{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:25:49Z","timestamp":1787772349809,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"\n AIMS:<\/jats:title>\n The aim of this study is to evaluate the effect of iron-deficiency anemia (IDA) on peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT).<\/jats:p>\n <\/jats:sec>\n \n SETTINGS:<\/jats:title>\n The study was conducted at tertiary eye care center in Central India.<\/jats:p>\n <\/jats:sec>\n \n DESIGN:<\/jats:title>\n This study was a prospective, cross-sectional, case\u2013control, and observational study.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS:<\/jats:title>\n In the present study, 58 eyes of patients with IDA were compared with 58 eyes of healthy individuals. All individuals underwent a thorough hematological, clinical, and ophthalmic examination, followed by peripapillary RNFL analysis using SD-OCT.<\/jats:p>\n <\/jats:sec>\n \n RESULTS:<\/jats:title>\n \n A total of 116 eyes were included in the study. The average RNFL thickness (RNFLT) in the cases was 97.26 \u00b1 5.96, and 102.32 \u00b1 6.26 (\n P<\/jats:italic>\n = 0.005) in controls. There was a significant RNFL loss in the temporal (66.76 \u00b1 6.1,\n P<\/jats:italic>\n = 0.02), superior (119.66 \u00b1 10.47,\n P<\/jats:italic>\n = 0.01), nasal (73.59 \u00b1 9.52,\n P<\/jats:italic>\n = 0.003), and inferior (129.05 \u00b1 10.96,\n P<\/jats:italic>\n = 0.001) quadrants in the cases and controls. Serum hemoglobin, iron, ferritin, total iron-binding capacity, and transferrin saturation were lower in the cases (\n P<\/jats:italic>\n < 0.05). A positive correlation was observed between average RNFLT and hemoglobin (\n r<\/jats:italic>\n = 0.321), iron (\n r<\/jats:italic>\n = 0.122), ferritin (\n r<\/jats:italic>\n = 0.152), and transferrin (\n r<\/jats:italic>\n = 0.190) levels.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSIONS:<\/jats:title>\n In patients with IDA, RNFLT was decreased in all quadrants compared to normal healthy individuals. The inferior and nasal RNFL showed a significant decrease in thickness. The presence of myopia, glaucoma, and diabetic and hypertensive retinopathy can exert an additive effect in the thinning of RNFLs and cause significant visual loss; hence, the correction of anemia is essential. There is a pressing need to raise public and health professional awareness of these problems and their prevention, diagnosis, and management.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/ojo.ojo_252_22","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:56:24Z","timestamp":1716558984000},"page":"263-267","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Peripapillary nerve fiber layer in patients with iron deficiency anemia: A cross-sectional study in a tertiary eye care center in Central India"],"prefix":"10.4103","volume":"16","author":[{"given":"Rajesh Subhash","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Government Medical College, Nagpur, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh Namdeo","family":"Ingle","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, 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