{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:34Z","timestamp":1787070994449,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To analyze varying clinical presentations, histopathological features, and management outcome of sebaceous gland carcinoma (SGC) of the eyelid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>We retrospectively reviewed medical records of 30 patients with histologically proven cases of SGC of eyelid treated at tertiary care hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>Patients were in the age group of 28\u201380 years, among which 18 (60%) were females and 12 (40%) were males. Mean follow-up period was 29.83 \u00b1 8.14 months. Six out of 30 cases were lost to follow-up; hence, only 24 cases were analyzed for reconstruction techniques and management outcome. Initial anatomic sites involved were upper eyelid (10 cases [33.33%]), lower eyelid (5 cases [16.66%]), both upper and lower eyelid (10 cases [33.33%]), and medial canthus (1 case [3.33%]). Orbital extension at presentation was present in 4 cases (13.33%) while metastasis to preauricular lymph nodes was seen in 1 case (3.33%). T2 was the most common category according to TNM staging (14, 58.33%). Reconstruction techniques included direct closure with or without cantholysis in 5 (20.83%), closure with Tenzel's semicircular flap in 2 (8.33%), Cutler Beard repair in 5 (20.83%), and Hughes's flap with either cheek advancement flap or full-thickness skin graft in 3 (12.5%). Both upper eyelid and lower eyelid repair were done in three (12.5%) cases and medial canthal repair in one (4.16%) case. Five (20.83%) cases underwent exenteration. On histopathological examination, 23 (95.83%) patients had localized tumors while only 1 (4.16%) patient had pagetoid invasion. Recurrence was observed in three (12.5%) cases. One (4.16%) case died subsequent to brain metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>SGC of eyelid may have varied presentations, but early diagnosis and consequent surgical therapy has good outcome and higher survival rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_139_2017","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:37:32Z","timestamp":1716557852000},"page":"21-27","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Eyelid sebaceous gland carcinoma: Varied presentations and reconstruction outcome"],"prefix":"10.4103","volume":"11","author":[{"given":"Syed Ali","family":"Raza Rizvi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Al Nahdha Hospital, Ministry of Health, Muscat, Sultanate of Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahid","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Jawaharlal Nehru Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kafil","family":"Akhtar","sequence":"additional","affiliation":[{"name":"Department of Pathology, Jawaharlal Nehru Medical College, AMU, Aligarh, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20250925","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.survophthal.2004.12.008","article-title":"Sebaceous carcinoma of the ocular region: A review","volume":"50","author":"Shields","year":"2005","journal-title":"Surv Ophthalmol"},{"key":"R2-20250925","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/archopht.1956.00930040077010","article-title":"Meibomian gland tumors","volume":"56","author":"Straatsma","year":"1956","journal-title":"AMA Arch 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