{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T22:42:45Z","timestamp":1788043365070,"version":"build-2784847793"},"reference-count":188,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","license":[{"start":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T00:00:00Z","timestamp":1755043200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>An increasing amount of evidence shows that type I interferon response, which is induced by cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) and stimulator of interferon genes (STING) is closely associated with health and neuroinflammatory diseases. Abnormal activation or loss of control of the cGAS\u2013STING axis affects the development of neuroinflammation. Thus, we examined its role in major neurological diseases, including traumatic brain injury, Alzheimer\u2019s disease, Parkinson\u2019s disease, Huntington\u2019s disease, multiple sclerosis, herpes simplex encephalitis, and ataxia-telangiectasia. Additionally, targeted intervention of the cGAS\u2013STING axis to control neuroinflammation and treat related diseases has become the focus of current clinical research. This article describes the development of cGAS inhibitors and small molecules that target the cGAS\u2013STING axis and explores the potential applications of STING inhibitors and agonists in clinical research. In summary, the cGAS\u2013STING axis may impact neurological diseases more than a single protein or gene. Future studies should focus on elucidating the functional dynamics and regulatory networks of this axis and delineating its crosstalk with other signaling cascades. These investigations will provide mechanistic insights for developing targeted therapeutic strategies for associated disorders and potentially facilitate drug repurposing across diverse disease contexts.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-25-00367","type":"journal-article","created":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T08:00:19Z","timestamp":1755158419000},"page":"3285-3300","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["cGAS\u2013STING axis: A central regulator of neural homeostasis and neuroinflammatory pathogenesis"],"prefix":"10.4103","volume":"21","author":[{"given":"Jiajie","family":"Zhang","sequence":"first","affiliation":[{"name":"Graduate School of Hebei Medical University, Shijiazhuang, Hebei Province, China"},{"name":"Department of Anesthesiology, Hebei Children\u2019s Hospital, Shijiazhuang, Hebei Province, 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