{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:01Z","timestamp":1787775661539,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Syphilis is a great mimicker of diseases and has a broad presentation ranging from painless chancre, constitutional symptoms, adenopathy, rash, synovitis, neurological, and ocular findings. Syphilis-related bone and joint involvement is usually found in congenital form, but it can also be seen in adults with acquired syphilis as a rare sequela of infectious syphilis. We report a case of a patient diagnosed as rheumatoid arthritis, who presented to the ophthalmology outpatient department with an acute onset of black spots in his visual field, whose clinical examination was a diagnostic dilemma, for which the patient underwent extensive investigations and was diagnosed to have syphilitic uveitis. In hindsight, it was concluded that the patient was suffering from reactive arthritis due to syphilis.<\/jats:p>","DOI":"10.4103\/ojo.ojo_183_25","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:00:34Z","timestamp":1772218834000},"page":"148-154","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["\u201cOcular syphilis with reactive arthritis mimicking rheumatoid arthritis\u201d \u2013 A diagnostic dilemma, case report, and review of literature"],"prefix":"10.4103","volume":"19","author":[{"given":"Asha Anne","family":"Jacob","sequence":"first","affiliation":[{"name":"Wellkins Medical Center, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Neil","sequence":"additional","affiliation":[{"name":"Wellkins Medical Center, Doha, Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"R1-20260302","first-page":"6594849","article-title":"Clinical features and treatments of syphilitic uveitis: A systematic review and meta-analysis","author":"Zhang","year":"2017","journal-title":"J Ophthalmol 2017"},{"key":"R2-20260302","first-page":"l4746","article-title":"Syphilis","volume":"366","author":"O'Byrne","year":"2019","journal-title":"BMJ"},{"key":"R3-20260302","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.rr7004a1","article-title":"Sexually transmitted infections treatment guidelines, 2021","volume":"70","author":"Workowski","year":"2021","journal-title":"MMWR Recomm Rep"},{"key":"R4-20260302","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s12879-021-06264-8","article-title":"Diagnostic tools for neurosyphilis: A systematic review","volume":"21","author":"Boog","year":"2021","journal-title":"BMC Infect Dis"},{"key":"R5-20260302","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1093\/cid\/cix604","article-title":"Increases in ocular syphilis-north carolina, 2014-2015","volume":"65","author":"Oliver","year":"2017","journal-title":"Clin Infect Dis"},{"key":"R6-20260302","doi-asserted-by":"crossref","first-page":"5394","DOI":"10.1167\/iovs.14-14559","article-title":"British ocular syphilis study (BOSS): 2-year national surveillance study of intraocular inflammation secondary to ocular syphilis","volume":"55","author":"Mathew","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R7-20260302","first-page":"987","article-title":"Ocular syphilis \u2013 A case series of four patients","volume":"19","author":"Jahnke","year":"2021","journal-title":"J Dtsch Dermatol Ges"},{"key":"R8-20260302","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/09273948.2017.1371765","article-title":"Ocular syphilis: An update","volume":"27","author":"Dutta Majumder","year":"2019","journal-title":"Ocul Immunol Inflamm"},{"key":"R9-20260302","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/jdv.16946","article-title":"2020 European guideline on the management of syphilis","volume":"35","author":"Janier","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R10-20260302","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0889-857X(21)00193-9","article-title":"Syphilitic arthritis and osteitis","volume":"19","author":"Reginato","year":"1993","journal-title":"Rheum Dis Clin North Am"},{"key":"R11-20260302","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1136\/bjo.2007.133843","article-title":"Syphilitic uveitis: An Asian perspective","volume":"92","author":"Anshu","year":"2008","journal-title":"Br J Ophthalmol"},{"key":"R12-20260302","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/ard.36.4.343","article-title":"The painful heel. Comparative study in rheumatoid arthritis, ankylosing spondylitis, Reiter's syndrome, and generalized osteoarthrosis","volume":"36","author":"Gerster","year":"1977","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"R13-20260302","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1136\/annrheumdis-2021-eular.1687","article-title":"Reactive arthritis in syphilis mimicking rheumatoid arthritis: A case report","volume":"80","author":"Lao","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"R14-20260302","doi-asserted-by":"crossref","first-page":"e937513","DOI":"10.12659\/AJCR.937513","article-title":"Case of secondary syphilis with mucocutaneous, articular, and pulmonary involvement in a 74-year-old moroccan man","volume":"23","author":"Mougui","year":"2022","journal-title":"Am J Case Rep"},{"key":"R15-20260302","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1097\/OLQ.0000000000001673","article-title":"Reported neurologic, ocular, and otic manifestations among syphilis cases-16 states, 2019","volume":"49","author":"Jackson","year":"2022","journal-title":"Sex Transm Dis"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_183_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:37:59Z","timestamp":1787773079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_183_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_183_25","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-05-12","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-24","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}