{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:29Z","timestamp":1787772449132,"version":"build-2784847793"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Marfan\u2019s syndrome (MFS) is an autosomal dominant connective tissue disorder with defect in the fibrillin-1 gene. The most common ocular manifestation is subluxated lens in the superotemporal direction, accounting for 50%\u201385% of total cases. The association of lens coloboma with MFS has been described in literature, but the coexistence of lens coloboma with ectopia lentis is a rare feature. Here, we describe three cases of MFS including a case of bilateral lens coloboma with ectopia lentis: case 1 \u2013 a 39-year-old male with inferotemporal lens subluxation in the right eye and superotemporal lens subluxation in the left eye with open-angle glaucoma and high myopia, case 2 \u2013 a 15-year-old child with bilateral superonasal lens subluxation with lens coloboma, and case 3 \u2013 a 56-year-old female with bilateral lens coloboma. Case 1 and case 2 had clear lenses with good refractive correction; hence, they were optically rehabilitated with contact lenses, whereas case 3 was advised for cataract surgery. It is important to distinguish the lens coloboma from a more common entity, ectopia lentis as former usually remains stable while the latter might need a surgical intervention.<\/jats:p>","DOI":"10.4103\/ojo.ojo_108_22","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:56:24Z","timestamp":1716558984000},"page":"310-313","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Diverse presentations of ectopia lentis and lens coloboma in Marfan\u2019s syndrome"],"prefix":"10.4103","volume":"16","author":[{"given":"Richa","family":"Dhiman","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Government Medical College, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lovepreet","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan Lal","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Ambala, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/eye.2013.274","article-title":"Molecular pathogenesis and management strategies of ectopia lentis","volume":"28","author":"Chandra","year":"2014","journal-title":"Eye (Lond)"},{"key":"R2-20240908","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J Med Genet"},{"key":"R4-20240908","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archopht.121.4.585","article-title":"Lens dislocation in Marfan syndrome and UV-B light exposure","volume":"121","author":"Sachdev","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"R5-20240908","first-page":"201","article-title":"Bilateral coloboma of lens in Marfan's syndrome","volume":"33","author":"Mehrotra","year":"1985","journal-title":"Indian J Ophthalmol"},{"key":"R6-20240908","first-page":"21","article-title":"Coloboma of lens","volume":"32","author":"Angra","year":"1984","journal-title":"Indian J Ophthalmol"},{"key":"R7-20240908","doi-asserted-by":"crossref","first-page":"bcr2014207112","DOI":"10.1136\/bcr-2014-207112","article-title":"Lens coloboma in one eye and ectopia lentis in the other eye of a patient with Marfan syndrome","volume":"2014","author":"Thapa","year":"2014","journal-title":"BMJ Case Rep"},{"key":"R8-20240908","first-page":"Doc14","article-title":"Bilateral ectopia lentis with isolated lens coloboma in Marfan syndrome","volume":"6","author":"Sahu","year":"2016","journal-title":"GMS Ophthalmol Cases"},{"key":"R9-20240908","first-page":"87","article-title":"Case series of Ectopia Lentis associated with Marfan's syndrome","volume":"31","author":"Laad","year":"2020","journal-title":"Delhi J Ophthalmol"},{"key":"R10-20240908","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jcjo.2013.12.004","article-title":"Surgical outcomes of isolated lens coloboma with or without cataract among young adults","volume":"49","author":"Gurler","year":"2014","journal-title":"Can J Ophthalmol"},{"key":"R11-20240908","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/ICU.0b013e32835a939f","article-title":"Glued intraocular lens:A major review on surgical technique and results","volume":"24","author":"Kumar","year":"2013","journal-title":"Curr Opin Ophthalmol"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_108_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:47:22Z","timestamp":1787770042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_108_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_108_22","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-04-27","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-25","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}