{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:22:09Z","timestamp":1787840529218,"version":"build-2784847793"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND:<\/jats:title>\n                    <jats:p>The aim of the study was to assess the midterm efficacy and safety of the iStent glaucoma device in patients with open-angle glaucoma (OAG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MATERIALS AND METHODS:<\/jats:title>\n                    <jats:p>We conducted a retrospective case series of all patients implanted with iStent inject\u00ae in OAG. Primary outcomes included intraocular pressure (IOP) and the reduction of antiglaucoma medications. Safety outcomes comprised adverse complications, additional surgeries, and postoperative best-corrected visual acuity (BCVA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Eight eyes from eight patients were included in this series. The mean age was 56.3 \u00b1 17.5 years. Six eyes had primary OAG and two eyes had secondary OAG. The majority of eyes (75%) had mild-to-moderate glaucoma. Five eyes underwent combined surgery, whereas the remaining three eyes underwent a standalone procedure. The mean baseline IOP was 22.9 \u00b1 8.2 mmHg, and the mean IOP at 2 years after the procedure was 13.6 \u00b1 2.8 mmHg. There was a 44.5% (10.2 \u00b1 2.5 mmHg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002) IOP reduction over 2 years. There was also a reduction in medication burden from a baseline mean of 3.4 \u00b1 0.7 to 2.0 \u00b1 1.2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.17). There was no documented intraoperative adverse complication, whereas one patient required trabeculectomy post iStent for IOP control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>iStent inject implantation safely reduced IOP and medication burden up to 24 months postoperative.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_223_23","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T05:02:02Z","timestamp":1740459722000},"page":"28-32","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["A 2-year longitudinal evaluation of the iStent inject\u00ae system for open-angle glaucoma in East Asian eyes"],"prefix":"10.4103","volume":"18","author":[{"given":"Ru Jian Jonathan","family":"Teoh","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupini","family":"Yogesvaran","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicia Foo Yuen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roslinah","family":"Muji","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"R1-20250225","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"R2-20250225","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: A systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"R3-20250225","doi-asserted-by":"crossref","first-page":"e0198799","DOI":"10.1371\/journal.pone.0198799","article-title":"Estimates of visual impairment and its causes from the National Eye Survey in Malaysia (NESII)","volume":"13","author":"Chew","year":"2018","journal-title":"PLoS One"},{"key":"R4-20250225","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7326\/0003-4819-158-4-201302190-00008","article-title":"Comparative effectiveness of treatments for open-angle glaucoma: A systematic review for the U. 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Cataract surgery with trabecular micro-bypass stent implantation in patients with mild-to-moderate open-angle glaucoma and cataract: Two-year follow-up","volume":"38","author":"Craven","year":"2012","journal-title":"J Cataract Refract Surg"},{"key":"R9-20250225","doi-asserted-by":"crossref","first-page":"6509809","DOI":"10.1155\/2016\/6509809","article-title":"Medical management of glaucoma in the 21st century from a Canadian perspective","volume":"2016","author":"Harasymowycz","year":"2016","journal-title":"J Ophthalmol"},{"key":"R10-20250225","doi-asserted-by":"crossref","first-page":"1056573","DOI":"10.1155\/2016\/1056573","article-title":"Glaukos iStent inject\u00aetrabecular micro-bypass implantation associated with cataract surgery in patients with coexisting cataract and open-angle glaucoma or ocular hypertension: A long-term study","volume":"2016","author":"Arriola-Villalobos","year":"2016","journal-title":"J 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series","volume":"2017","author":"Shiba","year":"2017","journal-title":"J Ophthalmol"},{"key":"R23-20250225","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/IJG.0000000000001805","article-title":"Standalone iStent trabecular micro-bypass glaucoma surgery: A systematic review and meta-analysis","volume":"30","author":"Healey","year":"2021","journal-title":"J Glaucoma"},{"key":"R24-20250225","doi-asserted-by":"crossref","first-page":"360","DOI":"10.4103\/2211-5056.364567","article-title":"Trabecular microbypass stent combined with phacoemulsification in patients with open-angle glaucoma, 1-year outcome in a Taiwanese population","volume":"13","author":"Su","year":"2023","journal-title":"Taiwan J Ophthalmol"},{"key":"R25-20250225","doi-asserted-by":"crossref","first-page":"67","DOI":"10.5005\/jp-journals-10028-1248","article-title":"Efficacy and adverse event profile of the iStent and iStent inject trabecular micro-bypass for open-angle glaucoma: A 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