{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:37:18Z","timestamp":1792849038570,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/ http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Cerebral palsy secondary to hypoxic\u2013ischemic encephalopathy remains a leading cause of neonatal neurological disability with limited treatment options.\n                    <jats:italic toggle=\"yes\">Angong Niuhuang<\/jats:italic>\n                    Pill, a traditional Chinese medicine formulation, has demonstrated neuroprotective potential. However, its efficacy and mechanisms in cerebral palsy models remain underexplored. In this study, we evaluated the therapeutic effects of\n                    <jats:italic toggle=\"yes\">Angong Niuhuang<\/jats:italic>\n                    Pill in a neonatal rat model of hypoxia\/ischemia-induced cerebral palsy. Magnetic resonance imaging revealed significantly reduced infarct volume in\n                    <jats:italic toggle=\"yes\">Angong Niuhuang<\/jats:italic>\n                    Pill-treated animals compared with the vehicle group. Behavioral assessments showed improved negative geotaxis performance on day 14, as well as enhanced outcomes in foot fault and von Frey filament tests after day 42, indicating amelioration of motor deficits and sensory disturbances. Histological analysis revealed decreased microglial activation and reduced cell counts in the ipsilateral hemisphere. Transcriptomic sequencing and Western blot analyses confirmed the downregulation of pyroptosis-related molecules, including NOD-like receptor family pyrin domain-containing 3, gasdermin D, and the N-terminal fragment of gasdermin D (N-GSDMD), in the\n                    <jats:italic toggle=\"yes\">Angong Niuhuang<\/jats:italic>\n                    Pill group.\n                    <jats:italic toggle=\"yes\">Angong Niuhuang<\/jats:italic>\n                    Pill confers neuroprotection in a neonatal hypoxic-ischemic encephalopathy model of cerebral palsy by limiting infarct progression, attenuating neuroinflammation and pyroptosis, and improving long-term sensorimotor outcomes. Attenuation of the NLRP3 inflammasome pathway represents an important contributing mechanism underlying these beneficial effects.\n                  <\/jats:p>","DOI":"10.4103\/nrr.nrronline-d-26-00459","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:00:14Z","timestamp":1790874014000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Angong Niuhuang Pill mitigates hypoxia\/ischemia-induced impairments in neuromotor function and microglial activation in neonatal rats"],"prefix":"10.4103","author":[{"given":"Lu","family":"Tan","sequence":"first","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihong","family":"Lao","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Zhao","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zexiu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibo","family":"Qu","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2091-9263","authenticated-orcid":false,"given":"Shicong","family":"Wang","sequence":"additional","affiliation":[{"name":"Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development, Zhangzhou, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4039-4246","authenticated-orcid":false,"given":"Kwok-Fai","family":"So","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4174-0892","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Jinan University, Guangzhou, Guangdong Province, China"},{"name":"Research Center, Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,9,30]]},"container-title":["Neural Regeneration Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRRONLINE-D-26-00459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T13:00:20Z","timestamp":1792846820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/NRR.NRRONLINE-D-26-00459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/nrr.nrronline-d-26-00459","relation":{},"ISSN":["1673-5374","1876-7958"],"issn-type":[{"value":"1673-5374","type":"print"},{"value":"1876-7958","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-04-28","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}