{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:28:42Z","timestamp":1787761722705,"version":"build-2784847793"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Multiple adverse effects have been reported in people receiving the COVID-19 vaccinations including few reports of optic neuritis. However, there is no report till date, of bilateral optic neuritis post-ChAdOx1-S (recombinant) vaccination. We report here, for the first time, such a case in a previously healthy woman. Although a direct causal relationship cannot be proven, there was a temporal association between the vaccination and the onset of optic neuritis. Some vaccine adjuvants inciting disproportionate systemic inflammation, molecular mimicry, and the hypercoagulable state seen after COVID-19 vaccination could be the possible causes for the development of optic neuritis. Clinicians should be aware of this adverse effect apart from various other adverse effects of COVID-19 vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/ojo.ojo_31_22","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T02:50:51Z","timestamp":1676947851000},"page":"157-160","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["A rare case of bilateral optic neuritis post-Covishield (ChAdOx1-S [recombinant]) vaccination"],"prefix":"10.4103","volume":"16","author":[{"given":"Tanie","family":"Natung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thangjam Amit","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oinam Somapika","family":"Devi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishita","family":"Pandey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-37-20240908","doi-asserted-by":"crossref","first-page":"488","DOI":"10.4103\/ijo.IJO_297_21","article-title":"COVID-19 and eye: A review of ophthalmic manifestations of COVID-19","volume":"69","author":"Sen","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R2-37-20240908","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/vaccines9040393","article-title":"Analysis of thrombotic adverse reactions of COVID-19 astrazeneca vaccine reported to eudravigilance database","volume":"9","author":"Tobaiqy","year":"2021","journal-title":"Vaccines (Basel"},{"key":"R3-37-20240908","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.4103\/ijo.IJO_2122_21","article-title":"Ophthalmic complications of COVID-19 vaccination","volume":"69","author":"Pawar","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"R4-37-20240908","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1007\/s00415-021-10780-7","article-title":"COVID-19 mRNA vaccination leading to CNS inflammation: A case series","volume":"269","author":"Khayat-Khoei","year":"2022","journal-title":"J Neurol"},{"key":"R5-37-20240908","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1080\/09273948.2021.1961815","article-title":"Acute thyroiditis and bilateral optic neuritis following SARS-CoV-2 vaccination with CoronaVac: A case report","volume":"29","author":"Leber","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"R6-37-20240908","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/cen3.12682","article-title":"Optic neuritis after COVID-19 vaccine application","volume":"13","author":"Garc\u00eda-Estrada","year":"2022","journal-title":"Clin Exp Neuroimmunol"},{"key":"R8-37-20240908","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/s13256-018-1903-9","article-title":"Optic neuritis following diphtheria, tetanus, pertussis, and inactivated poliovirus combined vaccination: A case report","volume":"12","author":"O'Brien","year":"2018","journal-title":"J Med Case Rep"},{"key":"R9-37-20240908","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 Inflammasome: An overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int J Mol Sci"},{"key":"R10-37-20240908","doi-asserted-by":"crossref","first-page":"108426","DOI":"10.1016\/j.clim.2020.108426","article-title":"On the molecular determinants of the SARS-CoV-2 attack","volume":"215","author":"Kanduc","year":"2020","journal-title":"Clin Immunol"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_31_22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:05:19Z","timestamp":1787760319000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_31_22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_31_22","relation":{},"ISSN":["0974-620X"],"issn-type":[{"value":"0974-620X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]}}}