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1038\/jcbfm.2013.152","article-title":"Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats","volume":"33","author":"Xin","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"R176-20260422","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1177\/0271678X20950489","article-title":"MiR-17-92 enriched exosomes derived from multipotent mesenchymal stromal cells enhance axon-myelin remodeling andmotor electrophysiological recovery after stroke","volume":"41","author":"Xin","year":"2021","journal-title":"J Cereb Blood Flow Metab"},{"key":"R177-20260422","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1089\/scd.2019.0206","article-title":"Exosomes from bone marrow mesenchymal stem cells can alleviate early brain injury after subarachnoid hemorrhage through miRNA129-5p-HMGB1 pathway","volume":"29","author":"Xiong","year":"2020","journal-title":"Stem Cells Dev"},{"key":"R178-20260422","doi-asserted-by":"crossref","first-page":"747380","DOI":"10.3389\/fneur.2021.747380","article-title":"Exosomal microRNAs as potential biomarkers and therapeutic agents for acute ischemic stroke: new expectations","volume":"12","author":"Xu","year":"2021","journal-title":"Front Neurol"},{"key":"R179-20260422","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"key":"R180-20260422","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.7150\/thno.41580","article-title":"Progress, opportunity, and perspective on exosome isolation - efforts for efficient exosome-based theranostics","volume":"10","author":"Yang","year":"2020","journal-title":"Theranostics"},{"key":"R181-20260422","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1007\/s11011-022-00997-4","article-title":"Bone marrow mesenchymal stem cell-derived exosomes carrying long noncoding RNA ZFAS1 alleviate oxidative stress and inflammation in ischemic stroke by inhibitingmicroRNA-15a-5p","volume":"37","author":"Yang","year":"2022","journal-title":"Metab Brain Dis"},{"key":"R182-20260422","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.omtn.2017.04.010","article-title":"Exosome mediated delivery of miR-124 promotes neurogenesis after ischemia","volume":"7","author":"Yang","year":"2017","journal-title":"Mol Ther Nucleic Acids"},{"key":"R183-20260422","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.omtn.2020.06.013","article-title":"Therapeutic effects of simultaneous delivery of nerve growth factor mRNA and protein via exosomes on cerebral ischemia","volume":"21","author":"Yang","year":"2020","journal-title":"Mol Ther Nucleic Acids"},{"key":"R184-20260422","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1161\/STROKEAHA.123.043391","article-title":"Oxytocin improves intracerebral hemorrhage outcomes by suppressing neuronal pyroptosis and mitochondrial fission","volume":"54","author":"Yang","year":"2023","journal-title":"Stroke"},{"key":"R185-20260422","doi-asserted-by":"crossref","first-page":"1198546","DOI":"10.3389\/fneur.2023.1198546","article-title":"Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions","volume":"14","author":"Yang","year":"2023","journal-title":"Front Neurol"},{"key":"R186-20260422","doi-asserted-by":"crossref","first-page":"151","DOI":"10.7150\/ijms.86591","article-title":"Bibliometric analysis of stem cells in ischemic stroke (2001-2022): Trends, hotspots and prospects","volume":"21","author":"Yang","year":"2024","journal-title":"Int J Med Sci"},{"key":"R187-20260422","first-page":"1","article-title":"Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury","volume":"27","author":"Yang","year":"2023","journal-title":"Bioactmater"},{"key":"R188-20260422","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.2174\/1570159X18666200720173316","article-title":"Angiogenesis and blood-brain barrier permeability in vascular remodeling after stroke","volume":"18","author":"Yang","year":"2020","journal-title":"Curr Neuropharmacol"},{"key":"R189-20260422","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.hest.2022.06.001","article-title":"Glymphatic system and post-hemorrhagic hydrocephalus","volume":"4","author":"Ye","year":"2023","journal-title":"Brain Hemorrhages"},{"key":"R190-20260422","doi-asserted-by":"crossref","first-page":"12341","DOI":"10.1021\/acsami.7b18135","article-title":"Methotrexate-loaded extracellular vesicles functionalized with therapeutic and targeted peptides for the treatment of glioblastoma multiforme","volume":"10","author":"Ye","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"R191-20260422","doi-asserted-by":"crossref","first-page":"661317","DOI":"10.3389\/fcell.2021.661317","article-title":"Exosomes FrommiR-19b-3p-modified ADSCs Inhibit Ferroptosis in Intracerebral Hemorrhage mice","volume":"9","author":"Yi","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"R192-20260422","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","article-title":"Exosome-based liquid biopsies in cancer: opportunities and challenges","volume":"32","author":"Yu","year":"2021","journal-title":"Ann Oncol"},{"key":"R193-20260422","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10143-023-02106-0","article-title":"Treatment and prognostic risk factors for intracranial infection after craniocerebral surgery","volume":"46","author":"Yue","year":"2023","journal-title":"Neurosurg Rev"},{"key":"R194-20260422","first-page":"25","article-title":"Activated Drp1 regulates p62-mediated autophagic flux and aggravates inflammation in cerebral ischemia-reperfusion via the ROS-RIP1\/RIP3-exosome axis","volume":"9","author":"Zeng","year":"2022","journal-title":"Mil Med Res"},{"key":"R195-20260422","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1093\/neuonc\/noac071","article-title":"Blood exosomes-based targeted delivery of cPLA2 siRNA and metformin to modulate glioblastoma energy metabolism for tailoring personalized therapy","volume":"24","author":"Zhan","year":"2022","journal-title":"Neuro Oncol"},{"key":"R196-20260422","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.18632\/aging.202373","article-title":"Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"R197-20260422","doi-asserted-by":"crossref","first-page":"107369","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107369","article-title":"Bone marrow mesenchymal stem cells-derived exosomes mediated delivery of tetramethylpyrazine attenuate cerebral ischemic injury","volume":"32","author":"Zhang","year":"2023","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"R198-20260422","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jare.2020.05.017","article-title":"Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model","volume":"24","author":"Zhang","year":"2020","journal-title":"J Adv Res"},{"key":"R199-20260422","doi-asserted-by":"crossref","first-page":"113895","DOI":"10.1016\/j.expneurol.2021.113895","article-title":"Exosomes derived from bone marrow mesenchymal stromal cells promote remyelination and reduce neuroinflammation in the demyelinating central nervous system","volume":"347","author":"Zhang","year":"2022","journal-title":"Exp Neurol"},{"key":"R200-20260422","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41419-021-04363-7","article-title":"Extracellular vesicles from hypoxia-preconditioned microglia promote angiogenesis and repress apoptosis in stroke mice via the TGF-\u03b2\/Smad2\/3 pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Cell Death Dis"},{"key":"R201-20260422","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1016\/j.apsb.2023.03.018","article-title":"Peripheral origin exosomal microRNAs aggravate glymphatic system dysfunction in diabetic cognitive impairment","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"R202-20260422","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1161\/ATVBAHA.120.315031","article-title":"Neural progenitor cell-derived extracellular vesicles enhance blood-brain barrier integrity by NF-\u03baB (nuclear factor-\u03bab)-dependent regulation of ABCB1 (ATP-binding cassette transporter B1) in stroke mice","volume":"41","author":"Zhang","year":"2021","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R203-20260422","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41392-023-01382-y","article-title":"Engineered exosomes from different sources for cancer-targeted therapy","volume":"8","author":"Zhang","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"R204-20260422","doi-asserted-by":"crossref","first-page":"e84493","DOI":"10.7554\/eLife.84493","article-title":"NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice","volume":"12","author":"Zhang","year":"2023","journal-title":"Elife"},{"key":"R205-20260422","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2022.01.002","article-title":"ICAm-1-mediated adhesion is a prerequisite for exosome-induced T cell suppression","volume":"57","author":"Zhang","year":"2022","journal-title":"Dev Cell"},{"key":"R206-20260422","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/mgr.MEDGASRES-D-24-00005","article-title":"Ozone: complicated effects in central nervous system diseases","volume":"15","author":"Zhang","year":"2025","journal-title":"Med Gas Res"},{"key":"R207-20260422","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1007\/s00441-023-03754-w","article-title":"MiR-18a-5p shuttled by mesenchymal stem cell-derived extracellular vesicles alleviates early brain injury following subarachnoid hemorrhage through blockade of the ENC1\/p62 axis","volume":"392","author":"Zhang","year":"2023","journal-title":"Cell Tissue Res"},{"key":"R208-20260422","doi-asserted-by":"crossref","first-page":"5107","DOI":"10.1016\/j.apsb.2023.06.011","article-title":"Mitochondrial-targeted and ROS-responsive nanocarrier via nose-to-brain pathway for ischemic stroke treatment","volume":"13","author":"Zhang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"R209-20260422","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12951-022-01245-8","article-title":"Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis","volume":"20","author":"Zhang","year":"2022","journal-title":"J Nanobiotechnology"},{"key":"R210-20260422","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13287-022-03202-6","article-title":"Stability and biosafety of human epidermal stem cell for wound repair: preclinical evaluation","volume":"14","author":"Zhao","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"R211-20260422","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1007\/s11064-020-02998-0","article-title":"MSCs-derived exosomes attenuate acute brain injury and inhibit microglial inflammation by reversing CysLT2R-ERK1\/2 mediated microgliam1 polarization","volume":"45","author":"Zhao","year":"2020","journal-title":"Neurochem Res"},{"key":"R212-20260422","doi-asserted-by":"crossref","first-page":"134","DOI":"10.31083\/j.jin2205134","article-title":"Autophagy in intracerebral hemorrhage: from mechanism to regulation","volume":"22","author":"Zheng","year":"2023","journal-title":"J Integr Neurosci"},{"key":"R213-20260422","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12974-021-02101-6","article-title":"Ceria nanoparticles ameliorate white matter injury after intracerebral hemorrhage: microglia-astrocyte involvement in remyelination","volume":"18","author":"Zheng","year":"2021","journal-title":"J Neuroinflammation"},{"key":"R214-20260422","doi-asserted-by":"crossref","first-page":"639","DOI":"10.7150\/ijms.51150","article-title":"Clemastine promotes recovery of neural function and suppresses neuronal apoptosis by restoring balance of pro-inflammatory mediators in an experimental model of intracerebral hemorrhage","volume":"18","author":"Zhi","year":"2021","journal-title":"Int J Med Sci"},{"key":"R215-20260422","first-page":"12","article-title":"Exosomes in cerebral ischemia-reperfusion injury: current perspectives and future challenges","author":"Zhou","year":"2022","journal-title":"Brain Sci"},{"key":"R216-20260422","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbrc.2022.09.089","article-title":"MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1","volume":"632","author":"Zhou","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"R217-20260422","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1186\/s13287-022-02980-3","article-title":"Human adipose-derived mesenchymal stem cells-derived exosomes encapsulated in pluronic F127 hydrogel promote wound healing and regeneration","volume":"13","author":"Zhou","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"R218-20260422","doi-asserted-by":"crossref","first-page":"1223349","DOI":"10.3389\/fnut.2023.1223349","article-title":"Ginger: a representative material of herb-derived exosome-like nanoparticles","volume":"10","author":"Zhu","year":"2023","journal-title":"Front Nutr"},{"key":"R219-20260422","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1161\/STROKEAHA.123.045941","article-title":"Glymphatic system impairment contributes to the formation of brain edema after ischemic stroke","volume":"55","author":"Zhu","year":"2024","journal-title":"Stroke"},{"key":"R220-20260422","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4103\/1673-5374.346466","article-title":"Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke","volume":"18","author":"Zhu","year":"2023","journal-title":"Neural Regen Res"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:43:05Z","timestamp":1787838185000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,7]]},"references-count":220,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-00665","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,7]]},"assertion":[{"value":"2024-07-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}