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More importantly, mitochondria have been considered prominent mediators of the interplay between the gut microbiota and the brain. Intestinal microbes may modulate mitochondrial function in the central nervous system to affect the progression of neurodegenerative diseases. Mitochondria are essential for meeting the host\u2019s substantial neuronal metabolic demands, maintaining excitability, and facilitating synaptic transmission. Dysfunctional mitochondria are considered critical hallmarks of various neurodegenerative diseases. Therefore, this review provides novel insights into the intricate roles of gut microbiota-mitochondrial crosstalk in the underlying mechanisms during the progression of neurodegeneration, as well as the existing potential therapeutic strategies for neurodegenerative disorders. These suggest intestinal microbiota-mitochondrial interaction play a crucial role in the occurrence and development of neurodegenerative diseases, and targeting this interaction may be a promising therapeutic approach to neurodegenerative diseases. However, this review found that there was relatively little research on the effect of this crosstalk on other neurodegenerative diseases, such as Huntington\u2019s disease and Multiple sclerosis, and the potential therapeutic strategies were translated into clinical trials, which face many challenges in developing personalized treatment plans based on the unique gut microbiota of different individuals.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-01419","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:56:42Z","timestamp":1746172602000},"page":"2238-2253","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["The role of gut microbiota\u2013mitochondria crosstalk in neurodegeneration: Underlying mechanisms and potential therapies"],"prefix":"10.4103","volume":"21","author":[{"given":"Tianjuan","family":"Ju","sequence":"first","affiliation":[{"name":"State Key Laboratory of Oral & 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