{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:27:38Z","timestamp":1787772458119,"version":"build-2784847793"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:p>Chronic myeloid leukemia (CML) rarely presents under 15 years of age, and its incidence is as low as 2% of all leukemia. Ophthalmic manifestations often present either initially with the diagnosis or as a sign of relapse after remission. The recommended treatment is systemic chemotherapy, intrathecal chemotherapy, ocular irradiation, and\/or intravitreal methotrexate. Herein, we report a 13-year-old child with a history of CML and central nervous system relapse under remission currently. He presented to us with bilateral ophthalmic relapse. He was treated with ocular irradiation and intrathecal chemotherapy. On follow-up, the ophthalmic infiltration showed resolution, which was also seen on multimodal imaging.<\/jats:p>","DOI":"10.4103\/ojo.ojo_343_21","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T13:56:24Z","timestamp":1716558984000},"page":"359-362","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["A rare presentation of bilateral ophthalmic relapse of pediatric chronic myeloid leukemia: Multimodal imaging and treatment"],"prefix":"10.4103","volume":"16","author":[{"given":"Gaurav","family":"Garg","sequence":"first","affiliation":[{"name":"Department of Oculoplasty, Oncology and Aesthetics, View Care, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narendra","family":"Patidar","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyendra","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Orbit and Oculoplasty, Sadguru Netra Chikitsalaya, Chitrakoot, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,6,27]]},"reference":[{"key":"R1-20240908","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1182\/blood-2015-06-648667","article-title":"Pediatric chronic myeloid leukemia is a unique disease that requires a different approach","volume":"127","author":"Hijiya","year":"2016","journal-title":"Blood"},{"key":"R2-20240908","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1038\/s41598-020-58654-8","article-title":"Ocular manifestations of leukemia and results of treatment with intravitreal methotrexate","volume":"10","author":"Vishnevskia-Dai","year":"2020","journal-title":"Sci Rep"},{"key":"R3-20240908","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4103\/JDRNTRUHS.JDRNTRUHS_6_18","article-title":"Atypical presentation of chronic myeloid leukemia with visual disturbance","volume":"7","author":"Chennamaneni","year":"2018","journal-title":"J Dr NTR Univ Health Sci"},{"key":"R4-20240908","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1159\/000504928","article-title":"Ophthalmologic manifestations as initial presentation of patients with chronic myeloid leukemia:Report of two cases","volume":"13","author":"Mohamed","year":"2020","journal-title":"Case Rep Oncol"},{"key":"R5-20240908","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1002\/cncr.25717","article-title":"Practical advice for determining the role of BCR-ABL mutations in guiding tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia","volume":"117","author":"Jabbour","year":"2011","journal-title":"Cancer"},{"key":"R6-20240908","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0929-6646(10)60123-4","article-title":"Recent research advances in childhood acute lymphoblastic leukemia","volume":"109","author":"Pui","year":"2010","journal-title":"J Formos Med Assoc"},{"key":"R8-20240908","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/sj.eye.6701308","article-title":"Ophthalmic manifestations of acute leukaemias:The ophthalmologist's role","volume":"18","author":"Sharma","year":"2004","journal-title":"Eye (Lond)"}],"container-title":["Oman Journal of Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_343_21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T18:47:59Z","timestamp":1787770079000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/ojo.ojo_343_21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.4103\/ojo.ojo_343_21","relation":{},"ISSN":["0974-620X","0974-7842"],"issn-type":[{"value":"0974-620X","type":"print"},{"value":"0974-7842","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"2021-11-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}