{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T07:37:12Z","timestamp":1793777832754,"version":"4.6.1"},"reference-count":180,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T00:00:00Z","timestamp":1736726400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Ischemic stroke is a significant global health crisis, frequently resulting in disability or death, with limited therapeutic interventions available. Although various intrinsic reparative processes are initiated within the ischemic brain, these mechanisms are often insufficient to restore neuronal functionality. This has led to intensive investigation into the use of exogenous stem cells as a potential therapeutic option. This comprehensive review outlines the ontogeny and mechanisms of activation of endogenous neural stem cells within the adult brain following ischemic events, with focus on the impact of stem cell-based therapies on neural stem cells. Exogenous stem cells have been shown to enhance the proliferation of endogenous neural stem cells via direct cell-to-cell contact and through the secretion of growth factors and exosomes. Additionally, implanted stem cells may recruit host stem cells from their niches to the infarct area by establishing so-called \u201cbiobridges.\u201d Furthermore, xenogeneic and allogeneic stem cells can modify the microenvironment of the infarcted brain tissue through immunomodulatory and angiogenic effects, thereby supporting endogenous neuroregeneration. Given the convergence of regulatory pathways between exogenous and endogenous stem cells and the necessity for a supportive microenvironment, we discuss three strategies to simultaneously enhance the therapeutic efficacy of both cell types. These approaches include: (1) co-administration of various growth factors and pharmacological agents alongside stem cell transplantation to reduce stem cell apoptosis; (2) synergistic administration of stem cells and their exosomes to amplify paracrine effects; and (3) integration of stem cells within hydrogels, which provide a protective scaffold for the implanted cells while facilitating the regeneration of neural tissue and the reconstitution of neural circuits. This comprehensive review highlights the interactions and shared regulatory mechanisms between endogenous neural stem cells and exogenously implanted stem cells and may offer new insights for improving the efficacy of stem cell-based therapies in the treatment of ischemic stroke.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-00879","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T05:00:20Z","timestamp":1737090020000},"page":"212-223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Enhanced neurogenesis after ischemic stroke: The interplay between endogenous and exogenous stem cells"],"prefix":"10.4103","volume":"21","author":[{"given":"Ruxu","family":"Geng","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6701-2474","authenticated-orcid":false,"given":"Jun","family":"Wu","sequence":"additional","affiliation":[{"name":"Stanford Cancer Institute, Stanford University, Stanford, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-7692","authenticated-orcid":false,"given":"Xinjie","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China"},{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/ahe.12496","article-title":"Adult neurogenesis in the mammalian dentate gyrus","volume":"49","author":"Abbott","year":"2020","journal-title":"Anat Histol Embryol"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature03994","article-title":"In vivo analysis of quiescent adult neural stem cells responding to Sonic hedgehog","volume":"437","author":"Ahn","year":"2005","journal-title":"Nature"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"8","DOI":"10.21037\/sci-2020-001","article-title":"Current state of stem cell-based therapies: an overview","volume":"7","author":"Aly","year":"2020","journal-title":"Stem Cell Investig"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1177\/154596830001400302","article-title":"Neuroimaging of recovery of function after stroke: implications for rehabilitation","volume":"14","author":"Ances","year":"2000","journal-title":"Neurorehabil Neural Repair"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.semcdb.2019.01.005","article-title":"Neural stem cell niche heterogeneity","volume":"95","author":"Andreotti","year":"2019","journal-title":"Semin Cell Dev Biol"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: developmental, physiological, and pathological perspectives, problems, and promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Dev Cell"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1016\/j.celrep.2017.11.050","article-title":"A single-cell RNA sequencing study reveals cellular and molecular dynamics of the hippocampal neurogenic niche","volume":"21","author":"Artegiani","year":"2017","journal-title":"Cell Rep"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.3390\/ijms23126827","article-title":"Recent advances on the role of brain-derived neurotrophic factor (bdnf) in neurodegenerative diseases","volume":"23","author":"Azman","year":"2022","journal-title":"Int J Mol Sci"},{"key":"R9-20260422","doi-asserted-by":"crossref","first-page":"e00972","DOI":"10.1002\/prp2.972","article-title":"The efficacy and safety of fingolimod plus standardized treatment versus standardized treatment alone for acute ischemic stroke: a systematic review and meta-analysis","volume":"10","author":"Bai","year":"2022","journal-title":"Pharmacol Res Perspect"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.stemcr.2015.04.008","article-title":"A hyaluronan-based injectable hydrogel improves the survival and integration of stem cell progeny following transplantation","volume":"4","author":"Ballios","year":"2015","journal-title":"Stem Cell Rep"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.brainres.2010.10.063","article-title":"Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats","volume":"1367","author":"Bao","year":"2011","journal-title":"Brain Res"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1038\/sj.jcbfm.9600153","article-title":"Reappearance of hippocampal CA1 neurons after ischemia is associated with recovery of learning and memory","volume":"25","author":"Bendel","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"R13-20260422","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cell.2019.02.010","article-title":"A common embryonic origin of stem cells drives developmental and adult neurogenesis","volume":"177","author":"Berg","year":"2019","journal-title":"Cell"},{"key":"R14-20260422","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1411587","article-title":"A randomized trial of intraarterial treatment for acute ischemic stroke","volume":"372","author":"Berkhemer","year":"2015","journal-title":"New Engl J Med"},{"key":"R15-20260422","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.3390\/biom11091316","article-title":"Combination of stem cells and rehabilitation therapies for ischemic stroke","volume":"11","author":"Berlet","year":"2021","journal-title":"Biomolecules"},{"key":"R16-20260422","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000446404","article-title":"Paracrine mechanisms of intravenous bone marrow-derived mononuclear stem cells in chronic ischemic stroke","volume":"6","author":"Bhasin","year":"2016","journal-title":"Cerebrovasc Dis Extra"},{"key":"R17-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-030-11096-3_1","article-title":"Stem cells heterogeneity","volume":"1123","author":"Birbrair","year":"2019","journal-title":"Adv Exp Med Biol"},{"key":"R18-20260422","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s13287-018-0913-2","article-title":"Neural stem cell therapy for subacute and chronic ischemic stroke","volume":"9","author":"Boese","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"R19-20260422","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41593-020-00759-4","article-title":"Long-term self-renewing stem cells in the adult mouse hippocampus identified by intravital imaging","volume":"24","author":"Bottes","year":"2021","journal-title":"Nat Neurosci"},{"key":"R20-20260422","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.stem.2015.12.004","article-title":"To serve and protect: hydrogels to improve stem cell-based therapies","volume":"18","author":"Burdick","year":"2016","journal-title":"Cell Stem Cell"},{"key":"R21-20260422","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1371\/journal.pone.0000373","article-title":"Neurosphere-derived cells exert a neuroprotective action by changing the ischemic microenvironment","volume":"2","author":"Capone","year":"2007","journal-title":"PLoS One"},{"key":"R22-20260422","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/347762a0","article-title":"Proliferation and differentiation of neuronal stem cells regulated by nerve growth factor","volume":"347","author":"Cattaneo","year":"1990","journal-title":"Nature"},{"key":"R23-20260422","doi-asserted-by":"crossref","first-page":"1410732","DOI":"10.3389\/fcell.2024.1410732","article-title":"Research progress and challenges of stem cell therapy for ischemic stroke","volume":"12","author":"Cha","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"R24-20260422","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/sj.jcbfm.9600034","article-title":"Atorvastatin induction of VEGF and BDNF promotes brain plasticity after stroke in mice","volume":"25","author":"Chen","year":"2005","journal-title":"J Cereb Blood Flow Metab"},{"key":"R25-20260422","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3389\/fnhum.2014.00382","article-title":"Neurorestorative therapy for stroke","volume":"8","author":"Chen","year":"2014","journal-title":"Front Hum Neurosci"},{"key":"R26-20260422","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4103\/bc.bc_39_19","article-title":"Stem cell-based regenerative medicine for neurological disorders: a special tribute to Dr. Teng Ma","volume":"5","author":"Corey","year":"2019","journal-title":"Brain Circulation"},{"key":"R27-20260422","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/bc.bc_17_17","article-title":"Exogenous stem cells pioneer a biobridge to the advantage of host brain cells following stroke: new insights for clinical applications","volume":"3","author":"Crowley","year":"2017","journal-title":"Brain Circ"},{"key":"R28-20260422","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/WCO.0b013e328352ec45","article-title":"Neural stem cell transplantation in central nervous system disorders: from cell replacement to neuroprotection","volume":"25","author":"De Feo","year":"2012","journal-title":"Curr Opin Neurol"},{"key":"R29-20260422","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.nbd.2007.06.010","article-title":"Enhancement of neuroplasticity through upregulation of beta1-integrin in human umbilical cord-derived stromal cell implanted stroke model","volume":"27","author":"Ding","year":"2007","journal-title":"Neurobiol Dis"},{"key":"R30-20260422","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.5966\/sctm.2015-0078","article-title":"Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression","volume":"4","author":"Doeppner","year":"2015","journal-title":"Stem Cells Transl Med"},{"key":"R31-20260422","doi-asserted-by":"crossref","first-page":"409","DOI":"10.4103\/1673-5374.375344","article-title":"Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke","volume":"19","author":"Duan","year":"2024","journal-title":"Neural Regen Res"},{"key":"R32-20260422","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2016.03.056","article-title":"The role of Insulin-Like Growth Factor 1 (IGF-1) in brain development, maturation and neuroplasticity","volume":"325","author":"Dyer","year":"2016","journal-title":"Neuroscience"},{"key":"R33-20260422","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/00055735-200012000-00003","article-title":"Update on ischemic stroke","volume":"11","author":"Egan","year":"2000","journal-title":"Curr Opin Ophthalmol"},{"key":"R34-20260422","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1136\/jnnp.2004.054882","article-title":"A randomised phase II study of interleukin-1 receptor antagonist in acute stroke patients","volume":"76","author":"Emsley","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R35-20260422","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/jnr.20724","article-title":"Temporally specific proliferation events are induced in the hippocampus following acute focal injury","volume":"83","author":"Ernst","year":"2006","journal-title":"J Neurosci Res"},{"key":"R36-20260422","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.ceb.2008.09.008","article-title":"The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development","volume":"20","author":"Farkas","year":"2008","journal-title":"Curr Opin Cell Biol"},{"key":"R37-20260422","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1044-7431(03)00060-5","article-title":"Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes","volume":"23","author":"Filippov","year":"2003","journal-title":"Mol Cell Neurosci"},{"key":"R38-20260422","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.stem.2012.05.012","article-title":"Adult neural stem cells bridge their niche","volume":"10","author":"Fuentealba","year":"2012","journal-title":"Cell Stem Cell"},{"key":"R39-20260422","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbrc.2022.01.095","article-title":"Long noncoding RNA H19 mediates neural stem\/progenitor cells proliferation, differentiation and apoptosis through the p53 signaling pathway after ischemic stroke","volume":"597","author":"Gan","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"R40-20260422","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.bbi.2016.09.020","article-title":"Induced neural stem cells modulate microglia activation states via CXCL12\/CXCR4 signaling","volume":"59","author":"Gao","year":"2017","journal-title":"Brain Behav Immun"},{"key":"R41-20260422","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0317167100052173","article-title":"Enhancing recovery after stroke with noradrenergic pharmacotherapy: a new frontier?","volume":"27","author":"Gladstone","year":"2000","journal-title":"Can J Neurol Sci"},{"key":"R42-20260422","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuint.2018.08.009","article-title":"CXCR7+ and CXCR4+ stem cells and neuron specific enolase in acute ischemic stroke patients","volume":"120","author":"G\u00f3jska-Grymaj\u0142o","year":"2018","journal-title":"Neurochem Int"},{"key":"R43-20260422","doi-asserted-by":"crossref","first-page":"938","DOI":"10.4252\/wjsc.v12.i9.938","article-title":"Role of the CXCR4-SDF1-HMGB1 pathway in the directional migration of cells and regeneration of affected organs","volume":"12","author":"Haque","year":"2020","journal-title":"World J Stem Cells"},{"key":"R44-20260422","doi-asserted-by":"crossref","first-page":"e50444","DOI":"10.1371\/journal.pone.0050444","article-title":"Human neural progenitor cell engraftment increases neurogenesis and microglial recruitment in the brain of rats with stroke","volume":"7","author":"Hassani","year":"2012","journal-title":"PLoS One"},{"key":"R45-20260422","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.3727\/096368912X657936","article-title":"In vivo and in vitro characterization of the angiogenic effect of CTX0E03 human neural stem cells","volume":"22","author":"Hicks","year":"2013","journal-title":"Cell Transplantation"},{"key":"R46-20260422","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1161\/STROKEAHA.107.510982","article-title":"Functional integration of newly generated neurons into striatum after cerebral ischemia in the adult rat brain","volume":"39","author":"Hou","year":"2008","journal-title":"Stroke"},{"key":"R47-20260422","doi-asserted-by":"crossref","first-page":"647","DOI":"10.14336\/AD.2021.1121","article-title":"VEGF, a key factor for blood brain barrier injury after cerebral ischemic stroke","volume":"13","author":"Hu","year":"2022","journal-title":"Aging Dis"},{"key":"R48-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2018.05.004","article-title":"Neural stem cell therapies and hypoxic-ischemic brain injury","volume":"173","author":"Huang","year":"2019","journal-title":"Prog Neurobiol"},{"key":"R49-20260422","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.4103\/1673-5374.387970","article-title":"Functional near-infrared spectroscopy in non-invasive neuromodulation","volume":"19","author":"Huo","year":"2024","journal-title":"Neural Regen Res"},{"key":"R50-20260422","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.neuron.2011.05.004","article-title":"Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain","volume":"70","author":"Ihrie","year":"2011","journal-title":"Neuron"},{"key":"R51-20260422","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1038\/jcbfm.2015.95","article-title":"Is forebrain neurogenesis a potential repair mechanism after stroke?","volume":"35","author":"Inta","year":"2015","journal-title":"J Cereb Blood Flow Metab"},{"key":"R52-20260422","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/jnr.20246","article-title":"Human neural stem\/progenitor cells, expanded in long-term neurosphere culture, promote functional recovery after focal ischemia in Mongolian gerbils","volume":"78","author":"Ishibashi","year":"2004","journal-title":"J Neurosci Res"},{"key":"R53-20260422","doi-asserted-by":"crossref","first-page":"111916","DOI":"10.1016\/j.matdes.2023.111916","article-title":"The potential of hydrogels as a niche for promoting neurogenesis and regulating neuroinflammation in ischemic stroke","volume":"229","author":"Jiang","year":"2023","journal-title":"Mater Design"},{"key":"R54-20260422","first-page":"jnnp","article-title":"Phase 1 study of safety and preliminary efficacy of intranasal transplantation of human neural stem cells (ANGE-S003) in Parkinson\u2019s disease","volume":"9","author":"Jiang","year":"2024","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R55-20260422","first-page":"80","article-title":"Neuroregeneration and functional recovery after stroke: advancing neural stem cell therapy toward clinical application","volume":"16","author":"Jiao","year":"2020","journal-title":"Neural Regen Res"},{"key":"R56-20260422","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nn.3980","article-title":"Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex","volume":"18","author":"Johnson","year":"2015","journal-title":"Nat Neurosci"},{"key":"R57-20260422","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/S0140-6736(16)30513-X","article-title":"Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study","volume":"388","author":"Kalladka","year":"2016","journal-title":"Lancet"},{"key":"R58-20260422","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/sctm.19-0229","article-title":"Translating intracarotid artery transplantation of bone marrow\u2010derived NCS\u201001 cells for ischemic stroke: Behavioral and histological readouts and mechanistic insights into stem cell therapy","volume":"9","author":"Kaneko","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"R59-20260422","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/1471-2202-11-146","article-title":"Contribution of constitutively proliferating precursor cell subtypes to dentate neurogenesis after cortical infarcts","volume":"11","author":"Keiner","year":"2010","journal-title":"BMC Neurosci"},{"key":"R60-20260422","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/386493a0","article-title":"More hippocampal neurons in adult mice living in an enriched environment","volume":"386","author":"Kempermann","year":"1997","journal-title":"Nature"},{"key":"R61-20260422","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.tins.2004.05.013","article-title":"Milestones of neuronal development in the adult hippocampus","volume":"27","author":"Kempermann","year":"2004","journal-title":"Trends Neurosci"},{"key":"R62-20260422","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuroscience.2014.09.074","article-title":"Early immature neuronal death initiates cerebral ischemia-induced neurogenesis in the dentate gyrus","volume":"284","author":"Kim","year":"2015","journal-title":"Neuroscience"},{"key":"R63-20260422","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1016\/j.cell.2024.05.030","article-title":"TNF-NF-\u03baB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons","volume":"187","author":"Kim","year":"2024","journal-title":"Cell"},{"key":"R64-20260422","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/stem.306","article-title":"Subventricular zone-derived neural progenitor cells migrate along a blood vessel scaffold toward the post-stroke striatum","volume":"28","author":"Kojima","year":"2010","journal-title":"Stem Cells"},{"key":"R65-20260422","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1212\/WNL.55.4.565","article-title":"Transplantation of cultured human neuronal cells for patients with stroke","volume":"55","author":"Kondziolka","year":"2000","journal-title":"Neurology"},{"key":"R66-20260422","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1146\/annurev.neuro.051508.135600","article-title":"The glial nature of embryonic and adult neural stem cells","volume":"32","author":"Kriegstein","year":"2009","journal-title":"Ann Rev Neurosci"},{"key":"R67-20260422","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.10945","article-title":"Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli","volume":"467","author":"Kronenberg","year":"2003","journal-title":"J Comp Neurol"},{"key":"R68-20260422","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1179\/174313209X383312","article-title":"Temporal profile of neurogenesis in the subventricular zone, dentate gyrus and cerebral cortex following transient focal cerebral ischemia","volume":"31","author":"Kuge","year":"2009","journal-title":"Neurol Res"},{"key":"R69-20260422","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1242\/dev.069963","article-title":"Transcriptional co-regulation of neuronal migration and laminar identity in the neocortex","volume":"139","author":"Kwan","year":"2012","journal-title":"Development (Cambridge, England)"},{"key":"R70-20260422","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.scr.2009.12.003","article-title":"Exosome secreted by MSC reduces myocardial ischemia\/reperfusion injury","volume":"4","author":"Lai","year":"2010","journal-title":"Stem Cell Res"},{"key":"R71-20260422","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1523\/JNEUROSCI.5360-06.2007","article-title":"Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain","volume":"27","author":"Lalancette-H\u00e9bert","year":"2007","journal-title":"J Neurosci"},{"key":"R72-20260422","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1126\/science.aag3048","article-title":"Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging","volume":"359","author":"Leeman","year":"2018","journal-title":"Science"},{"key":"R73-20260422","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neulet.2008.02.031","article-title":"Beta-catenin siRNA inhibits ischemia-induced striatal neurogenesis in adult rat brain following a transient middle cerebral artery occlusion","volume":"435","author":"Lei","year":"2008","journal-title":"Neurosci Lett"},{"key":"R74-20260422","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neures.2009.06.004","article-title":"Mechanisms, locations, and kinetics of synaptic BDNF secretion: an update","volume":"65","author":"Lessmann","year":"2009","journal-title":"Neurosci Res"},{"key":"R75-20260422","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1479-5876-8-63","article-title":"Adipose-derived mesenchymal stem cells markedly attenuate brain infarct size and improve neurological function in rats","volume":"8","author":"Leu","year":"2010","journal-title":"J Transl Med"},{"key":"R76-20260422","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cns.12343","article-title":"Cystamine improves functional recovery via axon remodeling and neuroprotection after stroke in mice","volume":"21","author":"Li","year":"2015","journal-title":"CNS Neurosci Ther"},{"key":"R77-20260422","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/j.2769-2795.2021.tb00066.x","article-title":"Research progress of IGF-1 and cerebral ischemia","volume":"7","author":"Li","year":"2021","journal-title":"Ibrain"},{"key":"R78-20260422","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1002\/dneu.20674","article-title":"Enhanced neurogenesis and cell migration following focal ischemia and peripheral stimulation in mice","volume":"68","author":"Li","year":"2008","journal-title":"Dev Neurobiol"},{"key":"R79-20260422","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.59.4.514","article-title":"Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery","volume":"59","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"R80-20260422","doi-asserted-by":"crossref","first-page":"781","DOI":"10.4103\/1673-5374.382229","article-title":"Succinylation modification: a potential therapeutic target in stroke","volume":"19","author":"Lian","year":"2024","journal-title":"Neural Regen Res"},{"key":"R81-20260422","doi-asserted-by":"crossref","first-page":"678","DOI":"10.2174\/1574888X18666230505103407","article-title":"Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the therapeutic of ischemic stroke","volume":"19","author":"Liao","year":"2024","journal-title":"Curr Stem Cell Res Ther"},{"key":"R82-20260422","doi-asserted-by":"crossref","first-page":"a018820","DOI":"10.1101\/cshperspect.a018820","article-title":"The adult ventricular-subventricular zone (V-SVZ) and olfactory bulb (OB) neurogenesis","volume":"8","author":"Lim","year":"2016","journal-title":"Cold Spring Harbor Perspect Biolo"},{"key":"R83-20260422","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0896-6273(00)00148-3","article-title":"Noggin antagonizes BMP signaling to create a niche for adult neurogenesis","volume":"28","author":"Lim","year":"2000","journal-title":"Neuron"},{"key":"R84-20260422","first-page":"173","article-title":"Biobridge concept in stem cell therapy for ischemic stroke","volume":"61","author":"Liska","year":"2017","journal-title":"J Neurosurg Sci"},{"key":"R85-20260422","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/j.cell.2023.02.017","article-title":"Purification and characterization of human neural stem and progenitor cells","volume":"186","author":"Liu","year":"2023","journal-title":"Cell"},{"key":"R86-20260422","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1523\/JNEUROSCI.18-19-07768.1998","article-title":"Increased neurogenesis in the dentate gyrus after transient global ischemia in gerbils","volume":"18","author":"Liu","year":"1998","journal-title":"J Neurosci"},{"key":"R87-20260422","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1097\/JS9.0000000000001791","article-title":"Stereotactically intracerebral transplantation of neural stem cells for ischemic stroke attenuated inflammatory responses and promoted neurogenesis: an experimental study with monkeys","volume":"110","author":"Liu","year":"2024","journal-title":"Int J Surg"},{"key":"R88-20260422","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2015.07.002","article-title":"Single-cell transcriptomics reveals a population of dormant neural stem cells that become activated upon brain injury","volume":"17","author":"Llorens-Bobadilla","year":"2015","journal-title":"Cell Stem Cell"},{"key":"R89-20260422","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1126\/science.8178174","article-title":"Long-distance neuronal migration in the adult mammalian brain","volume":"264","author":"Lois","year":"1994","journal-title":"Science"},{"key":"R90-20260422","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.cell.2015.04.001","article-title":"Single-cell transcriptome analyses reveal signals to activate dormant neural stem cells","volume":"161","author":"Luo","year":"2015","journal-title":"Cell"},{"key":"R91-20260422","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mcn.2012.02.003","article-title":"Mcl-1 regulates the survival of adult neural precursor cells","volume":"49","author":"Malone","year":"2012","journal-title":"Mol Cell Neurosci"},{"key":"R92-20260422","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1212\/WNL.0b013e3181cbccec","article-title":"Proliferation in the human ipsilateral subventricular zone after ischemic stroke","volume":"74","author":"Mart\u00ed-F\u00e0bregas","year":"2010","journal-title":"Neurology"},{"key":"R93-20260422","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nn.3610","article-title":"Adult neural stem cells in distinct microdomains generate previously unknown interneuron types","volume":"17","author":"Merkle","year":"2014","journal-title":"Nat Neurosci"},{"key":"R94-20260422","doi-asserted-by":"crossref","first-page":"107805","DOI":"10.1016\/j.celrep.2020.107805","article-title":"Single-cell profiling and SCOPE-seq reveal lineage dynamics of adult ventricular-subventricular zone neurogenesis and NOTUM as a key regulator","volume":"31","author":"Mizrak","year":"2020","journal-title":"Cell Rep"},{"key":"R95-20260422","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s12975-018-0668-1","article-title":"Application of mesenchymal stem cell-derived extracellular vesicles for stroke: biodistribution and microRNA Study","volume":"10","author":"Moon","year":"2019","journal-title":"Transl Stroke Res"},{"key":"R96-20260422","doi-asserted-by":"crossref","first-page":"8543","DOI":"10.3390\/ijms22168543","article-title":"Repair mechanisms of the neurovascular unit after ischemic stroke with a focus on VEGF","volume":"22","author":"Moon","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R97-20260422","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1159\/000525822","article-title":"Treatments in ischemic stroke: current and future","volume":"85","author":"Mosconi","year":"2022","journal-title":"Eur Neurol"},{"key":"R98-20260422","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12868-022-00732-w","article-title":"Therapeutic potential of hair follicle-derived stem cell intranasal transplantation in a rat model of ischemic stroke","volume":"23","author":"Mousavi","year":"2022","journal-title":"BMC Neurosci"},{"key":"R99-20260422","doi-asserted-by":"crossref","first-page":"109904","DOI":"10.1016\/j.msec.2019.109904","article-title":"Blended alginate\/collagen hydrogels promote neurogenesis and neuronal maturation","volume":"104","author":"Moxon","year":"2019","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"R100-20260422","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1136\/jnnp-2019-322515","article-title":"Intracerebral implantation of human neural stem cells and motor recovery after stroke: multicentre prospective single-arm study (PISCES-2)","volume":"91","author":"Muir","year":"2020","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R101-20260422","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1460-9568.2009.07043.x","article-title":"Injury-induced neural stem\/progenitor cells in post-stroke human cerebral cortex","volume":"31","author":"Nakayama","year":"2010","journal-title":"Eur J Neurosci"},{"key":"R102-20260422","doi-asserted-by":"crossref","first-page":"1800113","DOI":"10.1002\/adbi.201800113","article-title":"Shear containment of BDNF within molecular hydrogels promotes human stem cell engraftment and postinfarction remodeling in stroke","volume":"2","author":"Nisbet","year":"2018","journal-title":"Adv Biosystems"},{"key":"R103-20260422","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/STROKEAHA.112.660977","article-title":"Aberrant neurogenesis after stroke: a retroviral cell labeling study","volume":"43","author":"Niv","year":"2012","journal-title":"Stroke"},{"key":"R104-20260422","doi-asserted-by":"crossref","first-page":"13007","DOI":"10.1523\/JNEUROSCI.4323-06.2006","article-title":"A neurovascular niche for neurogenesis after stroke","volume":"26","author":"Ohab","year":"2006","journal-title":"J Neurosci"},{"key":"R105-20260422","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nn.2473","article-title":"Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells","volume":"13","author":"Ohira","year":"2010","journal-title":"Nat Neurosci"},{"key":"R106-20260422","doi-asserted-by":"crossref","first-page":"991","DOI":"10.2147\/DDDT.S460998","article-title":"Revolutionizing stroke recovery: unveiling the promise of stem cell therapy","volume":"18","author":"Panos","year":"2024","journal-title":"Drug Design Dev Ther"},{"key":"R107-20260422","doi-asserted-by":"crossref","first-page":"3727","DOI":"10.1523\/JNEUROSCI.17-10-03727.1997","article-title":"Dentate granule cell neurogenesis is increased by seizures and contributes to aberrant network reorganization in the adult rat hippocampus","volume":"17","author":"Parent","year":"1997","journal-title":"J Neurosci"},{"key":"R108-20260422","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/nbt751","article-title":"The injured brain interacts reciprocally with neural stem cells supported by scaffolds to reconstitute lost tissue","volume":"20","author":"Park","year":"2002","journal-title":"Nat Biotechnol"},{"key":"R109-20260422","doi-asserted-by":"crossref","first-page":"748949","DOI":"10.3389\/fmedt.2022.748949","article-title":"Detection, diagnosis and treatment of acute ischemic stroke: current and future perspectives","volume":"4","author":"Patil","year":"2022","journal-title":"Front Med Technol"},{"key":"R110-20260422","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.it.2007.05.007","article-title":"The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis","volume":"28","author":"Petit","year":"2007","journal-title":"Trends Immunol"},{"key":"R111-20260422","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0166-2236(03)00169-3","article-title":"The stem-cell menagerie","volume":"26","author":"Pevny","year":"2003","journal-title":"Trends Neurosci"},{"key":"R112-20260422","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.expneurol.2005.12.011","article-title":"A conditionally immortal clonal stem cell line from human cortical neuroepithelium for the treatment of ischemic stroke","volume":"199","author":"Pollock","year":"2006","journal-title":"Exp Neurol"},{"key":"R113-20260422","doi-asserted-by":"crossref","first-page":"111991","DOI":"10.1016\/j.colsurfb.2021.111991","article-title":"Hydrogels: a potential platform for induced pluripotent stem cell culture and differentiation","volume":"207","author":"Poorna","year":"2021","journal-title":"Colloids Surf B Biointerfaces"},{"key":"R114-20260422","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.actbio.2014.12.017","article-title":"Effects of mesenchymal stem cell therapy, in association with pharmacologically active microcarriers releasing VEGF, in an ischaemic stroke model in the rat","volume":"15","author":"Quittet","year":"2015","journal-title":"Acta Biomater"},{"key":"R115-20260422","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature17040","article-title":"Angiocrine functions of organ-specific endothelial cells","volume":"529","author":"Rafii","year":"2016","journal-title":"Nature"},{"key":"R116-20260422","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1186\/s40001-024-01987-1","article-title":"Stem cell therapies for neurological disorders: current progress, challenges, and future perspectives","volume":"29","author":"Rahimi Darehbagh","year":"2024","journal-title":"Eur J Med Res"},{"key":"R117-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12975-020-00841-w","article-title":"Neurogenesis after stroke: a therapeutic perspective","volume":"12","author":"Rahman","year":"2021","journal-title":"Transl Stroke Res"},{"key":"R118-20260422","doi-asserted-by":"crossref","first-page":"117400","DOI":"10.1016\/j.jep.2023.117400","article-title":"Periplaneta Americana (L.) extract activates the ERK\/CREB\/BDNF pathway to promote post-stroke neuroregeneration and recovery of neurological functions in rats","volume":"321","author":"Rao","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"R119-20260422","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fneur.2016.00041","article-title":"High-resolution microfluidic single-cell transcriptional profiling reveals clinically relevant subtypes among human stem cell populations commonly utilized in cell-based therapies","volume":"7","author":"Rennert","year":"2016","journal-title":"Front Neurol"},{"key":"R120-20260422","doi-asserted-by":"crossref","first-page":"e1571","DOI":"10.1002\/term.2582","article-title":"Using minimalist self-assembling peptides as hierarchical scaffolds to stabilise growth factors and promote stem cell integration in the injured brain","volume":"12","author":"Rodriguez","year":"2018","journal-title":"J Tissue Eng Regen Med"},{"key":"R121-20260422","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000348705","article-title":"Thrombolytics in acute ischaemic stroke: historical perspective and future opportunities","volume":"35","author":"R\u00f6ther","year":"2013","journal-title":"Cerebrovasc Dis"},{"key":"R122-20260422","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.brainres.2015.02.042","article-title":"Coupling of neurogenesis and angiogenesis after ischemic stroke","volume":"1623","author":"Ruan","year":"2015","journal-title":"Brain Res"},{"key":"R123-20260422","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0369-18.2018","article-title":"Exogenous neural precursor cell transplantation results in structural and functional recovery in a hypoxic-ischemic hemiplegic mouse model","volume":"5","author":"Rumajogee","year":"2018","journal-title":"eNeuro"},{"key":"R124-20260422","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1186\/s12967-022-03610-5","article-title":"Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications","volume":"20","author":"Rust","year":"2022","journal-title":"J Transl Med"},{"key":"R125-20260422","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/10738584221110100","article-title":"Stem cell therapy for repair of the injured brain: five principles","volume":"30","author":"Rust","year":"2024","journal-title":"Neuroscientist"},{"key":"R126-20260422","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/jbm.b.34252","article-title":"Biohybrids of scaffolding hyaluronic acid biomaterials plus adipose stem cells home local neural stem and endothelial cells: Implications for reconstruction of brain lesions after stroke","volume":"107","author":"Sanchez-Rojas","year":"2019","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"R127-20260422","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1161\/STROKEAHA.106.477331","article-title":"Intravenous brain-derived neurotrophic factor enhances poststroke sensorimotor recovery and stimulates neurogenesis","volume":"38","author":"Sch\u00e4bitz","year":"2007","journal-title":"Stroke"},{"key":"R128-20260422","doi-asserted-by":"crossref","first-page":"145","DOI":"10.4196\/kjpp.2018.22.2.145","article-title":"Toll-like receptor 2 promotes neurogenesis from the dentate gyrus after photothrombotic cerebral ischemia in mice","volume":"22","author":"Seong","year":"2018","journal-title":"Korean J Physiol Pharmacol"},{"key":"R129-20260422","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1523\/JNEUROSCI.21-18-07153.2001","article-title":"Astrocytes give rise to new neurons in the adult mammalian hippocampus","volume":"21","author":"Seri","year":"2001","journal-title":"J Neurosci"},{"key":"R130-20260422","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.stem.2015.07.013","article-title":"Single-cell RNA-seq with waterfall reveals molecular cascades underlying adult neurogenesis","volume":"17","author":"Shin","year":"2015","journal-title":"Cell Stem Cell"},{"key":"R131-20260422","doi-asserted-by":"crossref","first-page":"14951","DOI":"10.1038\/s41598-018-33030-9","article-title":"Transplantation of a bone marrow mesenchymal stem cell line increases neuronal progenitor cell migration in a cerebral ischemia animal model","volume":"8","author":"Shiota","year":"2018","journal-title":"Sci Rep"},{"key":"R132-20260422","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1016\/j.celrep.2017.07.069","article-title":"Peptide-based scaffolds support human cortical progenitor graft integration to reduce atrophy and promote functional repair in a model of stroke","volume":"20","author":"Somaa","year":"2017","journal-title":"Cell Rep"},{"key":"R133-20260422","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.3727\/096368912X657909","article-title":"Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice","volume":"22","author":"Song","year":"2013","journal-title":"Cell Transplant"},{"key":"R134-20260422","doi-asserted-by":"crossref","first-page":"19565","DOI":"10.1038\/s41598-019-56021-w","article-title":"Controlling properties of human neural progenitor cells using 2D and 3D conductive polymer scaffolds","volume":"9","author":"Song","year":"2019","journal-title":"Sci Rep"},{"key":"R135-20260422","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1177\/1545968309335978","article-title":"The neural stem cell line CTX0E03 promotes behavioral recovery and endogenous neurogenesis after experimental stroke in a dose-dependent fashion","volume":"23","author":"Stroemer","year":"2009","journal-title":"Neurorehabil Neural Repair"},{"key":"R136-20260422","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13578-021-00541-4","article-title":"Time-course single-cell RNA sequencing reveals transcriptional dynamics and heterogeneity of limbal stem cells derived from human pluripotent stem cells","volume":"11","author":"Sun","year":"2021","journal-title":"Cell Biosci"},{"key":"R137-20260422","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1186\/s13287-021-02575-4","article-title":"Salvianolic acid-B improves fat graft survival by promoting proliferation and adipogenesis","volume":"12","author":"Sun","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"R138-20260422","doi-asserted-by":"crossref","first-page":"e74857","DOI":"10.1371\/journal.pone.0074857","article-title":"Stem cell recruitment of newly formed host cells via a successful seduction? Filling the gap between neurogenic niche and injured brain site","volume":"8","author":"Tajiri","year":"2013","journal-title":"PLoS One"},{"key":"R139-20260422","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3389\/fnsys.2014.00116","article-title":"Stem cell-paved biobridge facilitates neural repair in traumatic brain injury","volume":"8","author":"Tajiri","year":"2014","journal-title":"Front Syst Neurosci"},{"key":"R140-20260422","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","article-title":"Induction of pluripotent stem cells from adult human fibroblasts by defined factors","volume":"131","author":"Takahashi","year":"2007","journal-title":"Cell"},{"key":"R141-20260422","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"R142-20260422","doi-asserted-by":"crossref","first-page":"e013583","DOI":"10.1161\/JAHA.119.013583","article-title":"Activated mesenchymal stem cells induce recovery following stroke via regulation of inflammation and oligodendrogenesis","volume":"9","author":"Tobin","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"R143-20260422","doi-asserted-by":"crossref","first-page":"8386","DOI":"10.3390\/ijms24098386","article-title":"Molecular mechanisms underlying pluripotency and self-renewal of embryonic stem cells","volume":"24","author":"Varzideh","year":"2023","journal-title":"Int J Mol Sci"},{"key":"R144-20260422","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1007\/s12031-019-01460-3","article-title":"Intra-arterial stem cell therapy diminishes inflammasome activation after ischemic stroke: a possible role of acid sensing ion channel 1a","volume":"71","author":"Vats","year":"2021","journal-title":"J Mol Neurosci"},{"key":"R145-20260422","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1177\/0271678X18782789","article-title":"Exosome-mediated amplification of endogenous brain repair mechanisms and brain and systemic organ interaction in modulating neurological outcome after stroke","volume":"38","author":"Venkat","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"R146-20260422","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1161\/CIR.0000000000000950","article-title":"Heart disease and stroke statistics\u20142021 update","volume":"143","author":"Virani","year":"2021","journal-title":"Circulation"},{"key":"R147-20260422","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1089\/scd.2009.0188","article-title":"Direct intrathecal implantation of mesenchymal stromal cells leads to enhanced neuroprotection via an NFkappaB-mediated increase in interleukin-6 production","volume":"19","author":"Walker","year":"2010","journal-title":"Stem Cells Dev"},{"key":"R148-20260422","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1177\/0963689718795424","article-title":"Transplanting mesenchymal stem cells for treatment of ischemic stroke","volume":"27","author":"Wang","year":"2018","journal-title":"Cell Transplant"},{"key":"R149-20260422","doi-asserted-by":"crossref","first-page":"6217","DOI":"10.1007\/s11033-020-05569-2","article-title":"The role of exosomes in stroke","volume":"47","author":"Wang","year":"2020","journal-title":"Mol Biol Rep"},{"key":"R150-20260422","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.cmi.2018.03.026","article-title":"Genome engineering of clostridium difficile using the CRISPR-Cas9 system","volume":"24","author":"Wang","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"R151-20260422","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.4103\/1673-5374.390968","article-title":"Application of artificial hibernation technology in acute brain injury","volume":"19","author":"Wang","year":"2024","journal-title":"Neural Regen Res"},{"key":"R152-20260422","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41467-023-36133-8","article-title":"Hydrogel oxygen reservoirs increase functional integration of neural stem cell grafts by meeting metabolic demands","volume":"14","author":"Wang","year":"2023","journal-title":"Nat Commun"},{"key":"R153-20260422","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1177\/0271678X17702669","article-title":"Neuroprotective and regenerative roles of intranasal Wnt-3a administration after focal ischemic stroke in mice","volume":"38","author":"Wei","year":"2018","journal-title":"J Cereb Blood Flow Metab"},{"key":"R154-20260422","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/185117a0","article-title":"Hydrophilic gels for biological use","volume":"185","author":"Wichterle","year":"1960","journal-title":"Nature"},{"key":"R155-20260422","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/acsnano.1c00672","article-title":"Embryonic stem cell derived small extracellular vesicles modulate regulatory t cells to protect against ischemic stroke","volume":"15","author":"Xia","year":"2021","journal-title":"ACS Nano"},{"key":"R156-20260422","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.wneu.2020.02.010","article-title":"Adult Neurogenesis following ischemic stroke and implications for cell-based therapeutic approaches","volume":"138","author":"Xie","year":"2020","journal-title":"World Neurosurg"},{"key":"R157-20260422","doi-asserted-by":"crossref","first-page":"31448","DOI":"10.1073\/pnas.2014389117","article-title":"High-resolution mouse subventricular zone stem-cell niche transcriptome reveals features of lineage, anatomy, and aging","volume":"117","author":"Xie","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R158-20260422","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.stem.2020.08.014","article-title":"Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function","volume":"28","author":"Xiong","year":"2021","journal-title":"Cell Stem Cell"},{"key":"R159-20260422","doi-asserted-by":"crossref","first-page":"131","DOI":"10.31083\/j.jin2307131","article-title":"Therapeutic strategies for ischemic stroke: modulating the adult neural stem cell niche through the Wnt\/\u03b2-catenin pathway","volume":"23","author":"Xu","year":"2024","journal-title":"J Integr Neurosci"},{"key":"R160-20260422","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.stem.2020.09.014","article-title":"Pluripotent stem cell-based cell therapy-promise and challenges","volume":"27","author":"Yamanaka","year":"2020","journal-title":"Cell Stem Cell"},{"key":"R161-20260422","doi-asserted-by":"crossref","first-page":"6627","DOI":"10.1523\/JNEUROSCI.0149-06.2006","article-title":"Subventricular zone-derived neuroblasts migrate and differentiate into mature neurons in the post-stroke adult striatum","volume":"26","author":"Yamashita","year":"2006","journal-title":"J Neurosci"},{"key":"R162-20260422","doi-asserted-by":"crossref","first-page":"105740","DOI":"10.1016\/j.clineuro.2020.105740","article-title":"Research trends of stem cells in ischemic stroke from 1999 to 2018: a bibliometric analysis","volume":"192","author":"Yang","year":"2020","journal-title":"Clin Neurol Neurosurg"},{"key":"R163-20260422","doi-asserted-by":"crossref","first-page":"147197","DOI":"10.1016\/j.brainres.2020.147197","article-title":"Curcumin promotes neurogenesis of hippocampal dentate gyrus via Wnt\/\u03b2-catenin signal pathway following cerebral ischemia in mice","volume":"1751","author":"Yang","year":"2021","journal-title":"Brain Res"},{"key":"R164-20260422","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2021.03.026","article-title":"Hydrogels for large-scale expansion of stem cells","volume":"128","author":"Yin","year":"2021","journal-title":"Acta Biomater"},{"key":"R165-20260422","doi-asserted-by":"crossref","first-page":"601600","DOI":"10.3389\/fcell.2021.601600","article-title":"Neural stem cell-derived exosomes regulate neural stem cell differentiation through miR-9-hes1 axis","volume":"9","author":"Yuan","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"R166-20260422","doi-asserted-by":"crossref","first-page":"774","DOI":"10.4103\/1673-5374.382224","article-title":"Versatile strategies for adult neurogenesis: avenues to repair the injured brain","volume":"19","author":"Zhao","year":"2024","journal-title":"Neural Regen Res"},{"key":"R167-20260422","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/sctm.18-0220","article-title":"Stable intracerebral transplantation of neural stem cells for the treatment of paralysis due to ischemic stroke","volume":"8","author":"Zhang","year":"2019","journal-title":"Stem Cells Transl Med"},{"key":"R168-20260422","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/ons\/opz204","article-title":"First human trial of stem cell transplantation in complex arrays for stroke patients using the intracerebral microinjection instrument","volume":"18","author":"Zhang","year":"2020","journal-title":"Oper Neurosurg"},{"key":"R169-20260422","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jare.2020.05.017","article-title":"Exosomes derived from human neural stem cells stimulated by interferon gamma improve therapeutic ability in ischemic stroke model","volume":"24","author":"Zhang","year":"2020","journal-title":"J Adv Res"},{"key":"R170-20260422","first-page":"727542","article-title":"Molecular biomarkers for embryonic and adult neural stem cell and neurogenesis","volume":"2015","author":"Zhang","year":"2015","journal-title":"BioMed Res Int"},{"key":"R171-20260422","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2004.09.061","article-title":"Expression of insulin-like growth factor 1 and receptor in ischemic rats treated with human marrow stromal cells","volume":"1030","author":"Zhang","year":"2004","journal-title":"Brain Res"},{"key":"R172-20260422","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/s12967-016-0979-5","article-title":"Sodium ferulate and n-butylidenephthalate combined with bone marrow stromal cells (BMSCs) improve the therapeutic effects of angiogenesis and neurogenesis after rat focal cerebral ischemia","volume":"14","author":"Zhang","year":"2016","journal-title":"J Transl Med"},{"key":"R173-20260422","doi-asserted-by":"crossref","first-page":"e84493","DOI":"10.7554\/eLife.84493","article-title":"NSC-derived exosomes enhance therapeutic effects of NSC transplantation on cerebral ischemia in mice","volume":"12","author":"Zhang","year":"2023","journal-title":"eLife"},{"key":"R174-20260422","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1038\/jcbfm.2009.55","article-title":"Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse","volume":"29","author":"Zhang","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"R175-20260422","doi-asserted-by":"crossref","first-page":"286","DOI":"10.5853\/jos.2019.03048","article-title":"Optimizing stem cell therapy after ischemic brain injury","volume":"22","author":"Zhang","year":"2020","journal-title":"J Stroke"},{"key":"R176-20260422","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuint.2017.09.001","article-title":"Salvianolic acids for injection (SAFI) promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice","volume":"110","author":"Zhang","year":"2017","journal-title":"Neurochem Int"},{"key":"R177-20260422","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/aps.2018.23","article-title":"Pharmacological approaches promoting stem cell-based therapy following ischemic stroke insults","volume":"39","author":"Zhu","year":"2018","journal-title":"Acta Pharmacol Sinica"},{"key":"R178-20260422","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.2147\/IJN.S451642","article-title":"Neural stem cell-derived small extracellular vesicles: key players in ischemic stroke therapy - a comprehensive literature review","volume":"19","author":"Zhu","year":"2024","journal-title":"Int J Nanomed"},{"key":"R179-20260422","doi-asserted-by":"crossref","first-page":"404","DOI":"10.4103\/1673-5374.346466","article-title":"Neural stem cell-derived exosome as a nano-sized carrier for BDNF delivery to a rat model of ischemic stroke","volume":"18","author":"Zhu","year":"2023","journal-title":"Neural Regen Res"},{"key":"R180-20260422","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1016\/j.celrep.2018.11.003","article-title":"Single-cell transcriptomics characterizes cell types in the subventricular zone and uncovers molecular defects impairing adult neurogenesis","volume":"25","author":"Zywitza","year":"2018","journal-title":"Cell Rep"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00879","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:01Z","timestamp":1787837101000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-00879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,13]]},"references-count":180,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-00879","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,13]]},"assertion":[{"value":"2024-08-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-26","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}