{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:22:24Z","timestamp":1787775744330,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Rho-associated protein kinase inhibitor (ROCK) therapy for corneal endothelial dysfunction or damage other than glaucoma has been reported with few ocular side effects. We report reticular epithelial edema (REE) with netarsudil (0.02%) therapy in four cases with different clinical scenarios (three cases with corneal transplant and one case postcataract extraction). REE developed in all cases variably and cleared on cessation of netarsudil in three cases. One case was continued on netarsudil due to REE sparing the visual axis with no active ocular complaints. Partial clearance of stromal edema observed in all cases was correlated clinically to visual acuity considering existing comorbidities in an individual case.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_2_22","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:50:51Z","timestamp":1676947851000},"page":"94-97","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Reticular corneal epithelial edema with topical netarsudil"],"prefix":"10.4103","volume":"16","author":[{"given":"Dipali P.","family":"Parmar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradnya K.","family":"Bhole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawan V.","family":"Garde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20240908","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1097\/ICO.0000000000000240","article-title":"New therapeutic modality for corneal endothelial disease using Rho-associated kinase inhibitor eye drops","volume":"33","author":"Koizumi","year":"2014","journal-title":"Cornea"},{"key":"R2-19-20240908","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13256-021-02665-0","article-title":"Rhopressa-induced corneal edema: A case report","volume":"15","author":"Chu","year":"2021","journal-title":"J Med Case Rep"},{"key":"R3-19-20240908","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/IJG.0000000000001516","article-title":"Reticular corneal edema or corneal honeycombing in eyes treated with netarsudil: A case series","volume":"29","author":"Moumneh","year":"2020","journal-title":"J Glaucoma"},{"key":"R4-19-20240908","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/ICO.0000000000002694","article-title":"Honeycomb epithelial edema associated with rho kinase inhibition: A case series and review of the literature","volume":"41","author":"Lyons","year":"2022","journal-title":"Cornea"},{"key":"R5-19-20240908","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s40265-018-0877-7","article-title":"Netarsudil ophthalmic solution 0.02%: First global approval","volume":"78","author":"Hoy","year":"2018","journal-title":"Drugs"},{"key":"R6-19-20240908","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/IJG.0000000000001636","article-title":"Reticular epithelial edema: An uncommon side effect of ROCK\/NET inhibitor netarsudil","volume":"29","author":"Chen","year":"2020","journal-title":"J Glaucoma"},{"key":"R7-19-20240908","doi-asserted-by":"crossref","first-page":"101087","DOI":"10.1016\/j.ajoc.2021.101087","article-title":"Case report: The use of netarsudil to improve corneal edema after laser peripheral iridotomy and descemet's membrane endothelial keratoplasty","volume":"22","author":"Chen","year":"2021","journal-title":"Am J Ophthalmol Case Rep"},{"key":"R8-19-20240908","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ajo.2020.04.002","article-title":"Reticular bullous epithelial edema in corneas treated with netarsudil: A case series","volume":"217","author":"Wisely","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"R9-19-20240908","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/ICO.0000000000002421","article-title":"Case series: Novel utilization of Rho-Kinase inhibitor for the treatment of corneal edema","volume":"40","author":"Davies","year":"2021","journal-title":"Cornea"},{"key":"R10-19-20240908","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1097\/ICO.0000000000002621","article-title":"Transient reticular cystic corneal epithelial edema with topical netarsudil: A case series and review","volume":"40","author":"LoBue","year":"2021","journal-title":"Cornea"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_2_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:41:15Z","timestamp":1787773275000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_2_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_2_22","relation":{},"ISSN":["0974-620X"],"issn-type":[{"value":"0974-620X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}