{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:33Z","timestamp":1787772393454,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Cornea plana (CP) is a rare ocular condition existing in two distinct clinical and hereditary forms: a milder, autosomal dominant type I and a more severe, autosomal recessive type II. The condition is more commonly found in Finnish, Saudi, and Czech families. We report three brothers from a consanguineous marriage that presented with complaints of decreased vision of varying degrees. All three of them have blue, thick, and hazy corneas with shallow anterior chamber depths. The additional features of CP type II were seen in the older two brothers including arcus lipoids, ill-demarcated limbus, and an accommodative squint. They were managed by the correction of refractive errors through spectacles and detailed counseling with follow-up visits to look for progressive complications. The management is mainly centered around optically or surgically correcting the developmental anomalies. This is complimented with proper genetic counseling and regular follow-up visits to look for and manage complications. There are, however, novel therapies that can be considered in these patients including corneal transplants or corneal stromal stem cellular therapies.<\/jats:p>","DOI":"10.4103\/ojo.ojo_139_22","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:56:24Z","timestamp":1716558984000},"page":"305-309","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Cornea plana in a family from Pakistan: Case series and literature review on the principles of management"],"prefix":"10.4103","volume":"16","author":[{"given":"Taimoor Ashraf","family":"Khan","sequence":"first","affiliation":[{"name":"General Ophthalmology, Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheharyar","family":"Zameer","sequence":"additional","affiliation":[{"name":"General Surgery, Pak-Emirates Military Hospital, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teyyeb Azeem","family":"Janjua","sequence":"additional","affiliation":[{"name":"General Ophthalmology, Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Abdullah","family":"Zahid","sequence":"additional","affiliation":[{"name":"General Medicine, Monash Health, Victoria, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Akram","sequence":"additional","affiliation":[{"name":"General Ophthalmology, Armed Forces Institute of Ophthalmology, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naafiah Khalid","family":"Mallick","sequence":"additional","affiliation":[{"name":"General Surgery, Pak-Emirates Military Hospital, Rawalpindi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/75664","article-title":"Mutations in KERA, encoding keratocan, cause cornea Plana","volume":"25","author":"Pellegata","year":"2000","journal-title":"Nat Genet"},{"key":"R2-20240908","first-page":"4711","article-title":"Novel variants in the KERA gene cause autosomal recessive cornea Plana in a Chinese family:A case report","volume":"19","author":"Huang","year":"2019","journal-title":"Mol Med Rep"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1600-0420.1998.760215.x","article-title":"Autosomal recessive cornea Plana. A clinical and genetic study of 78 cases in Finland","volume":"76","author":"Forsius","year":"1998","journal-title":"Acta Ophthalmol Scand"},{"key":"R4-20240908","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1038\/s41467-018-03646-6","article-title":"Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases","volume":"9","author":"Iglesias","year":"2018","journal-title":"Nat Commun"},{"key":"R5-20240908","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1136\/bjo.86.7.815","article-title":"The surgical correction of moderate hypermetropia:The management controversy","volume":"86","author":"McGhee","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"R6-20240908","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/00003226-198802000-00003","article-title":"Comprehensive visual and cosmetic rehabilitation of cornea Plana","volume":"7","author":"Dada","year":"1988","journal-title":"Cornea"},{"key":"R7-20240908","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/ijo.IJO_1324_20","article-title":"Open-angle glaucoma in a case of cornea Plana with unilateral microcornea:A cloud on the Horizon","volume":"1","author":"Menon","year":"2021","journal-title":"Indian J Ophthalmol Case Rep"},{"key":"R8-20240908","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1097\/j.jcrs.0000000000000350","article-title":"Customized toric intraocular lens implantation in cornea Plana","volume":"46","author":"Fogla","year":"2020","journal-title":"J Cataract Refract Surg"},{"key":"R9-20240908","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40662-018-0122-1","article-title":"Cellular therapy of the corneal stroma:A new type of corneal surgery for keratoconus and corneal dystrophies","volume":"5","author":"Ali\u00f3Del Barrio","year":"2018","journal-title":"Eye Vis (Lond)"},{"key":"R10-20240908","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/IIO.0000000000000398","article-title":"A review of pediatric corneal transplants:Perioperative, operative, and postoperative management","volume":"62","author":"Park","year":"2022","journal-title":"Int Ophthalmol Clin"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_139_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:42:56Z","timestamp":1787769776000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_139_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_139_22","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2022-05-17","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}