{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:16Z","timestamp":1787772376995,"version":"build-2784847793"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Automated microkeratome is commonly used to get donor lenticules for Descemet stripping endothelial keratoplasty (DSEK); however, manual dissection of donor lenticules is also being done with good outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>AIM:<\/jats:title>\n                    <jats:p>The aim of this study was to describe the results of manual DSEK performed in cases of corneal endothelial dysfunction caused due to pseudophakic bullous keratopathy, iridocorneal endothelial syndrome, and postpenetrating keratoplasty graft failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>This was a retrospective observational study. The medical records of all patients with corneal decompensation who underwent DSEK at a tertiary care center performed by the same surgeon were reviewed. A standard DSEK with manually dissected donor lenticules was performed in all cases with the exception of the Descemet membrane not being removed in two cases. A comprehensive ophthalmic examination was performed preoperatively and at each postoperative visit in all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Eight eyes of seven patients (four males and three females) were included. The mean age was 64.8 years (range, 49\u201374 years). The average follow-up was 10.9 months (range, 5\u201322 months). There was one case of primary graft failure which was managed by repeat DSEK. In the rest, corneas remained clear at the last follow-up. No rebubbling was done as none of the cases showed graft detachment. The preoperative best-corrected visual acuity (BCVA) was 20\/2000 or less, and postoperatively, BCVA attained was 20\/30 in four eyes and one eye achieved 20\/80.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSIONS:<\/jats:title>\n                    <jats:p>Manual DSEK performed in eyes with corneal decompensation allowed rapid restoration of corneal clarity while minimizing intraoperative and postoperative complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_130_21","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:49:17Z","timestamp":1716558557000},"page":"337-341","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes of Descemet stripping endothelial keratoplasty in cases of corneal endothelial dysfunction"],"prefix":"10.4103","volume":"15","author":[{"given":"Dubbaka","family":"Srujana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabaratna","family":"Bista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohini","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20240908","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.ophtha.2007.01.001","article-title":"Keratoplasty for endothelial dysfunction","volume":"114","author":"Patel","year":"2007","journal-title":"Ophthalmology"},{"key":"R2-15-20240908","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1016\/j.ophtha.2009.06.021","article-title":"Descemet's stripping endothelial keratoplasty: Safety and outcomes: A report by the American academy of ophthalmology","volume":"116","author":"Lee","year":"2009","journal-title":"Ophthalmology"},{"key":"R3-15-20240908","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/01.ico.0000239002.92989.1a","article-title":"Posterior lamellar keratoplasty using descemetorhexis and organ-cultured donor corneal tissue (Melles technique)","volume":"25","author":"Nieuwendaal","year":"2006","journal-title":"Cornea"},{"key":"R4-15-20240908","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.ophtha.2012.12.036","article-title":"Immunologic graft rejection in descemet's stripping endothelial keratoplasty and penetrating keratoplasty for endothelial disease","volume":"120","author":"Ezon","year":"2013","journal-title":"Ophthalmology"},{"key":"R5-15-20240908","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ajo.2012.06.014","article-title":"Comparative cost-effectiveness analysis of descemet stripping automated endothelial keratoplasty versus penetrating keratoplasty in the United States","volume":"155","author":"Prabhu","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"R6-15-20240908","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1755-3768.2008.01492.x","article-title":"Descemet's stripping automated endothelial keratoplasty and penetrating keratoplasty for Fuchs' endothelial dystrophy","volume":"87","author":"Hjortdal","year":"2009","journal-title":"Acta Ophthalmol"},{"key":"R7-15-20240908","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4103\/0301-4738.116484","article-title":"Complications and management in descemet's stripping endothelial keratoplasty: Analysis of consecutive 430 cases","volume":"62","author":"Basak","year":"2014","journal-title":"Indian J Ophthalmol"},{"key":"R8-15-20240908","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.ophtha.2006.05.034","article-title":"Descemet's stripping with endothelial keratoplasty: Comparative outcomes with microkeratome-dissected and manually dissected donor tissue","volume":"113","author":"Price","year":"2006","journal-title":"Ophthalmology"},{"key":"R9-15-20240908","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.ico.0000214224.90743.01","article-title":"Descemet-stripping automated endothelial keratoplasty","volume":"25","author":"Gorovoy","year":"2006","journal-title":"Cornea"},{"key":"R10-15-20240908","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ophtha.2006.07.056","article-title":"Early results of small-incision descemet's stripping and automated endothelial keratoplasty","volume":"114","author":"Koenig","year":"2007","journal-title":"Ophthalmology"},{"key":"R11-15-20240908","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/01.ico.0000243958.07027.f2","article-title":"Histology of dislocations in endothelial keratoplasty (DSEK and DLEK): A laboratory-based, surgical solution to dislocation in 100 consecutive DSEK cases","volume":"25","author":"Terry","year":"2006","journal-title":"Cornea"},{"key":"R12-15-20240908","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jcrs.2005.12.078","article-title":"Descemet's stripping with endothelial keratoplasty in 200 eyes: Early challenges and techniques to enhance donor adherence","volume":"32","author":"Price","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"R13-15-20240908","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1097\/ICO.0b013e318180e58b","article-title":"Endothelial keratoplasty: Case selection in the learning curve","volume":"27","author":"O'Brien","year":"2008","journal-title":"Cornea"},{"key":"R14-15-20240908","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.ajo.2009.06.034","article-title":"Visually significant and non significant complications arising from descemet stripping automated endothelial keratoplasty","volume":"148","author":"Shih","year":"2009","journal-title":"Am J 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