{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T03:23:12Z","timestamp":1793848992176,"version":"4.6.1"},"reference-count":67,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0 http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202606000-00071\/figure1\/v\/2026-04-16T195327Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Multiple sclerosis is a severe autoimmune disorder that is mainly mediated by pathogenic cluster of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell subsets. Despite advancements in the management of multiple sclerosis, there is a critical need for more effective and safer treatments. In the present study, we administered\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide to a mouse model of experimental autoimmune encephalomyelitis\u2014an animal model of multiple sclerosis\u2014and evaluated its effects on pathogenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation both\n                    <jats:italic toggle=\"yes\">in vivo<\/jats:italic>\n                    and\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    .\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide significantly mitigated the clinical severity of experimental autoimmune encephalomyelitis, as demonstrated by reduced demyelination and neuroinflammation. Moreover,\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide treatment decreased the infiltration of peripheral leukocytes into the central nervous system and suppressed pro-inflammatory cytokine expression.\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide also modulated pathogenic CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell activation by inhibiting T helper 1\/T helper 17 cell differentiation while promoting regulatory T cell expansion. Notably, no side effects were observed, suggesting the long-term safety and tolerability of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide. Furthermore, RNA sequencing data indicated that\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide inhibits activator protein-1, an essential regulator of T cell activation and differentiation. This finding was supported by the reversal of T helper\/T helper 17 cell response suppression upon AP-1 blockade. Collectively, these results highlight the potential of\n                    <jats:italic toggle=\"yes\">Lycium barbarum<\/jats:italic>\n                    glycopeptide as an innovative therapeutic agent for CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cell-associated autoimmune or inflammatory diseases, such as multiple sclerosis.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-01093","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:11:45Z","timestamp":1743120705000},"page":"2563-2572","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Lycium barbarum polysaccharide on the activation of pathogenic CD4+ T cells in a mouse model of multiple sclerosis"],"prefix":"10.4103","volume":"21","author":[{"given":"Mengdi","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhen","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linglin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zilin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0384-8958","authenticated-orcid":false,"given":"Weiyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Ling","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Science and Technology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7996-7246","authenticated-orcid":false,"given":"Cun-Jin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sichuan Provincial People\u2019s Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"R1-20260416","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2019.10.015","article-title":"Pharmacological activation of pyruvate kinase M2 inhibits CD4(+) T cell pathogenicity and suppresses autoimmunity","volume":"31","author":"Angiari","year":"2020","journal-title":"Cell 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