{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:36Z","timestamp":1787840316003,"version":"build-2784847793"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.4103\/nrr.nrr-d-24-01308","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T00:09:22Z","timestamp":1743120562000},"page":"1134-1135","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Illusion of inactivity: Revisiting progressive multiple sclerosis treatment paradigms"],"prefix":"10.4103","volume":"21","author":[{"given":"Tal","family":"Ganz","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (Ganz T, Ben-Hur T)"},{"name":"The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah \u2013 Hebrew University Medical Center, Jerusalem, Israel (Ganz T, Ben-Hur T)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3463-2922","authenticated-orcid":false,"given":"Tamir","family":"Ben-Hur","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel (Ganz T, Ben-Hur T)"},{"name":"The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah \u2013 Hebrew University Medical Center, Jerusalem, Israel (Ganz T, Ben-Hur T)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fneur.2018.00181","article-title":"Evaluation of microglial activation in multiple sclerosis patients using positron emission tomography","volume":"9","author":"Airas","year":"2018","journal-title":"Front Neurol"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1212\/WNL.0000000000012323","article-title":"Secondary progressive multiple sclerosis: new insights","volume":"97","author":"Cree","year":"2021","journal-title":"Neurology"},{"key":"R3-20260422","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00401-016-1636-z","article-title":"Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging","volume":"133","author":"Dal-Bianco","year":"2017","journal-title":"Acta Neuropathol"},{"key":"R4-20260422","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1002\/glia.24453","article-title":"Oligodendrocyte progenitor cells differentiation induction with MAPK\/ERK inhibitor fails to support repair processes in the chronically demyelinated CNS","volume":"71","author":"Ganz","year":"2023","journal-title":"Glia"},{"key":"R5-20260422","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bbi.2024.08.032","article-title":"Targeting CNS myeloid infiltrates provides neuroprotection in a progressive multiple sclerosis model","volume":"122","author":"Ganz","year":"2024","journal-title":"Brain Behav Immun"},{"key":"R6-20260422","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12974-022-02408-y","article-title":"Central nervous system macrophages in progressive multiple sclerosis: relationship to neurodegeneration and therapeutics","volume":"19","author":"Kamma","year":"2022","journal-title":"J Neuroinflammation"},{"key":"R7-20260422","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.3389\/fimmu.2018.03116","article-title":"Pathogenic mechanisms associated with different clinical courses of multiple sclerosis","volume":"9","author":"Lassmann","year":"2019","journal-title":"Front Immunol"},{"key":"R8-20260422","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41582-019-0240-y","article-title":"Chronic inflammation in multiple sclerosis - seeing what was always there","volume":"15","author":"Matthews","year":"2019","journal-title":"Nat Rev Neurol"},{"key":"R9-20260422","doi-asserted-by":"crossref","DOI":"10.1002\/wsbm.1583","article-title":"Neurodegeneration in multiple sclerosis","author":"Mey","year":"2023","journal-title":"WIREs Mech Dis"},{"key":"R10-20260422","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.jconrel.2023.10.052","article-title":"Innovative drug delivery strategies to the CNS for the treatment of multiple sclerosis","volume":"364","author":"Mwema","year":"2023","journal-title":"J Control Release"},{"key":"R11-20260422","doi-asserted-by":"crossref","first-page":"577582","DOI":"10.1016\/j.jneuroim.2021.577582","article-title":"Modeling compartmentalized chronic immune-mediated demyelinating CNS disease in the Biozzi ABH mouse","volume":"356","author":"Nishri","year":"2021","journal-title":"J Neuroimmunol"},{"key":"R12-20260422","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1016\/j.neuron.2022.06.023","article-title":"Microglia in multiple sclerosis: protectors turn destroyers","volume":"110","author":"Yong","year":"2022","journal-title":"Neuron"}],"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-01308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:11Z","timestamp":1787836811000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRR-D-24-01308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/nrr.nrr-d-24-01308","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3,25]]},"assertion":[{"value":"2024-10-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}