{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:01Z","timestamp":1787775661075,"version":"build-2784847793"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n                  <jats:sec>\n                    <jats:title>PURPOSE:<\/jats:title>\n                    <jats:p>To analyze the outcomes of concurrent intravenous pulse steroids and orbital radiation (ORT) in thyroid eye disease (TED).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>It was a retrospective interventional study. Medical records of patients presenting with clinically or radiologically active TED with diplopia were reviewed. All patients received concurrent ORT (20 Gy in 10 fractions) and 500 mg of pulsed intravenous methylprednisolone (IVMP). The response to treatment was assessed using International Thyroid Eye Disease Society-Vision, Inflammation, Strabismus, and Appearance scoring system.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Forty-eight orbits of 24 patients were included in the study. There was an equal male and female (12 each) distribution. The mean age at presentation was 53.6 \u00b1 11.4 years (range: 38\u201373 years). The median duration of orbital disease was 5.5 months (range 1\u201396 months). Diplopia (22, 91.66%) was the most common presenting complaint. Posttreatment, there was a significant reduction in the mean inflammatory score (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Complete resolution of diplopia was seen in 82.6% (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0009) patients and a significant improvement in extraocular motility was seen in 95.8% of patients (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Prism glasses were prescribed in two patients for residual diplopia. The mean follow-up period was 20 \u00b1 16.506 months (median 19 months, range: 3\u201360 months). No significant complication was noted at the last follow-up in any of the patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Concurrent pulse IVMP with ORT is a safe and effective treatment modality for TED-related diplopia. An appropriate selection of cases along with a pretreatment magnetic resonance imaging to look for radiologically active disease aids in better planning and understanding of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_175_25","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:00:30Z","timestamp":1772218830000},"page":"75-80","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Role of concurrent intravenous pulse steroids and orbital radiation in the management of thyroid eye disease"],"prefix":"10.4103","volume":"19","author":[{"given":"Nisar Sonam","family":"Poonam","sequence":"first","affiliation":[{"name":"Department of Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Shahid","family":"Alam","sequence":"additional","affiliation":[{"name":"Department of Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Aditya Birla Sankara Nethralaya, Kolkata, (A Unit of Medical Research Foundation, Chennai), India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atanu","family":"Barh","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplasty, ASG Eye Hospital, Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Balasundaram","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Rela Hospital, Chennai, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bipasha","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Orbit, Oculoplasty, Reconstructive and Aesthetic Services, Sankara Nethralaya, Medical Research Foundation, Chennai, Tamil Nadu, 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