{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:07:47Z","timestamp":1792624067749,"version":"4.5.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","license":[{"start":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T00:00:00Z","timestamp":1750291200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0 http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.4103\/nrr.nrr-d-24-01273","type":"journal-article","created":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T15:00:24Z","timestamp":1750345224000},"page":"3178-3186","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis"],"prefix":"10.4103","volume":"21","author":[{"given":"Mengyan","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"},{"name":"Guangdong Provincial Key Laboratory of Brain Function and Disease, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotong","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shisi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiruo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huipeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liling","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2118-0368","authenticated-orcid":false,"given":"Zhengqi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3175-7833","authenticated-orcid":false,"given":"Sanxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mental and Neurological Disease Research Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,19]]},"reference":[{"key":"R1-20260416","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.immuni.2019.01.002","article-title":"A neutrophil timer coordinates immune defense and vascular protection","volume":"50","author":"Adrover","year":"2019","journal-title":"Immunity"},{"key":"R2-20260416","doi-asserted-by":"crossref","first-page":"2002944","DOI":"10.1002\/advs.202002944","article-title":"Mesenchymal stem cells for neurological disorders","volume":"8","author":"Andrzejewska","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"R3-20260416","doi-asserted-by":"crossref","first-page":"6614","DOI":"10.1016\/j.cell.2024.08.029","article-title":"Intercellular nanotube-mediated mitochondrial transfer enhances T cell metabolic fitness and antitumor efficacy","volume":"187","author":"Baldwin","year":"2024","journal-title":"Cell"},{"key":"R4-20260416","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.2174\/0929867325666180111101410","article-title":"Mesenchymal stem cell therapy in intracerebral haemorrhagic stroke","volume":"25","author":"Bedini","year":"2018","journal-title":"Curr Med Chem"},{"key":"R5-20260416","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/cns.13378","article-title":"Mesenchymal stem cell therapy alleviates the neuroinflammation associated with acquired brain injury","volume":"26","author":"Bonsack","year":"2020","journal-title":"CNS Neurosci Ther"},{"key":"R6-20260416","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1212\/WNL.0000000000002175","article-title":"Cerebral amyloid angiopathy and cognitive outcomes in community-based older persons","volume":"85","author":"Boyle","year":"2015","journal-title":"Neurology"},{"key":"R7-20260416","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12975-019-00694-y","article-title":"Functional dynamics of neutrophils after ischemic stroke","volume":"11","author":"Cai","year":"2020","journal-title":"Transl Stroke Res"},{"key":"R8-20260416","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/15548627.2019.1630223","article-title":"Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells","volume":"16","author":"Ceccariglia","year":"2019","journal-title":"Autophagy"},{"key":"R9-20260416","doi-asserted-by":"crossref","first-page":"8129","DOI":"10.7150\/thno.62069","article-title":"Mesenchymal stem cell-derived extracellular vesicles ameliorate Alzheimer\u2019s disease-like phenotypes in a preclinical mouse model","volume":"11","author":"Cone","year":"2021","journal-title":"Theranostics"},{"key":"R10-20260416","doi-asserted-by":"crossref","first-page":"120866","DOI":"10.1016\/j.jns.2023.120866","article-title":"Exploring cerebral amyloid angiopathy: Insights into pathogenesis, diagnosis, and treatment","volume":"454","author":"Cozza","year":"2023","journal-title":"J Neurol Sci"},{"key":"R11-20260416","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J Biol Chem"},{"key":"R12-20260416","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.3390\/cells11223603","article-title":"Mitochondria transfer in brain injury and disease","volume":"11","author":"Fairley","year":"2022","journal-title":"Cells"},{"key":"R13-20260416","first-page":"16","article-title":"Mesenchymal stem cell secretome and extracellular vesicles for neurodegenerative diseases: Risk-benefit profile and next steps for the market access","volume":"29","author":"Giovannelli","year":"2023","journal-title":"Bioact Mater"},{"key":"R14-20260416","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41582-019-0281-2","article-title":"Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways","volume":"16","author":"Greenberg","year":"2020","journal-title":"Nat Rev Neurol"},{"key":"R15-20260416","doi-asserted-by":"crossref","first-page":"7834421","DOI":"10.1155\/2021\/7834421","article-title":"Mesenchymal stem cell therapy for Alzheimer\u2019s disease","volume":"2021","author":"Hern\u00e1ndez","year":"2021","journal-title":"Stem Cells Int"},{"key":"R16-20260416","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1038\/s41467-023-39693-x","article-title":"Macrophage lineage cells-derived migrasomes activate complement-dependent blood-brain barrier damage in cerebral amyloid angiopathy mouse model","volume":"14","author":"Hu","year":"2023","journal-title":"Nat Commun"},{"key":"R17-20260416","article-title":"Bone marrow mesenchymal stem cells protect against cerebral amyloid angiopathy by enhancing neutrophil mitocytosis","author":"Hu","year":"2025","journal-title":"Neural Regen Res"},{"key":"R18-20260416","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13024-023-00640-5","article-title":"Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer\u2019s disease","volume":"18","author":"Inoue","year":"2023","journal-title":"Mol Neurodegener"},{"key":"R19-20260416","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1002\/stem.2372","article-title":"Mitochondrial transfer via tunneling nanotubes is an important mechanism by which mesenchymal stem cells enhance macrophage phagocytosis in the in vitro and in vivo models of ARDS","volume":"34","author":"Jackson","year":"2016","journal-title":"Stem Cells"},{"key":"R20-20260416","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/alz.12366","article-title":"Prevalence of cerebral amyloid angiopathy: A systematic review and meta-analysis","volume":"18","author":"J\u00e4kel","year":"2022","journal-title":"Alzheimers Dement"},{"key":"R21-20260416","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12964-023-01121-4","article-title":"Migrasomes, a new mode of intercellular communication","volume":"21","author":"Jiang","year":"2023","journal-title":"Cell Commun Signal"},{"key":"R22-20260416","doi-asserted-by":"crossref","first-page":"2896","DOI":"10.1016\/j.cell.2021.04.027","article-title":"Mitocytosis, a migrasome-mediated mitochondrial quality-control process","volume":"184","author":"Jiao","year":"2021","journal-title":"Cell"},{"key":"R23-20260416","doi-asserted-by":"crossref","first-page":"119942","DOI":"10.1016\/j.biomaterials.2020.119942","article-title":"Mesenchymal stem cell-derived magnetic extracellular nanovesicles for targeting and treatment of ischemic stroke","volume":"243","author":"Kim","year":"2020","journal-title":"Biomaterials"},{"key":"R24-20260416","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/1747493020974464","article-title":"A practical approach to the management of cerebral amyloid angiopathy","volume":"16","author":"Kozberg","year":"2021","journal-title":"Int J Stroke"},{"key":"R25-20260416","doi-asserted-by":"crossref","first-page":"2206432","DOI":"10.1002\/advs.202206432","article-title":"Bone marrow mesenchymal stem cell\u2010derived dermcidin\u2010containing migrasomes enhance LC3\u2010associated phagocytosis of pulmonary macrophages and protect against post\u2010stroke pneumonia","volume":"10","author":"Li","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"R26-20260416","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/s12951-023-01828-z","article-title":"Comparative study of extracellular vesicles derived from mesenchymal stem cells and brain endothelial cells attenuating blood-brain barrier permeability via regulating Caveolin-1-dependent ZO-1 and Claudin-5 endocytosis in acute ischemic stroke","volume":"21","author":"Li","year":"2023","journal-title":"J Nanobiotechnology"},{"key":"R27-20260416","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.jconrel.2023.01.059","article-title":"Mechanisms behind therapeutic potentials of mesenchymal stem cell mitochondria transfer\/delivery","volume":"354","author":"Malekpour","year":"2023","journal-title":"J Control Release"},{"key":"R29-20260416","doi-asserted-by":"crossref","first-page":"16513","DOI":"10.1073\/pnas.1821601116","article-title":"STAT6 induces expression of Gas6 in macrophages to clear apoptotic neutrophils and resolve inflammation","volume":"116","author":"Nepal","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-20260416","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat Rev Immunol"},{"key":"R31-20260416","doi-asserted-by":"crossref","first-page":"e3000410","DOI":"10.1371\/journal.pbio.3000410","article-title":"The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol"},{"key":"R32-20260416","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s13287-022-02765-8","article-title":"The functional mechanism of bone marrow-derived mesenchymal stem cells in the treatment of animal models with Alzheimer\u2019s disease: crosstalk between autophagy and apoptosis","volume":"13","author":"Qin","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"R33-20260416","article-title":"Therapeutic mechanisms of umbilical cord mesenchymal stem cell-derived exosomes in ischemic stroke: A transcriptomic and metabolomic study","author":"Shen","year":"2025","journal-title":"Neural Regen Res"},{"key":"R34-20260416","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-pharmtox-010716-104908","article-title":"Repairing mitochondrial dysfunction in disease","volume":"58","author":"Sorrentino","year":"2018","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R35-20260416","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1161\/ATVBAHA.122.318559","article-title":"Hypoxia-preconditioned bone marrow mesenchymal stem cells improved cerebral collateral circulation and stroke outcome in mice","volume":"43","author":"Tian","year":"2023","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R36-20260416","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2019.02.028","article-title":"Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage","volume":"177","author":"Uderhardt","year":"2019","journal-title":"Cell"},{"key":"R37-20260416","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13024-023-00660-1","article-title":"Border-associated macrophages promote cerebral amyloid angiopathy and cognitive impairment through vascular oxidative stress","volume":"18","author":"Uekawa","year":"2023","journal-title":"Mol Neurodegener"},{"key":"R38-20260416","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5853\/jos.2023.01942","article-title":"Cerebral amyloid angiopathy: an undeniable small vessel disease","volume":"26","author":"Wang","year":"2024","journal-title":"J Stroke"},{"key":"R39-20260416","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.stem.2022.10.001","article-title":"Reciprocal regulation of mesenchymal stem cells and immune responses","volume":"29","author":"Wang","year":"2022","journal-title":"Cell Stem Cell"},{"key":"R40-20260416","doi-asserted-by":"crossref","first-page":"e2207107","DOI":"10.1002\/adma.202207107","article-title":"Engineered extracellular vesicles with SHP2 high expression promote mitophagy for Alzheimer\u2019s disease treatment","volume":"34","author":"Xu","year":"2022","journal-title":"Adv Mater"},{"key":"R41-20260416","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/s13287-024-03879-x","article-title":"Mesenchymal stem cell-derived extracellular vesicles mitigate neuronal damage from intracerebral hemorrhage by modulating ferroptosis","volume":"15","author":"Yang","year":"2024","journal-title":"Stem Cell Res Ther"},{"key":"R42-20260416","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.1111\/febs.16183","article-title":"Migrasome biogenesis and functions","volume":"289","author":"Yu","year":"2022","journal-title":"FEBS J"},{"key":"R43-20260416","article-title":"Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer\u2019s disease","author":"Zhang","year":"2025","journal-title":"Neural Regen Res"},{"key":"R44-20260416","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1021\/acsnano.0c08947","article-title":"Mesenchymal stem cell-derived extracellular vesicles attenuate mitochondrial damage and inflammation by stabilizing mitochondrial DNA","volume":"15","author":"Zhao","year":"2021","journal-title":"ACS Nano"},{"key":"R45-20260416","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1161\/STROKEAHA.123.045194","article-title":"Clearance of neutrophils from ICH-affected brain by macrophages is beneficial and is assisted by lactoferrin and CD91","volume":"55","author":"Zhao","year":"2024","journal-title":"Stroke"},{"key":"R46-20260416","first-page":"48","article-title":"TGF-\u03b21 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson\u2019s disease models and patients","volume":"11","author":"Zhuo","year":"2024","journal-title":"Mil Med Res"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-01273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:56Z","timestamp":1787837156000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-01273"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,19]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-01273","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,19]]},"assertion":[{"value":"2024-10-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}