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This review aims to investigate the role of the hippocampus in cognitive impairment following a stroke. A review of the literature suggests that the hippocampus is a metabolically active structure that is easily involved in various metabolic states, such as hypoxia and hypoglycaemia. The functional changes in hippocampal cells associated with poststroke cognitive impairment mainly manifest as neuronal apoptosis, impaired synaptic plasticity, and decreased neurogenesis. The primary pathological mechanism of poststroke cognitive impairment involves a complex cascade of reactions, including neuroinflammatory activation, bursts of oxidative stress, and neuronal apoptosis induced by mitochondrial dysfunction. Interventional drugs for cognitive impairment after cerebral ischemia include neuroprotective drugs, traditional Chinese medicines and their extracts, and stem cell therapies. Many of these drugs have unique advantages, including the inhibition of neuroinflammation, the prevention of apoptosis, and the promotion of neurogenesis. They hold great potential for the prevention and treatment of cognitive impairment following cerebral ischemia. However, most current studies are animal experiments, and relatively few clinical studies exist. In future research, emphasis should be placed on interventions for cognitive impairment following cerebral ischemia. These findings offer novel perspectives for the treatment of cognitive impairment after cerebral ischemia. Finally, the role of hippocampal cell dysfunction in other diseases associated with cognitive decline is briefly discussed. The aim of this review is to provide researchers with a comprehensive overview of the role of the hippocampus in cognitive impairment and its intervention strategies.<\/jats:p>","DOI":"10.4103\/nrr.nrr-d-25-00410","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:00:29Z","timestamp":1759140029000},"page":"3479-3495","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Dysfunction of hippocampal cells and its role in cognitive impairment"],"prefix":"10.4103","volume":"21","author":[{"given":"Jingwen","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaohuizi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liusuyu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengsiyuan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4863-2707","authenticated-orcid":false,"given":"Xia","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3669-5687","authenticated-orcid":false,"given":"Gang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Medical School of Nantong University, Nantong, Jiangsu Province, China"},{"name":"Key Laboratory of Neuroregeneration of Jiangsu Province and the Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University; 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