{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:26:15Z","timestamp":1787772375022,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Thromboembolic complications are being increasingly reported in patients with COVID-19 due to the associated hypercoagulability and are an important cause for morbidity and mortality. Retinal vascular occlusions especially arterial occlusions are one of the gravest ocular complications reported. This complication may occur in severe cases with cytokine storm or even in mild or asymptomatic patients and presentation can be anytime from few days to weeks after the onset of symptoms. Ophthalmologists should be aware of this new etiology when dealing with patients having features of retinal vascular occlusions and should investigate for the same in this pandemic situation. Although reverse transcriptase polymerase chain reaction is the diagnostic test for COVID-19, serological assays have a role in patients with delayed presentation. We describe the clinical features and multimodal imaging findings in a patient who presented with features of central retinal artery occlusion with cilioretinal artery sparing wherein his ophthalmic condition led to the diagnosis of previously undetected COVID-19 through serology. To the best of our knowledge, this is the first documentation of a case of isolated central retinal artery occlusion leading to a retrospective diagnosis of COVID-19.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_226_21","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:51:33Z","timestamp":1716558693000},"page":"234-236","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Retrospective diagnosis of COVID-19 following the detection of central retinal artery occlusion"],"prefix":"10.4103","volume":"15","author":[{"given":"T.","family":"Lekha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosina","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anantharaman","family":"Giridhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh","family":"Gopalakrishnan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-25-20240908","doi-asserted-by":"crossref","first-page":"e00867","DOI":"10.1016\/j.idcr.2020.e00867","article-title":"Unique case of central retinal artery occlusion secondary to COVID-19 disease","volume":"21","author":"Acharya","year":"2020","journal-title":"IDCases"},{"key":"R2-25-20240908","doi-asserted-by":"crossref","first-page":"28","DOI":"10.21037\/aes.2018.05.04","article-title":"Acute retinal arterial ischemia","volume":"3","author":"Dattilo","year":"2018","journal-title":"Ann Eye Sci"},{"key":"R3-25-20240908","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/joim.13156","article-title":"COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?","volume":"289","author":"Landecho","year":"2021","journal-title":"J Intern Med"},{"key":"R4-25-20240908","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/ijo.IJO_297_21","article-title":"COVID-19 and eye: A review of ophthalmic manifestations of COVID-19","volume":"69","author":"Sen","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R5-25-20240908","doi-asserted-by":"crossref","first-page":"588384","DOI":"10.3389\/fphar.2020.588384","article-title":"Case report: Central retinal artery occlusion in a COVID-19 patient","volume":"11","author":"Montesel","year":"2020","journal-title":"Front Pharmacol"},{"key":"R6-25-20240908","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1080\/09273948.2021.1891262","article-title":"Simultaneous bilateral central retinal artery occlusion following COVID-19 infection","volume":"29","author":"Bapaye","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"R7-25-20240908","doi-asserted-by":"crossref","first-page":"620222","DOI":"10.3389\/fpubh.2020.620222","article-title":"Recent advances in the evaluation of serological assays for the diagnosis of SARS-CoV-2 infection and COVID-19","volume":"8","author":"Chiereghin","year":"2020","journal-title":"Front Public Health"},{"key":"R8-25-20240908","doi-asserted-by":"crossref","first-page":"106440","DOI":"10.1016\/j.clineuro.2020.106440","article-title":"Monocular visual loss as the presenting symptom of COVID-19 infection","volume":"201","author":"Murchison","year":"2021","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_226_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:41:19Z","timestamp":1787769679000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_226_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_226_21","relation":{},"ISSN":["0974-620X"],"issn-type":[{"value":"0974-620X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}