{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:33:10Z","timestamp":1786649590028,"version":"build-2736575974"},"reference-count":153,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0 http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:p>With the rapid development of life support technologies in the biomedical field, artificial hibernation has shown significant potential in the area of neural tissues and organ protection. This paper systematically reviews the three major technologies of artificial hibernation, as well as their operational procedures and the latest technological progress. It emphasizes the protective role of artificial hibernation technology on neural tissues and vital human organs, such as the brain, spinal cord, heart, kidneys, liver, and intestines, and explores its protective mechanisms. Based on an analysis of the existing literature, it was observed that artificial hibernation technology significantly lowers metabolic rate and decelerates pathological processes, consequently enhancing organ survival rates and functional recovery. This article explains the artificial hibernation technology, neural tissue and organs, and their relationships. By discussing the protective effects of the artificial hibernation technology on neural tissue and organs, it proves the therapeutic effects of this technology in diseases such as craniocerebral injury, extensive cerebral infarction, cerebral hemorrhage, neonatal hypoxic-ischemic encephalopathy and post-cardiopulmonary resuscitation encephalopathy. Furthermore, this paper addresses the clinical challenges associated with applying artificial hibernation for neuroprotection and organ preservation, while also outlining potential future development directions for the technology. Therefore, the exploration of how artificial hibernation technology protects neural tissue and organs provides a solid theoretical foundation for its future clinical application.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-25-00025","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T11:00:24Z","timestamp":1767092424000},"page":"4550-4559","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Artificial hibernation: A new technique for protecting neural tissue and organs"],"prefix":"10.4103","volume":"21","author":[{"given":"Wuhua","family":"Pang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of Chinese People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of Chinese People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-9802-4774","authenticated-orcid":false,"given":"Mengguang","family":"Wei","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of Chinese People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4551-0560","authenticated-orcid":false,"given":"Xiaoyin","family":"Li","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of Chinese People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0420-8349","authenticated-orcid":false,"given":"Xuyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Characteristic Medical Center of Chinese People\u2019s Armed Police Force, Tianjin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,12,30]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.3390\/antiox11112155","article-title":"Novel therapeutic approaches enhance pgc1-alpha to reduce oxidant stress-inflammatory signaling and improve functional recovery in hibernating myocardium","volume":"11","author":"Aggarwal","year":"2022","journal-title":"Antioxidants (Basel)"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3390\/cells12030414","article-title":"Therapeutic hypothermia after cardiac arrest attenuates hindlimb paralysis and damage of spinal motor neurons and astrocytes through modulating NRF2\/HO-1 signaling pathway in rats","volume":"12","author":"Ahn","year":"2023","journal-title":"Cells"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3390\/ijms19041023","article-title":"Preconditioning-like properties of short-term hypothermia in isolated perfused rat liver (IPRL) system","volume":"19","author":"Alva","year":"2018","journal-title":"Int J Mol Sci"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"fmaf009","DOI":"10.1093\/tropej\/fmaf009","article-title":"Fluid restriction for term infants with hypoxic-ischemic encephalopathy following perinatal asphyxia-a randomized controlled trial","volume":"71","author":"Ananthan","year":"2025","journal-title":"J Trop Pediatr"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"105830","DOI":"10.1016\/j.neubiorev.2024.105830","article-title":"The cerebellum and the mirror neuron system: a matter of inhibition? 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