{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:33:07Z","timestamp":1792085587588,"version":"4.4.0"},"reference-count":196,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Neuronal plasticity, the brain\u2019s ability to adapt structurally and functionally, is essential for learning, memory, and recovery from injuries. In neurodegenerative diseases such as Alzheimer\u2019s disease and Parkinson\u2019s disease, this plasticity is disrupted, leading to cognitive and motor deficits. This review explores the mechanisms of neuronal plasticity and its effect on Alzheimer\u2019s disease and Parkinson\u2019s disease. Alzheimer\u2019s disease features amyloid-beta plaques and tau tangles that impair synaptic function, while Parkinson\u2019s disease involves the loss of dopaminergic neurons affecting motor control. Enhancing neuronal plasticity offers therapeutic potential for these diseases. A systematic literature review was conducted using databases such as PubMed, Scopus, and Google Scholar, focusing on studies of neuronal plasticity in Alzheimer\u2019s disease and Parkinson\u2019s disease. Data synthesis identified key themes such as synaptic mechanisms, neurogenesis, and therapeutic strategies, linking molecular insights to clinical applications. Results highlight that targeting synaptic plasticity mechanisms, such as long-term potentiation and long-term depression, shows promise. Neurotrophic factors, advanced imaging techniques, and molecular tools (e.g., clustered regularly interspaced short palindromic repeats and optogenetics) are crucial in understanding and enhancing plasticity. Current therapies, including dopamine replacement, deep brain stimulation, and lifestyle interventions, demonstrate the potential to alleviate symptoms and improve outcomes. In conclusion, enhancing neuronal plasticity through targeted therapies holds significant promise for treating neurodegenerative diseases. Future research should integrate multidisciplinary approaches to fully harness the therapeutic potential of neuronal plasticity in Alzheimer\u2019s disease and Parkinson\u2019s disease.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-01019","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T11:04:01Z","timestamp":1734433441000},"page":"107-125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":27,"title":["Neuronal plasticity and its role in Alzheimer\u2019s disease and Parkinson\u2019s disease"],"prefix":"10.4103","volume":"21","author":[{"given":"Israt","family":"Jahan","sequence":"first","affiliation":[{"name":"Genetic Engineering and Biotechnology Research Laboratory (GEBRL), Centre for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-4620","authenticated-orcid":false,"given":"Mohammad","family":"Harun-Ur-Rashid","sequence":"additional","affiliation":[{"name":"Department of Chemistry, International University of Business Agriculture and Technology (IUBAT), Sector 10, Uttara Model Town, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Aminul","family":"Islam","sequence":"additional","affiliation":[{"name":"Genetic Engineering and Biotechnology Research Laboratory (GEBRL), Centre for Advanced Research in Sciences (CARS), University of Dhaka, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhana","family":"Sharmin","sequence":"additional","affiliation":[{"name":"Department of Anatomy, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soad K.","family":"Al Jaouni","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology, Yousef Abdulatif Jameel Scientific Chair of Prophetic Medicine Application, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah M.","family":"Kaki","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Medicine, Director of Pain Clinic, Faculty of 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