{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:30:23Z","timestamp":1786728623826,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:p>Nocardia keratitis is mostly seen in patients with alcoholism, malnutrition, or HIV. Its chronic waxing-and-waning course makes it difficult to diagnose. A 53-year-old male presented with pain and redness in his right eye for the past 3 weeks. The cornea had paracentral ulcer with stromal infiltrates and multiple satellite lesions giving wreath-like appearance suggestive of Nocardia. After corneal scraping, fortified amikacin, moxifloxacin, and cycloplegics were started. Gram stain revealed filamentous, branching Gram-positive bacteria and acid-fast on Ziehl\u2013Neelsen stain confirming our clinical diagnosis. Ulcer completely resolved over 6 weeks. Thus, a high index of clinical suspicion which was further backed by microbiological confirmation aided in expedient management ensuring a successful outcome.<\/jats:p>","DOI":"10.4103\/ojo.ojo_175_23","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T01:01:28Z","timestamp":1719450088000},"page":"261-263","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Nocardia keratitis: A clinical diagnosis with successful outcome"],"prefix":"10.4103","volume":"17","author":[{"given":"Dubbaka","family":"Srujana","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Shankar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kavita Bala","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohini","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Military Hospital, Jalandhar, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanchal","family":"Singhal","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Base Hospital, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Kochhar","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Armed Forces Medical College, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"key":"R1-20260507","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/ICU.0b013e32832c3bcc","article-title":"Nocardia keratitis","volume":"20","author":"Lalitha","year":"2009","journal-title":"Curr Opin Ophthalmol"},{"key":"R2-20260507","first-page":"162","article-title":"Bilateral Nocardia keratitis after photorefractive keratectomy","volume":"7","author":"Faramarzi","year":"2012","journal-title":"J Ophthalmic Vis Res"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/j.ophtha.2010.10.037","article-title":"Optimizing diagnosis and management of Nocardia keratitis, scleritis, and endophthalmitis: 11-year microbial and clinical overview","volume":"118","author":"DeCroos","year":"2011","journal-title":"Ophthalmology"},{"key":"R4-20260507","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/eye.2011.332","article-title":"Fungal, mycobacterial, and Nocardia infections and the eye: An update","volume":"26","author":"Garg","year":"2012","journal-title":"Eye (Lond)"},{"key":"R5-20260507","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.jcrs.2008.08.045","article-title":"Outbreak of Nocardia keratitis after photorefractive keratectomy: Clinical, microbiological, histopathological, and confocal scan study","volume":"35","author":"Javadi","year":"2009","journal-title":"J Cataract Refract Surg"},{"key":"R6-20260507","first-page":"31","article-title":"Nocardia asteroides keratitis in South India","volume":"21","author":"Bharathi","year":"2003","journal-title":"Indian J Med Microbiol"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"211","DOI":"10.4103\/jms.jms_79_16","article-title":"Nocardia keratitis: A case report from tertiary care hospital of Punjab, India","volume":"31","author":"Sheemar","year":"2017","journal-title":"J Med Soc"},{"key":"R8-20260507","first-page":"173","article-title":"Efficacy of topical and systemic itraconazole as a broad-spectrum antifungal agent in mycotic corneal ulcer. A preliminary study","volume":"49","author":"Agarwal","year":"2001","journal-title":"Indian J Ophthalmol"},{"key":"R9-20260507","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1001\/archophthalmol.2011.315","article-title":"Corticosteroids for bacterial keratitis: The Steroids for Corneal Ulcers Trial (SCUT)","volume":"130","author":"Srinivasan","year":"2012","journal-title":"Arch Ophthalmol"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_175_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:29:29Z","timestamp":1786724969000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_175_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_175_23","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"2023-07-30","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-23","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}