{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:24Z","timestamp":1787775744235,"version":"build-2784847793"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:p>JOURNAL\/nrgr\/04.03\/01300535-202602000-00045\/figure1\/v\/2026-04-22T115157Z\/r\/image-tiff<\/jats:p>\n                  <jats:p>\n                    Neural stem cells (NSCs) have the potential for self-renewal and multidirectional differentiation, and their transplantation has achieved good efficacy in a variety of diseases. However, only 1%\u201310% of transplanted NSCs survive in the ischemic and hypoxic microenvironment of posthemorrhagic hydrocephalus. Sox2 is an important factor for NSCs to maintain proliferation. Therefore, Sox2-overexpressing NSCs (NSC\n                    <jats:sup>Sox2<\/jats:sup>\n                    ) may be more successful in improving neurological dysfunction after posthemorrhagic hydrocephalus. In this study, human NSC\n                    <jats:sup>Sox2<\/jats:sup>\n                    was transplanted into a posthemorrhagic hydrocephalus mouse model, and retinoic acid was administered to further promote NSC differentiation. The results showed that NSC\n                    <jats:sup>Sox2<\/jats:sup>\n                    attenuated the ventricular enlargement caused by posthemorrhagic hydrocephalus and improved neurological function. NSC\n                    <jats:sup>Sox2<\/jats:sup>\n                    also promoted nerve regeneration, inhibited neuroinflammation and promoted M2 polarization (anti-inflammatory phenotype), thereby reducing cerebrospinal fluid secretion in choroid plexus. These findings suggest that NSC\n                    <jats:sup>Sox2<\/jats:sup>\n                    rescued ventricular enlargement and neurological dysfunction induced by posthemorrhagic hydrocephalus through neural regeneration and modulation of inflammation.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrr-d-24-01491","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T11:01:55Z","timestamp":1746529315000},"page":"769-779","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Sox2-overexpressing neural stem cells alleviate ventricular enlargement and neurological dysfunction in posthemorrhagic hydrocephalus"],"prefix":"10.4103","volume":"21","author":[{"given":"Baocheng","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 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Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziang","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyou","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, West China Medical School, West China Hospital, Sichuan University, Chengdu, Sichuan Province, 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of China, Mianyang, Sichuan Province, China"},{"name":"Department of Neurosurgery, Fifth People\u2019s Hospital of Ningxia Hui Autonomous Region, Shizuishan, Ningxia Hui Autonomous Region, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,4,30]]},"reference":[{"key":"R1-20260422","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/s41591-022-01956-3","article-title":"Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: A phase 1\/2a trial","volume":"28","author":"Baloh","year":"2022","journal-title":"Nat Med"},{"key":"R2-20260422","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.stem.2019.02.004","article-title":"Mapping the global chromatin connectivity network for Sox2 function in neural stem cell maintenance","volume":"24","author":"Bertolini","year":"2019","journal-title":"Cell Stem 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