{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:32:00Z","timestamp":1787070720442,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>Acute intraocular pressure (IOP) spike in acute primary angle closure (APAC) decreases ocular blood flow. It is not known if this is true in primary angle-closure (PAC) eyes without prior APAC who may have had subacute attacks. Hence, we aimed to assess the ocular perfusion using optical coherence tomography angiography (OCTA) characteristics in normal, PAC suspect (PACS), and PAC eyes without APAC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>This was a prospective cross-sectional study, which determined patients\u2019 (40\u201380 years) optic nerve peripapillary perfusion, flux, and macular vessel density (6 mm \u00d7 6 mm and 3 mm \u00d7 3 mm) in the superficial retinal layer on OCTA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      We included 135 eyes of 135 patients (45 per subgroup). The mean age was 59.7 \u00b1 8.3 years. The mean peripapillary perfusion was 44.4% \u00b11.5% in normal, 44.2% \u00b11.7% in PACS, and 44.1% \u00b11.5% in PAC eyes. There was no significant difference between OCTA parameters among normal, PACS, and PAC eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.75 \u2013 peripapillary perfusion, 0.92 \u2013 flux, 0.58 \u2013 6 \u00d7 6 and 0.09 \u2013 3 mm \u00d7 3 mm). The maximum recorded IOP was significantly correlated with retinal nerve fiber layer thickness in the PAC group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.045) but not correlated with the perfusion parameters in any subgroup. The mean deviation on Humphrey visual field was significantly worse in PAC eyes compared to PACS eyes (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Similar OCTA parameters were seen in normal, PACS, and PAC eyes without prior APAC, suggestive of absence of vascular factors in eyes without APAC in angle-closure disease. Functional impairment, despite similar structural and perfusion parameters in PAC eyes compared to PACS eyes, may be suggestive of ganglion cell dysfunction prior to loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_154_24","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T07:00:10Z","timestamp":1750748410000},"page":"133-137","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Ocular perfusion in primary angle-closure suspect and primary angle-closure eyes without prior acute angle closure"],"prefix":"10.4103","volume":"18","author":[{"given":"Reni","family":"Philip","sequence":"first","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venkateshwaran","family":"Kannan","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingam","family":"Vijaya","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashima","family":"Asokan","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shantha","family":"Balekudaru","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annadurai","family":"Parivadhini","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronnie","family":"George","sequence":"additional","affiliation":[{"name":"Smt Jadhavbai Nathmal Singhvi Glaucoma Services, Medical Research Foundation, Sankara Nethralaya, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"R1-20250628","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s00417-017-3593-1","article-title":"Peripapillary retinal vessel density in eyes with acute primary angle closure: An optical coherence tomography angiography 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coherence tomography angiography","volume":"11","author":"Lin","year":"2022","journal-title":"J Clin Med"},{"key":"R9-20250628","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S1350-9462(02)00008-3","article-title":"The impact of ocular blood flow in glaucoma","volume":"21","author":"Flammer","year":"2002","journal-title":"Prog Retin Eye Res"},{"key":"R10-20250628","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/jamaophthalmol.2017.0261","article-title":"Peripapillary retinal nerve fiber layer vascular microcirculation in eyes with glaucoma and single-hemifield visual field loss","volume":"135","author":"Chen","year":"2017","journal-title":"JAMA Ophthalmol"},{"key":"R11-20250628","doi-asserted-by":"crossref","first-page":"P30","DOI":"10.1016\/j.ophtha.2020.10.021","article-title":"Primary angle-closure disease preferred practice pattern\u00ae","volume":"128","author":"Gedde","year":"2021","journal-title":"Ophthalmology"},{"key":"R12-20250628","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.1038\/s41598-018-24520-x","article-title":"Optical coherence tomography angiography vessel density changes after acute intraocular pressure elevation","volume":"8","author":"Zhang","year":"2018","journal-title":"Sci Rep"},{"key":"R13-20250628","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12886-019-1146-6","article-title":"Changes in vessel density of the patients with narrow antenior chamber after an acute intraocular pressure elevation observed by OCT angiography","volume":"19","author":"Ma","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"R14-20250628","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/IAE.0000000000002433","article-title":"Acute macular and peripapillary angiographic changes with intravitreal injections","volume":"40","author":"Barash","year":"2020","journal-title":"Retina"},{"key":"R15-20250628","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1167\/iovs.16-20579","article-title":"Optical coherence tomography angiography analysis of the foveal avascular zone and macular vessel density after anti-VEGF therapy in eyes with diabetic macular edema and retinal vein occlusion","volume":"58","author":"Ghasemi Falavarjani","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Oman Journal of 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