{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:46:10Z","timestamp":1787071570120,"version":"build-2736575974"},"reference-count":155,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>The delta-opioid receptor was previously viewed as a mediator in pain regulation. Recent data shed light on its specific role in neural protection and regeneration. An up-regulation of delta-opioid receptor expression and\/or activity protects neuronal cells\/tissues against various injuries and promotes neural regeneration. This review focuses on these new findings and the underlying mechanisms. In particular, we summarize the following key points: (1) the role of delta-opioid receptor in neuroprotection across various models and conditions; (2) the mechanisms of delta-opioid receptor neuroprotection against acute injury; (3) the neuroprotective mechanisms of delta-opioid receptor during prolonged injury; (4) delta-opioid receptor protection against ischemic and degenerative brain diseases and the underlying mechanisms; and (5) the regulation of delta-opioid receptor in neural regeneration. This article aims to provide an overview of delta-opioid receptor-mediated neural protection and regeneration, as well as its potential in treating neurological diseases.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-25-00293","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:00:26Z","timestamp":1759140026000},"page":"3301-3310","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Delta-opioid receptor\u2013mediated neural protection and regeneration"],"prefix":"10.4103","volume":"21","author":[{"given":"Jiahui","family":"Li","sequence":"first","affiliation":[{"name":"Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, Fudan University, Shanghai, China"},{"name":"Shanghai Research Center for Acupuncture and Meridians, Shanghai, 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